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| 爬梯、跑台运动对小鼠骨骼肌中细胞凋亡调控基因的影响 | |
| 引用本文： | 李海鹏,杨东升,王立丰,丁树哲,卢健.爬梯、跑台运动对小鼠骨骼肌中细胞凋亡调控基因的影响[J].西安体育学院学报,2011,28(2):197-201. |
| 作者姓名： | 李海鹏 杨东升 王立丰 丁树哲 卢健 |
| 作者单位： | 1. 台州学院,体育科学学院,浙江,临海,317000;上海体育学院,运动科学学院,上海,200438 2. 浙江工业大学,体质健康研究中心,杭州,310014 3. 华东师范大学,体育与健康学院,上海,200241 |
| 基金项目： | 教育部博士点基金项目，台州学院青年基金(博士专项)项目 |
| 摘 要： | 目的观察爬梯与跑台两种不同运动方式对小鼠骨骼肌中细胞凋亡调控基因的影响。方法将实验小鼠分为安静对照组(YC)、爬梯运动组(YR)和跑台运动组(YE),采用实时荧光定量PCR的方法,分别对各组腓肠肌中凋亡调控基因(ARC、Bc l-2、Bax、HSP70、X IAP)及Caspase-3基因进行检测。结果 (1)与YC组相比,YR组ARC和HSP70 mRNA水平均显著上调(P<0.05),而Bax和Caspase-3 mRNA水平显著下调(P<0.05);(2)与YC组相比,YE组Bc l-2、HSP70和X IAP mRNA水平均显著上调(P<0.05),而ARC和Bax mRNA水平均显著下调(P<0.05)。结论爬梯和跑台运动均可干预凋亡调控基因而弱化骨骼肌细胞凋亡的潜能。 |
| 关 键 词： | 爬梯运动 跑台运动 小鼠 骨骼肌 细胞凋亡调控基因 |
Effects of Ladder- Climbing and Treadmill- Running Exercise Training on Apoptotic Regulating Genes in Skeletal Muscle |
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| LI Hai-peng,YANG Dong-sheng,WANG Li-feng,DING Shu-zhe,LU Jian.Effects of Ladder- Climbing and Treadmill- Running Exercise Training on Apoptotic Regulating Genes in Skeletal Muscle[J].Journal of Xi'an Institute of Physical Education,2011,28(2):197-201. | |
| Authors: | LI Hai-peng YANG Dong-sheng WANG Li-feng DING Shu-zhe LU Jian |
| Institution: | 1.Physical Education College,Taizhou University,Linhai 317000,China;2.Shanghai University of sport,shanghai 200438,China;3.Physical Education Science Research Institute,Zhejiang University of Technology,Hangzhou 310014,China;4.College of Physical Education & Health,East China Normal University,Shanghai 200241,China) |
| Abstract: | Objective To observe the effects of ladder climbing and treadmill running exercise training on apoptotic regulating genes in skeletal muscle.Methods The animals were divided into control group(YC),ladder climbing group(YR) and treadmill running group(YE).The method of Real-time PCR was used to detect the levels of apoptotic regulating genes,such as ARC,Bcl-2,Bax,HSP70,XIAP,and Caspase-3 in each group.Results(1) Compared to YC group,the levels of ARC,HSP70 mRNA increase significantly in YR group,on the contrary,the levels of Bax and Caspase-3 mRNA decreases significantly;(2) Compared to YC group,the levels of Bcl-2,HSP70 and XIAP mRNA increase significantly in YE group,while the levels of ARC and Bax mRNA decreases significantly.Conclusion Ladder climbing and treadmill running exercise training could attenuate the inclination of the apoptosis by affecting the apoptotic regulating genes separately in skeletal muscle. |
| Keywords: | ladder climbing exercise treadmill running exercise mice skeletal muscle apoptotic regulating genes |
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