| 有氧运动对大鼠心血管自主神经中枢Glu能神经和GABA能神经的影响 |
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| 引用本文： | 王松涛,曾云贵,王安利.有氧运动对大鼠心血管自主神经中枢Glu能神经和GABA能神经的影响[J].体育科学,2007,27(4):64-71. |
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| 作者姓名： | 王松涛 曾云贵 王安利 |
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| 作者单位： | 1. 贵州师范大学,贵州,贵阳,550001
2. 北京体育大学,北京,100084 |
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| 摘 要： | 为验证谷氨酸（Glu）能神经和卜氨基丁酸（GABA）能神经之间的相互作用可能是有氧运动改变自主神经平衡状态的中枢机制之一，以正常大鼠为实验对象，以8周中等强度的游泳运动为干预手段，观察比较两组大鼠Glu能神经和GABA能神经免疫阳性产物在心血管自主神经中枢各核团内的表达情况，以及脑脊液中氨基酸类神经递质的变化。研究结果提示，长期参加有氧运动可通过下列中枢途径改变自主神经的平衡状态：降低下丘脑室旁核内Glu能神经纤维密度，增加GABA能神经纤维密度，从而改变下丘脑室旁核交感兴奋性神经元的“兴奋一抑制”平衡，表现为抑制性作用加强；改变孤柬核和疑核内兴奋性神经元和抑制性神经元的比例，从而增强应激状态下自主神经对心血管反射的调节能力或加强安静状态下的迷走神经紧张性；通过增加CVLM向RVLM投射的GABA能神经纤维，从而加强对RVLM内交感节前神经元的抑制；通过脑脊液中的氨基酸类神经递质含量的变化，对触液神经元的功能产生影响，从而影响心血管自主神经的平衡状态。
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| 关 键 词： | 有氧运动 心血管 自主神经 谷氨酸 γ-氨基丁酸 鼠 动物实验 |
| 文章编号： | 1000-677X（2007）04-0064-08 |
| 修稿时间： | 2006-12-012007-03-10 |
Effect of Aerobic Exercise on Glutamatergic and Gabaergic Nerves of Cardiovascular Autonomic Nerve Center in Rats |
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| WANG Song-tao,ZENG Yun-gui,WANG An-li.Effect of Aerobic Exercise on Glutamatergic and Gabaergic Nerves of Cardiovascular Autonomic Nerve Center in Rats[J].China Sport Science,2007,27(4):64-71. |
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| Authors: | WANG Song-tao ZENG Yun-gui WANG An-li |
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| Institution: | 1. Guizhou Normal University, Gniyang 550001, China; 2. Beijing Sports University, Beijing 100084, China. |
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| Abstract: | In order to test the hypothesis on interaction between glutamatergic nerves and gabaergic nerves contribute to the changing balance state of autonomic nerve,ordinary SD rats were divided into training group and control group.The training group undertook 8-week swimming exercise and observed and compared expression of glutamatergic nerves and gabaergic nerves by immunohistochemical method and amino acids neurotransmitter in cerebrospinal fluid by automatic amino acid analyzer.The results showed that the long-term aerobic exercise can change the balance state of cardiovascular autonomic nerve system,decrease glutamatergic nerves and increase gabaergic nerves in paraventricular hypothalamic nucleus(PVN),which will enhance sympathetic inhibition.Change the proportion of excitatory neuron and inhibitory neuron in nucleus tractus solitarii(NTS)and nucleus ambiguus(NA),which may enhance regulative ability of cardiovascular autonomic nerve to stress state,or increase vagal tone in resting state,increase gabaergic nerves fiber in caudal ventrolateral medulla(CVLM)projected to rostral ventrolateral medulla(RVLM),which can enhance inhibition effect on sympathetic preganglionic neuron in RVLM.Change the content of amino acids neurotransmitter in cerebrospinal fluid to influence ambient autonomic neuron. |
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| Keywords: | aerobic exercise cardiovascular autonomic nerve Glu GABA rat animal experiment |
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