Serum adenosine deaminase, 5′ nucleotidase and malondialdehyde in acute infective hepatitis |
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| Authors: | K Pratibha Usha Anand Rajni Agarwal |
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| Institution: | (1) Department of Biochemistry, M.S. Ramaiah Medical College, 560054 Bangalore, Karnataka, India |
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| Abstract: | Serum adenosine deaminase (ADA), 5′ nucleotidase (5′NT) and malondialdehyde (MDA) were estimated in patients with acute infective
hepatitis (AIH) along with the routine parameters of liver disease. Present study is done to evaluate these special parameters
in patients with clinical history of AIH and to assess the utility of these parameters as diagnostic/ prognostic indices of
liver function and to correlate special parameters with routine live function tests (LFT). ADA, 5′NT and MDA along with routine
LFT was estimated in 25 patients with AIH and 25 samples from healthy voluntary blood donars served as the control group.
Routine LFT was estimated by standard clinical chemistry procedures on dade behring analyser and ADA, 5′NT and MDA were estimated
by berthlot reaction, fiske and subbarao method and thiobarbituric acid method respectively.
Statistical analysis showed that serum ADA, 5′NT and MDA were significantly higher in patients as compared with the controls.
There was a significant positive correlation between ADA and total bilirubin and MDA and total bilirubin. Hence we can conclude
that these tests would be more sensitive to diagnose the patients with AIH and that the raised bilirubin levels could be looked
upon, as a protective mechanism which the liver has evolved in order to combat oxidative stress. |
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| Keywords: | ADA 5′ NT MDA AIH |
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