Hyperinsulinemia and Hypoadiponectinemia are Associated with Increased Risk for Occurrence of Ovarian Cancer in Non-diabetic Women of North Indian Population |
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| Authors: | Rohit Kumar Gupta Sagar Jayantilal Dholariya Smita Kaushik S K Gupta Reva Tripathi Shyam Lata Jain |
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| Institution: | 1.Department of Biochemistry, Lady Hardinge Medical College, New Delhi, India ;2.Department of Biochemistry, R. D. Gardi Medical College, Ujjain, M.P. India ;3.Department of Biochemistry, Maulana Azad Medical College, New Delhi, India ;4.Department of Obstetrics and Gynecology, Maulana Azad Medical College, New Delhi, India ;5.Department of Pathology, Maulana Azad Medical College, New Delhi, India |
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| Abstract: | Ovarian cancer has been emerged as a most common and lethal gynecological malignancy in India. High serum insulin and low adiponectin have been associated with increased risk of ovarian cancer. But their role in development of ovarian cancer is conflicting and little evidence is available. We aimed to evaluate blood levels of insulin and adiponectin in epithelial ovarian cancer (EOC) patients and their association with the risk to develop EOC. The study included following three groups; Group 1: fifty cases of cytohistopathologically confirmed cases of EOC, Group 2: fifty age matched cases of benign ovarian conditions and Group 3: fifty ages matched healthy controls with no evidence of any benign or malignant ovarian pathology as ruled out by clinical examination and relevant investigations. Cytohistopathologically confirmed and newly diagnosed cases of EOC and benign ovarian cancer were included in this study. The median value of fasting serum insulin was significantly high (15.0 µlU/ml, P = 0.02) and adiponectin were significantly low (5.1 µg/ml, P < 0.001) in ovarian cancer patients compared to benign ovarian tumors and healthy controls group. A significant increase risk of ovarian cancer was found in high tertile (≥ 18.7 µlU/ml) of serum insulin level (OR = 2.7; 95% CI = 1.00–6.67, P = 0.04) and lower tertile (≤ 5.45 µg/ml) of adiponectin level (OR = 3.2; 95% CI = 1.10–9.71, P = 0.03). High serum insulin level and low adiponectin levels were significantly associated with increased risk for development of ovarian cancer. |
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| Keywords: | Ovarian cancer Hyperinsulinemia Hypoadiponectinemia Non-diabetic women |
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