Serum glycoconjugates and ceruloplasmin in cancer of uterine cervix |
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| Authors: | Sharmila Upadhya Subramanya Upadhya K S Prabhu |
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| Institution: | (1) Department of Physiology, Kasturba Medical College, Manipal;(2) Department of Biochemistry, Kasturba Medical College, 576 119 Manipal |
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| Abstract: | The present study was done to assess the levels of glycoconjugates and ceruloplasmin in sera of patients with cervical cancer.
Serum hexoses, hexosamines, sialic acid and fucose are elevated in a variety of inflammatory and neoplastic conditions. All
the glycoconjugates, except fucose were increased in serum of patients compared to controls. Also, hexoses and sialic acid
levels were high in patients with later stages of cancer compared to patients with early stage disease (P=<0.0001, P=0.03).
Serum ceruloplasmin was increased in patients with early stage cancer (51.5mg/dl) and with late stage cancer (61mg/dl) compared
to controls (38mg/dl). The elevated glycoconjugates may be the result of inflammatory reaction associated with neoplasia,
as serum ceruloplasmin (an acute phase reactant) is also increased in these patients. |
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| Keywords: | Sialic acid fucose Ceruloplasmin cervical cancer |
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