Role of Common Biochemical Markers for the Assessment of Fracture Union |
| |
| Authors: | M Mukhopadhyay R Sinha M Pal S Bhattacharyya A Dan M M Roy |
| |
| Institution: | (1) Department of Biochemistry, Medical College, 88, College Street, Kolkata, 700072, West Bengal, India;(2) Department of Orthopedics, Medical College, Kolkata, India;(3) Department of Biochemistry, KPC Medical College, Kolkata, India;(4) Department of Biochemistry, R.G. Kar, Medical College, Kolkata, India;(5) Department of Community Medicine, NRSMC, Kolkata, India;(6) 27/14 Andul Road, PO Danseh SK Lane, Howrah, 711109, India |
| |
| Abstract: | The progress of fracture union requires close monitoring. Whereas, clinical examination and radiographic studies assess the
outcome, biochemical markers like serum alkaline phosphatase and urinary hydroxyproline reflect the actual status of bone
resorption and bone formation over a short time frame. 36 patients of long bone fracture were randomly allocated for the study.
When the patient reported to the Department of Orthopedics after fracture, serum and urinary samples were collected and X-ray
of the affected part were taken. Subsequent samples were collected and X-ray taken just after management (either operative
or conservative), after 3rd, 5th, 8th and 12th week, respectively after onset of fracture. According to the course of callus
formation the patients were divided into two groups that progressed to proper union or malunion. The levels of serum alkaline
phosphatase, urinary total and free hydroxyproline levels were measured and statistically analysed and compared. A statistically
significant positive correlation between total urinary hydroxyproline excretion and serum alkaline phosphatase indicate progress
towards satisfactory union. Thus, serial monitoring of biochemical markers of bone turnover can be used as an adjunct to clinical
and radiological evidence of fracture healing. |
| |
| Keywords: | Fracture union Biochemical markers Urinary total hydroxyproline Urinary free hydroxyproline Serum alkaline phosphatase |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
