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| 从HEPC 基因筛选预测HiHiLo 训练对左心室结构与功能影响的 分子标记 | |
| 引用本文： | 乌云格日勒,胡扬,衣龙彦,聂晶,王景玲,吉洪书.从HEPC 基因筛选预测HiHiLo 训练对左心室结构与功能影响的 分子标记[J].天津体育学院学报,2010,25(4):282-286. |
| 作者姓名： | 乌云格日勒 胡扬 衣龙彦 聂晶 王景玲 吉洪书 |
| 作者单位： | 1. 内蒙古师范大学,体育学院,呼和浩特,010022;北京体育大学,科学研究中心,北京,100084 2. 北京体育大学,科学研究中心,北京,100084 3. 江西师范大学,南昌,330027 4. 青岛体育训练基地,青岛,266023 5. 南京体育学院,南京,210014 |
| 摘 要： | 通过对HEPC基因SNP/A2032G 与HiHiLo 训练后左心室结构与功能指标变化的关联分析，从HEPC 基因中筛选预测HiHiLo 训练效果的分子标
记。方法：对66 名平原地区居住的北方汉族男子进行为期30 天的HiHiLo 训练，测定其训练前后安静状态和递增负荷运动下的左心室结构与功能指
标。应用PCR- RFLP 技术解析受试者SNP/A2032G 多态性，采用关联方法分析SNP/A2032G 与训练前后左心室结构功能指标变化的关联性。结果：（1）HiHiLo 训练后，受试者ESD、EDD、PWD、IVSD、LVM和LVMI 等6 项心室结构指标均增长；心室功能指标中HR、CO、COI 下降，而SV、SVI 和EF 增长。（2）HiHiLo 训练后，AA型PWD和IVSD的增加量显著高于AG型和GG型，AA型100W/HR 的下降量显著高于GG型，AA型Re/SV 和Re/SVI 的增加量显著高于AG型和GG型。结论：HEPC基因SNP/A2032G 的AA型可以作为预测HiHiLo 训练后心室结构和功能指标训练效果的分子标记。 |
| 关 键 词： | HEPC基因多态性 HiHiLo训练 左心室结构 左心室功能 |
Genetic Marker for Predicting the Effect of HiHiLo Training on Left Ventricular Structure and Function from HEPC Gene Selection |
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| WUYUN Gerile,HU Yang,YI Longyan,NIE Jing,WANG Jingling,JI Hongshu.Genetic Marker for Predicting the Effect of HiHiLo Training on Left Ventricular Structure and Function from HEPC Gene Selection[J].Journal of Tianjin Institute of Physical Education,2010,25(4):282-286. | |
| Authors: | WUYUN Gerile HU Yang YI Longyan NIE Jing WANG Jingling JI Hongshu |
| Institution: | 1.School of PE, Inner Mongolia Normal University, Hhhot 010022, China; 2.Graduate Schools, Beijing Sports University, Beijing 100084,China;Graduate Schools, Beijing Sports University, Beijing 100084, China;Graduate Schools, Beijing Sports University, Beijing 100084, China;School of PE, Jiangxi Normal University, Nanchang 330027, China;Qingdao Sport Training Center, Qingdao 266023, China;Nanjing Institute of Physical Education, Nanjing 210014, China |
| Abstract: | Objective: The association between SNP/A2032G in HEPC gene and the change of left ventricular structure and function after HiHiLo was analyzed and to provide as a genetic marker that can predict the efficiency of HiHiLo training. Methods: 66 male college-students from North of China were completed HiHiLo training for 30days and left ventricular structure/functional parameters in static and incremental exercise status for pre-post training was measured respectively. The SNP was ifferentiated by PCR-RFLP, then association between the change of left ventricular structure /function parameters and SNP/A2032G was analyzed by association studies with training response phenotypes. Results: (1) The ESD, EDD, PWD, IVSD, LVM and LVMI of subject were increased, and HR, CO and COI were decreased, but SV, SVI and EF were increased. (2) The increase of PWD and IVSD with AA were significantly higher than that AG and GG genotype, and an amount of decrease of 100W/HR with AA genotype was severity than GG genotype. Moreover, the increase of Re/SV and Re/SVI with AA genotype was significantly higher than AG and GG genotype. Conclusion: AA genotype of SNP/A2032G was maybe used as a genetic marker that can predict the efficiency with left ventricular structure/function after HiHiLo training. |
| Keywords: | HEPC gene polymorphism HIHILo training left ventricular structure left ventricular function |
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