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BONAGE超声骨龄测试和X光拍摄两种骨龄检测方法的比较研究
引用本文:许浩,邵慧秋,王磊,金吉中,王建萍.BONAGE超声骨龄测试和X光拍摄两种骨龄检测方法的比较研究[J].体育与科学,2008,29(6).
作者姓名:许浩  邵慧秋  王磊  金吉中  王建萍
作者单位:1. 江苏省体育科学研究所,南京,210014
2. 南京市体育科学研究所,南京,210000
3. 徐州市体育科学研究所,徐州,221006
基金项目:江苏省体育局局管体育科研课题 
摘    要:通过判读手掌和手腕骨的X光成像图片来评价青少年骨龄是体育和医学界一直使用的传统方法,长期的实践应用已证明它是行之有效的。但为变革其固有的缺陷对新的评价方法的探索一直没有停止,其中以色列阳光公司研制的BoneAge超声骨龄检测仪利用定量超声原理来评价骨龄,已批量投入市场且已为国内部分省市的体育部门所采用。研究目的:对BoneAge超声检测方法和传统X光拍摄方法进行方法学比较分析,检验新方法的准确性和有效性,以维护骨龄检测的权威性和科学性。研究对象:5-17岁男女青少年322名。研究方法:(1)超声骨龄仪的可重复性试验(实验对象93名);(2)X光片判读结果与超声检测结果的比较。对223名男女青少年拍摄手掌(腕)骨进行X光拍摄后随即使用BonAge超声骨龄检测仪对同批对象进行手腕部超声扫描。将超声骨龄结果与两位专家对X光片盲式读片结果的平均值进行比较分析。研究结果:(1)对超声骨龄仪的可重复性实验结果表明,两次测试的骨龄均值无显著性差异且呈高度相关,提示该仪器总体稳定性良好;(2)对超声骨龄结果与X光骨龄均值比较的显示,无论是区分年龄段还是性别,两种评定结果之间均有较大的系统误差和随机误差,且这种误差随年龄段的增大而有所加大;对年龄段较高的人群,超声检测结果更易高估对象的骨发育程度;单因变量多因素方差分析表明,骨龄评价结果主要受到评定方法和年龄段因素的影响,而与性别因素关系不大;对超声骨龄和X光骨龄的相关程度和直线回归分析表明,尽管总体人群的两种评价结果存在高度相关,直线回归效果较好,但引入年龄段因素后,相关程度明显降低,回归效果较差,提示这两种方法之间不能相互替代。

关 键 词:超声骨龄检测  X光骨龄片  方法学比较  系统误差  随机误差

A Methodological Copmparison between Ultrasound and X-ray Evaluations of Bone Age
XU Hao,SHAO Huiqiu,WANG Lei,JIN JiZhong,WANG Jianping.A Methodological Copmparison between Ultrasound and X-ray Evaluations of Bone Age[J].Sports & Science,2008,29(6).
Authors:XU Hao  SHAO Huiqiu  WANG Lei  JIN JiZhong  WANG Jianping
Abstract:The most conventional method of skeletal age assessment in children and adolescents uses CHN standards to evaluate the left hand radiograph.But a newly developed ultrasound device(BonAge System,made by Sunlight Medical Ltd.,Israel) has been widely put in use of skeletal growth evaluation.Objective: to compare the accuracy of the ultrasound method with the standard radiographic method.Participants: 322 children and adolescents aged 5-17 years,127 girls,195 boys.Materials and methods: 1)An repeated ultrasound examination of 93 participants' distal radial and ulna epiphysis was made to evaluate the new device's repeatability and stability.2) 229 participants underwent radiography of the left hand,followed by ultrasound measurement of the same hand using BonAge system.This system evaluates the relationship between the velocity of sound passing thorough the distal radial and ulna epiphysis and growth.Two experienced experts,blinded to each other and to the chronological age and BonAge result,analyzed the radiograph and gave out their own judgment of bone age according to CHN standards.The correlation between BonAge result and averaged specialists' judgments was analyzed.Results: 1)There was high correlation and no significant difference between the average of two repeated BonAge results.The device was quite stable in use.2) There were great systematic error and random error between the average values of ultrasound and radiograph bone ages not only in gender groups but in age groups as well.The error was enlarged with age older.The univariate analysis for one dependent variable by multi-factors showed that bone age results were mainly influenced by such factors as evaluation methods and age,but were not significantly related to gender.The results by two methods were also not highly correlatted especially for those older participants,so we cannot built a good linear regression relationship between the evaluation outcomes of two methods.Conclusion: There were great methodological differences between the principles of the BonAge and radiograph.The two methods can not be replaced each other.
Keywords:ultrasound bone age evaluation  bone age radiography  systematic error  random error
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