Adiponectin Gene Polymorphism and its Association with Type 2 Diabetes Mellitus |
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| Authors: | Devadrita Biswas V Vettriselvi Jnankumar Choudhury R Jothimalar |
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| Institution: | (1) Department of Biochemistry, Sri Ramachandra Medical College and Research Institute, Chennai, 600116, Tamilnadu, India;(2) Department of Human Genetics, Sri Ramachandra Medical College and Research Institute, Chennai, 600116, Tamilnadu, India;(3) Department of Biochemistry, ACS Medical College, Velappanchavadi, Chennai, 600077, Tamilnadu, India |
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| Abstract: | Mutations in different regions of adiponectin gene have been reported to be associated with obesity, atherosclerosis and type
2 diabetes mellitus. The present study was aimed to investigate the association among SNP 45 T > G of adiponectin gene and
type 2 diabetes in South Indian population. 75 clinically diagnosed case of type 2 diabetes were studied and compared with
75 apparently healthy controls. The genotype frequency of SNP45 T > G in exon 2 of adiponectin gene was determined by PCR
based restriction enzyme analysis using the restriction enzyme SmaI. (recognition site: CCC↓GGG). Three kind of genotypes: wild type TT (470 bp), heterozygous type TG (470 bp, 336 bp, 134 bp)
and homozygote mutant type GG (336 bp, 134 bp) were studied. A positive association has been found between SNP45 T > G and
type 2 diabetes in the study population (P = 0.010, OR = 3.797, 95% CI = 1.312–10.983). Therefore, SNP45T > G in adiponectin gene may be one of the risk factors for
type 2 diabetes. |
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| Keywords: | Adiponectin gene Type 2 diabetes Polymorphism |
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