| 梗阻性黄疸肝肾细胞内胆汁酸活度的变化 |
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| 引用本文： | 牟一平,刘俊涛.梗阻性黄疸肝肾细胞内胆汁酸活度的变化[J].科技通报,1996,12(6):321-323. |
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| 作者姓名： | 牟一平 刘俊涛 |
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| 作者单位： | [1]泊医科大学附属第二医院外科 [2]浙江大学生物医学工程研究所 |
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| 摘 要： | 本实验运用离子选择性微电极技术直接测定了鼠胆道梗阻前后肝、肾细胞内的胆汁酸活度。结果表明，胆道梗阻２周，肝、肾细胞内胆汁酸活度明显升高，其中肝细胞内达５．４６ｍｍｏｌ／Ｌ，肾细胞内达０．３７ｍｍｏｌ／Ｌ，已达到或接近体外膜损害浓度，提示胆汁酸可能是梗阻性黄疸引起肝、肾细胞超微结构损害的因素之一。
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| 关 键 词： | 胆汁酸 微电极 梗阻性黄疸 肾细胞 肝细胞 |
Intracellular Bile Acids Activity of Liver and Renal Cells in Obstructive Jaundice in Rats |
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| Mu Yiping, Peng Shuyou, Liu Juntao, et al.Intracellular Bile Acids Activity of Liver and Renal Cells in Obstructive Jaundice in Rats[J].Bulletin of Science and Technology,1996,12(6):321-323. |
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| Authors: | Mu Yiping Peng Shuyou Liu Juntao |
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| Abstract: | The aim of this study was to determine the intracellular bile acids activity in rats with or without bile duct ligation by ion-selective microelectrodes. The result showed that two weeks after the bile duct ligation,the intracellular bile acids activity in the liver and the renal cells increased obviously. They were 5. 46mmol/L and 0. 37 mmol/L, respectively. This result suggested that the increased intracellular bile acids may damage cytoplasmic organells, because they reach or near their membrane damage concentration in vitro. |
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| Keywords: | bile acids and salts ion-selective microelectrodes bile duct obstruction extrahepatic |
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