Age-Dependent Changes in Glutathione-S-Transferase: Correlation with Total Plasma Antioxidant Potential and Red Cell Intracellular Glutathione |
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| Authors: | Pawan Kumar Maurya Syed Ibrahim Rizvi |
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| Institution: | (1) Amity Institute of Biotechnology, Amity University, Noida, 201303, India;(2) Department of Biochemistry, University of Allahabad, Allahabad, 211002, India; |
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| Abstract: | The correlation between antioxidant capacity and oxidative damage during aging has been reported in several tissues in different
species. Glutathione-S-transferases (GST) can metabolise endogenous and exogenous toxins and carcinogens by catalysing the
conjugation of diverse electrophiles with reduced glutathione (GSH). We observe a significant (P < 0.001) increase in plasma GST activity as a function of human age (r = 0.5675). A significant (P < 0.001) positive correlation (r = 0.8979) is observed between GST activity and total plasma antioxidant potential measured
as ferric reducing ability of the plasma (FRAP). GST activity and red cell intracellular GSH also show a significant positive
correlation (r = 0.7014). We hypothesize that the increased activity of plasma GST is a manifestation of increased generation
of ROS and a concomitant decrease in the level of plasma antioxidant capacity during aging. |
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| Keywords: | Glutathione-S-transferase Human aging Oxidative stress |
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