| Abstract: | Fluorescent dyes can be used as cell probes which bind, according to their chemical structure, to particular subcellular regions of lymphocytes. Because of their sensitivity to variations in the local molecular environment, expressed by changes in fluorescence emission, they provide a means of studying the early events of lymphocyte activation to antigens and mitogens. The technology also yields a rapid assay of lymphocyte activation and thus new diagnostic tests of cell-mediated immunity, for example to organ transplants and to cancer. |
