| 爬梯运动对Sarcopenia小鼠骨骼肌氧化应激状态的影响 |
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| 引用本文： | 李海鹏,卢健.爬梯运动对Sarcopenia小鼠骨骼肌氧化应激状态的影响[J].山西师大体育学院学报,2011,26(6):108-110. |
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| 作者姓名： | 李海鹏 卢健 |
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| 作者单位： | 1. 台州学院体育科学学院,浙江临海,317000
2. 华东师范大学体育与健康学院,上海,200241 |
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| 基金项目： | 教育部博士点基金项目，台州学院青年基金(博士专项)项目 |
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| 摘 要： | 目的：探讨爬梯运动对Sarcopenia小鼠骨骼肌抗氧化能力的影响。方法：以快速老化SAMP8小鼠为衰老动物模型,将其分为青年对照组（YC）、老年对照组（OC）和老年爬梯运动组（OR）,并对OR组小鼠进行八周运动干预,同时对各组腓肠肌T-AOC、SOD、CAT和MDA等指标进行检测。结果：（1）老年组SAMP8小鼠腓肠肌表现出Sarcopenia;（2）随增龄,OC组T-AOC、SOD和CAT均有所下降且具有显著性差异（P〈0.05）,MDA呈显著上调（P〈0.05）;（3）八周爬梯运动后,OR组T-AOC、SOD、CAT和MDA较OC组均有所上升,且差异具有显著性（P〈0.05）。结论：Sarcopenia的发生在一定程度上与骨骼肌中氧化应激水平密切相关,爬梯运动虽然能够提高Sarcopenia小鼠骨骼肌的抗氧化能力,但仍不足以充分缓解衰老骨骼肌中氧化损伤的发生。
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| 关 键 词： | 爬梯运动 肌肉衰减综合征 骨骼肌 氧化应激 |
Effects of Ladder Climbing Exercise on Oxidative Stress State in Sarcopenia Mice |
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| LI Hai-peng,LU Jian.Effects of Ladder Climbing Exercise on Oxidative Stress State in Sarcopenia Mice[J].Journal of Physical Education Institute of Shanxi Teachers University,2011,26(6):108-110. |
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| Authors: | LI Hai-peng LU Jian |
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| Institution: | 1. College of Physical Education, Taizhou University, Linhai, Zhejiang 317000, China; 2. College of P E ＆ Health, East China Normal University, Shanghai, 200241, China) |
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| Abstract: | Purpose： To discuss the effect of ladder climbing exercise on anti-oxidative capacity in Sarcopenia mice. Methods ： SAMP8 mice were selected as the aging model animal, with the grouping of young control group （YC）, old control group （OC） and old resistant exercise group （OR）. Eight weeks of ladder climbing exercise was used to intervene mice in OR group. T-AOC, SOD, CAT and MDA in Gastrocnemius were detected. Re- suits： （1）Sarcopenia have been shown in the Gastrocnemius of OC group; （2）The levels of T-AOC, SOD and CAT decreased significantly （ P 〈 0.05 ） with aging in OC group, while the level of MDA increased significantly （ P 〈 0.05 ） ; （ 3 ） The levels of T-AOC, SOD, CAT and MDA increased significantly （ P 〈 0.05 ） in OR group after eight weeks exercise. Conclusion： The level of ROS may involved in the process of Sarcopenia, and ladder climbing exercise could improve the anti-oxidant capacity of Gastrocnemius in Sarcopenia mice, but it was still not fully efficient to alleviate the oxidative damage in aging muscles. |
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| Keywords: | ladder climbing sarcopenia skeletal muscle oxidative stress |
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