Cartap and carbofuran induced alterations in serum lipid profile of Wistar rats |
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| Authors: | Devendra K Rai Prashant Kumar Rai Aradhna Gupta Geeta Watal Bechan Sharma |
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| Institution: | (1) Department of Biochemistry, University of Allahabad, Allahabad, 211002, India;(2) Medicinal Research Lab, Department of Chemistry, University of Allahabad, Allahabad, 211002, India |
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| Abstract: | Wistar rats of 6–8 weeks in age weighing between 120–150 g were exposed to the fixed doses of each of the carbamate pesticides
such as cartap (50% LD50) and carbofuran (50% LD50) as well as a combination of these two with 25% LD50 of each for one week. The effect of treatments was studied in terms of serum lipid parameters such as high-density lipoprotein,
total cholesterol, triglyceride, low-density lipoprotein and very low-density lipoprotein. Treatment with individual doses
of carbofuran (50% LD50) and cartap (50 % LD50) caused significant alterations in the levels of serum lipid parameters. The pesticides treatment resulted in marked decrease
in the level of serum high-density lipoprotein where as that of other lipids got significantly elevated. Further, the rats
exhibited relatively higher impact of pesticides when treated with the compounds in combination (25 % LD50 of each). The results indicated that these compounds when used together may exert enhanced effect on the levels of serum
lipids in rat. |
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| Keywords: | Cartap Carbofuran Lipid Triglyceride Wistar rats |
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