| 运动介导肠道微生物-肠-脑轴调控神经功能的机制 |
| |
| 引用本文： | 余锋,贾芳芳,徐帅,汪君民,张宪亮.运动介导肠道微生物-肠-脑轴调控神经功能的机制[J].上海体育学院学报,2021(1):66-77. |
| |
| 作者姓名： | 余锋 贾芳芳 徐帅 汪君民 张宪亮 |
| |
| 作者单位： | 淮阴师范学院体育学院;苏州大学体育学院;山东大学体育学院 |
| |
| 基金项目： | 教育部人文社会科学研究青年基金项目(19YJC890056)。 |
| |
| 摘 要： | 神经功能障碍是导致脑认知能力衰退和神经退行性疾病的重要原因,但其内在的诱导机制尚不清楚。随着学界对肠道微生物研究的深入,发现肠道微生物在许多机体疾病的发展中扮演重要角色,而神经功能障碍亦不例外。肠神经系统与中枢神经系统的信息通路使得肠道微生物与神经功能建立了肠-脑轴间的联络,肠道微生态的变化可通过肠-脑轴间的联络而影响神经功能。研究发现,规律的运动可通过影响肠道微生态进而改善神经功能,抑制神经系统疾病,但其内在调节机制亦不明确,这可能与运动介导肠道微生物多样性、肠道免疫、肠道内分泌、肠道代谢以及运动改善肠-脑间神经联系和神经发生等机制有关。
|
| 关 键 词： | 运动 肠道微生物 微生物-肠-脑轴 神经功能 |
Mechanism of Exercise Regulating Neurological Function by GutMicrobiota-Gut-BrainAxis |
| |
| YU Feng,JIA Fangfang,XU Shuai,WANG Junmin,ZHANG Xianliang.Mechanism of Exercise Regulating Neurological Function by GutMicrobiota-Gut-BrainAxis[J].Journal of Shanghai Physical Education Institute,2021(1):66-77. |
| |
| Authors: | YU Feng JIA Fangfang XU Shuai WANG Junmin ZHANG Xianliang |
| |
| Institution: | (School of Physical Education,Huaiyin Normal University,Huaian 223300,Jiangsu,China;School of Physical Education,Soochow University,Suzhou 215021,Jiangsu,China;School of Physical Education,Shandong University,Jinan 250061,Shandong,China) |
| |
| Abstract: | Neurological dysfunction is an important cause of cognitive decline and neurodegenerative diseases,but the underlying mechanism is still unclear.With the deepening of the research on intestinal microbiota,it is found that gut microbiota plays an important role in the development of many diseases,and neurological dysfunction is no exception.The information pathway between the enteric nervous system and the central nervous system enables the gut microbiota to establish a connection of gut-brain axis with neurological function.The changes of intestinal microecology can affect the neurological function through the connection of gut-brain axis.It has been found that regular exercise can improve neurological function and inhibit nervous system diseases by affecting intestinal microecology.However,its internal regulatory mechanism is not clear,which may be related to the mechanism of exercise mediated intestinal microbial diversity,intestinal immunity,intestinal endocrine,intestinal metabolism,and the improvement of gut-brain neural connection and neurogenesis. |
| |
| Keywords: | exercise gut microbiota microbiota-gut-brain axis neurological function |
| 本文献已被 维普 等数据库收录！ |
|
