Effect of oral antioxidant supplementation on lipid peroxidation during radiotherapy in head and neck malignancies |
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| Authors: | Anissa Kaleemullah Shariff Sangita R Patil Pramod S Shukla Ajit V Sontakke Anup S Hendre Anand K Gudur |
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| Institution: | (1) Department of Surgery, College of Medicine, King Faisal University, Al-Ehssa 31982, P O Box 400, Al-Ahsa, Saudi Arabia;(2) ENT Department, Sohag Faculty of Medicine, Sohag University, Sohag, 82524, Egypt;(3) Zoology Department, Sohag Faculty of Science, Sohag University, Sohag, 82524, Egypt |
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| Abstract: | The objectives of the present study were to ascertain the variations in the serum levels of malondialdehyde and total antioxidant
status, in head and neck malignancies with different stages, with and without oral antioxidant supplementation, before and
after radiotherapy, and to validate the protective effects of an antioxidant supplementation during radiotherapy. The pretreatment
values of serum malondialdehyde were significantly raised, while that of serum total antioxidant status were significantly
declined in all the stages of head and neck malignancies, when compared with the healthy controls values (P<0.001). A significant
correlation was observed related to the studied parameters and different stages of the disease. The study suggests that an
oral antioxidant supplementation during radiotherapy is an effective mode in reducing oxidative stress. Antioxidant supplementation
during radiotherapy may serve as an adjuvant therapy in malignancies offering a protection to normal cells that may further
reduce the risk of developing secondary cancers. |
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