Metabolic response to 6-week aerobic exercise training and dieting in previously sedentary overweight and obese pre-menopausal women: A randomized trial |
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| Institution: | 1. Department of Health Sciences, University of Jyväskylä, FI-40014 Jyväskylä, Finland;2. Department of Medical Rehabilitation, Oulu University Hospital, Oulu FI-90029, Finland;3. Institute of Health Sciences, University of Oulu, Oulu FI-90014, Finland;4. School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China;5. Department of Sport and Physical Education, Shanghai Jiao Tong University, Shanghai 200240, China |
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| Abstract: | BackgroundThe aim of this study was to compare 6 weeks short-term moderate intensity aerobic exercise and dieting on serum metabolomics and cardio-metabolic risk factors in pre-menopausal women.MethodsNinety previously inactive overweight and obese (BMI 25–35 kg/m2) women (age 41.5 ± 7.6 years) were randomized to either a 6-week Nordic walking exercise program (EX, n = 45) or dietary counseling group (DI, n = 45). Body composition, serum glucose, insulin and lipids were measured. Serum low-molecular-weight metabolites and lipid constituents were analyzed by nuclear magnetic resonance spectroscopy. Measurements were done at baseline and 7 days after the last training session.ResultsSix weeks aerobic exercise program yielded reductions in serum free fatty acids (?34.7%, 95% confidence interval (CI), ?50 to ?18, p < 0.001), glucose (?9.6%, 95%CI, ?15 to ?4, p < 0.001) and homeostasis model assessment of insulin resistance (HOMA-IR) (?28.7%, 95%CI, ?48 to ?10, p = 0.005) without changes in body weight or fat mass. Diet counseling resulted in loss of body weight (1.5%, 95%CI, ?2.3 to ?0.7, p = 0.001) but no changes in free fatty acids, fasting glucose, or HOMA-IR were found.ConclusionOur results indicate that small weight loss does not produce measurable health benefits, whereas short-term regular aerobic exercise can improve glucose and lipid metabolism even in the absence of weight loss in previously sedentary overweight and obese women. |
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| Keywords: | Dieting Exercise Metabolism Metabolomics Women |
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