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| 高频正弦波振动对制动大鼠比目鱼肌MHC表达的影响 | |
| 引用本文： | 石磊,曹若男,樊小力,陈龙伟.高频正弦波振动对制动大鼠比目鱼肌MHC表达的影响[J].西安体育学院学报,2012,29(3):345-349. |
| 作者姓名： | 石磊 曹若男 樊小力 陈龙伟 |
| 作者单位： | 1. 西安交通大学体育部,西安,710049 2. 西北大学外国语学院,西安,710069 3. 西安交通大学医学院生理学教研室,西安,710061 |
| 基金项目： | 国家自然科学基金资助项目(30901583);陕西省科学技术研究发展计划项目(2009KW-20);中央高校基本科研业务费专项资金资助项目(xjj20100181) |
| 摘 要： | 目的探讨高频正弦波振动(HFV)对制动大鼠比目鱼肌(SOL)梭内、外肌纤维肌球蛋白重链(MHC)表达的影响。方法采用大鼠后肢制动作为废用性肌萎缩动物模型,对振动组大鼠施以HFV,用免疫组化染色法检测大鼠SOL梭内、外肌纤维MHC表达。结果①制动14 d后,大鼠SOL梭外肌Ⅰ型肌纤维的构成比明显减少,Ⅱ型肌纤维的构成比明显增加(P<0.05),SOL梭内肌纤维快缩型MHC的表达有所增强;②制动加HFV大鼠与制动组相比,SOL梭外肌Ⅰ型肌纤维的构成比明显上升,Ⅱ型肌纤维的构成比明显下降(P<0.05),SOL梭内肌纤维快缩型MHC的表达没有明显变化。结论 HFV对制动大鼠SOL梭外肌Ⅰ型肌纤维向Ⅱ型肌纤维的转化和梭内肌MHC表达增强的趋势有明显的对抗作用。 |
| 关 键 词： | 高频正弦波振动 制动 肌球蛋白重链 肌梭 表达 |
Effects of High Frequency Sinusoidal Vibration Given to Soleus Muscle on Expression of MHC in Rats Under Immobilization |
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| SHI Lei , CAO Ruo-nan , FAN Xiao-li , CHEN Long-wei.Effects of High Frequency Sinusoidal Vibration Given to Soleus Muscle on Expression of MHC in Rats Under Immobilization[J].Journal of Xi'an Institute of Physical Education,2012,29(3):345-349. | |
| Authors: | SHI Lei CAO Ruo-nan FAN Xiao-li CHEN Long-wei |
| Institution: | 1a(1.Xi′an Jiaotong University,a.Department of Physical Education,Xi′an 710049,China; b.Department of Physiology of Medical School,Xi′an 710061,China; 2.College of Foreign Languages,Northwest University,Xi′an 710069,China) |
| Abstract: | Objective To study the effects of high frequency sinusoidal vibration given to soleus muscle on expression of MHC in rats under immobilization.Methods: The rats were made into models of disused muscles through the immobilization in their hindlimbs.HFV were applied to the immobilized soleus muscles in the vibration group.Using immunohistochemistry technique,changes of expression of MHC in intrafusal and extrafusal fibers in soleus muscle were detected.Results ①After the 14-day hindlimb immobilization period,the soleus muscles fibers showed an evident shift toward a decreased percentage of fibers typeⅠ,but an increased percentage of typeⅡ(P < 0.05).The expression of MHC in muscle spindle was increased.②Compared with the immobilization group,the soleus muscles fibers in the vibration group showed an evident shift toward a increased percentage of fibers typeⅠ,but an decreased percentage of typeⅡ(P < 0.05).The change of expression of MHC in muscle spindle was unconspicuous.Conclusion HFV is effective in antagonizing the transform of typeⅠtoward typeⅡ and the increased expression of MHC in muscle spindle in immobilization rats. |
| Keywords: | high frequency sinusoidal vibration immobilization myosin heavy chain muscle spindle expression |
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