Relationship of Brain-Derived Neurotrophic Factor with Interleukin-23, Testosterone and Disease Severity in Schizophrenia |
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| Authors: | Priya Allimuthu Hanumanthappa Nandeesha Raghavi Chinniyappan Balaji Bhardwaz Jesudas Blessed raj |
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| Institution: | 1.Department of Biochemistry and Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India ;2.Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India |
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| Abstract: | Hormonal imbalance, inflammation and alteration in synaptic plasticity are reported to play a crucial role in the pathogenesis of schizophrenia. The objective of the study was to assess the serum levels of brain derived neurotrophic factor (BDNF) and its association with interleukin-23 (IL-23), testosterone and disease severity in schizophrenia. 40 cases and 40 controls were included in the study. Serum levels of BDNF, IL-23 and testosterone were estimated in all the subjects. Disease severity was assessed using Positive and Negative Syndrome Scale (PANSS). The study was designed in Tertiary care hospital, South India. The results were compared between two groups using Mann–Whitney U test. Spearman Correlation analysis was used to assess the association between biochemical parameters and PANSS. Interleukin-23 and testosterone were significantly increased and BDNF was significantly reduced in schizophrenia cases when compared with controls. BDNF was negatively correlated with IL-23 (r = − 400, p = 0.011), positive symptom subscale (r = − 0.393, p = 0.012), general psychopathology score subscale (r = − 407, p = 0.009) and total symptom subscale (r = − 404, p = 0.010). There was no significant association of IL-23 and testosterone with disease severity in schizophrenia cases. BDNF was reduced in schizophrenia cases and negatively associated with interleukin-23 and disease severity scores. |
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| Keywords: | Schizophrenia Brain derived neurotrophic factor Inflammation Testosterone Positive and Negative symptom score |
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