Detection of L1 CAM mutation in a male child with mental retardation |
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| Authors: | M Swarna M Sujatha P Usha Rani P P Reddy |
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| Institution: | (1) Institute of Genetics and Hospital for Genetic Diseases, Begumpet, 500 016 Hyderabad, A.P., India |
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| Abstract: | Recent studies have presented evidence for the involvement of L1CAM gene mutations in various X-linked mental retardation
syndromes. The neural cell adhesion molecule, L1CAM is a transmembrane protein belonging to the super family of the immunoglobulins
that play a key role in embryonic development of the nervous system and is involved in memory and learning. No studies were
carried out from India on L1 CAM gene in X-linked mental retardation syndromes. Hence, an investigation was taken up to delineate
the role of L1CAM gene in mental retardation.
Two families (Family I and Family II) having only two members affected with mental retardation in each family were studied
for mutations in L1CAM gene. In family II, the younger sibling showed deletion involving region between the nucleotide 13,773
(intron 25) and 14,158 (intron 27) region. The mutation what we observed in younger sibling of the family II is a novel mutation
which was not hitherto reported in the world literature. |
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| Keywords: | X-linked mental retardation syndromes CRASH L1 CAM mutation |
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