Thyroid hormones status during pregnancy in normal Iranian women |
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| Authors: | Nosratollah Zarghami Mohammad Rohbani-Noubar Ali Khosrowbeygi |
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| Institution: | (1) Department of Clinical Biochemistry and RIA, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
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| Abstract: | Pregnancy is associated with significant, but reversible changes in thyroid function studies, which are among the most profound
seen as a result of a normal physiologic state. The present study was carried out to find out alterations in thyroid function
tests in each trimester in normal pregnant women as compared to non-pregnant women in Tabriz-Iran. A case-control study designed
with 229 normal pregnant women that randomly selected from the first (64 samples), the second (92 samples), and the third
(73 samples) trimesters and 250 randomly selected non-pregnant healthy female controls. Age range in both groups was 16–40
years. Thyroid function tests carried out by measuring serum levels of thyroid stimulating hormone (TSH), free and total thyroxin
(FT4, TT4), and free and total triiodothyronine (FT3, TT3) by commercially available radio immunoassay kits. We found that mean TT4 increased progressively during pregnancy. Our study showed increasing in serum levels of TT3 in the second trimester and then declining during the third trimester compared with non-pregnant women. We showed that FT4 strongly decreased during the third trimester. Free T3 showed declining in the second and third trimesters. Mean TSH did not show significant difference in each trimester compared
with non-pregnant women. The thyroid function tests in pregnancy should be interpreted against gestational age-related reference
intervals to avoid mis-interpretation of thyroid function during pregnancy. |
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| Keywords: | FT3 FT4 Pregnancy TT3 TT4 TSH |
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