A report on clinical importance of serum glycoconjugates in oral cancer |
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| Authors: | Bina R Baxi Prabhudas S Patel Siddharth G Adhvaryu |
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| Institution: | 1. Biochemistry Division Department of Cancer Biology, The Gujarat Cancer and Research Institute, Asarwa, 380 016, Ahmedabad, India
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| Abstract: | For evolving a potential Biochemical index for early diagnosis of oral cancer, serum levels of total sialic acid (TSA), lipid
bound sialic acid (LSA), mucoid proteins and hexoses (galactose and mannose) were determined in 30 patients with oral cancer.
The results were compared with similar values obtained for 30 patients with oral precancerous conditions, 24 healthy controls
and 15 normal individuals with a habit of tobacco chewing. All the biomarkers were significantly elevated in oral cancer patients
compared to the controls, the normal chewers and precancer patients. The levels of glycoconjugates showed significant increase
in patients with oral precancerous conditions compared to the controls. Only LSA and hexoses showed significantly elevated
levels in oral precancer patients compared to the normal chewers. The levels of glycoconjugates were more or less comparable
between normal chewers and the controls. The parameters evaluated in the oral cancer patients also showed a progressive rise
with the clinical stage of the malignant disease. The levels of the four glycoconjugates were also higher in patients with
metastasis compared to those with only primary disease. The present findings suggest that the glycoconjugates have clinical
utility in diagnosis of the patients with cancer of the oral cavity as well as in staging the disease. |
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