Exercise training and impaired glucose tolerance in obese humans |
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| Authors: | Andrea Margaret McNeilly Marie Murphy Jane McEneny Tom Trinick George Burke |
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| Institution: | 1. Sport and Exercise Sciences Research Institute , University of Ulster , Co. Antrim , United Kingdom;2. Nutrition and Metabolism Group , Queens University Belfast , Belfast , United Kingdom;3. South Eastern Health and Social Care Trust , Ulster Hospital , Belfast , United Kingdom;4. Nanotechnology and Advanced Materials Research Institute , University of Ulster , Co. Antrim , United Kingdom |
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| Abstract: | Abstract Individuals with impaired glucose tolerance (IGT) are at greater risk of developing diabetes than in normoglycaemia. The aim of this study was to examine the effects of 12-weeks exercise training in obese humans with IGT. Eleven participants (6 males and 5 females; 49±9 years; mean Body Mass Index (BMI) 32.4 kg · m?2), completed a 12-week brisk walking intervention (30 min per day, five days a week (d · wk?1), at 65% of age-predicted maximal heart rate (HRmax). Anthropometric measurements, dietary intake, pulse wave velocity (PWV, to determine arterial stiffness) and blood pressure (BP) were examined at baseline and post intervention. Fasting blood glucose, glycosylated haemoglobin, insulin, blood lipids, indices of oxidative stress and inflammation (lipid hydroperoxides; superoxide dismutase; multimeric adiponectin concentration and high-sensitivity C-reactive protein) were also determined. Post intervention, PWV (9.08±1.27 m · s?1 vs. 8.39±1.21 m · s?1), systolic BP (145.4±14.5 vs. 135.8±14.9 mmHg), triglycerides (1.52±0.53 mmol . L?1 vs. 1.31±0.54 mmol . L?1), lipid hydroperoxides (1.20±0.47 μM · L?1 vs. 0.79±0.32 μM · L?1) and anthropometric measures decreased significantly (P < 0.05). Moderate intensity exercise training improves upper limb vascular function in obese humans with IGT, possibly by improving triglyceride metabolism, which may subsequently reduce oxidative stress. These changes were independent of multimeric adiponectin modification and alterations in other blood biomarkers. |
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| Keywords: | exercise arterial stiffness cardiovascular risk obesity |
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