Session - 3 December 19, 2007 Cardiovascular risk markers - II |
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| Authors: | Cynthia Jane A V Nerurkar F R Karjodkar |
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| Institution: | (1) Department of Oral Medicine, Diagnosis and Radiology, Nair Hospital Dental College, Mumbai;(2) Dept of Biochemistry, T N Medical college, B.Y.L. Nair Hospital, 400008 Mumbai |
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| Abstract: | Oral Cancer is one of the five leading sites of cancer in Indian population. The circulating immune complexes were investigated
in 100 serum samples of 60 oral cancer patients having different grades of the disease and 40 patients with precancerous lesions
obtained from Nair Hospital Dental collage, Mumbai. The results obtained were compared with those of group of 40 healthy blood
donors. Elevated levels of Circulating Immune Complexes were observed in oral cancer patients and patients with oral precancerous
lesions. 92% positive samples were observed in well differentiated squamous cell carcinoma whereas 100% positive samples were
observed in both moderately and poorly differentiated squamous cell carcinoma. Oral leukoplakia and oral submucous fibrosis
showed 15% and 90% positivity respectively. Increased level of Circulating Immune complexes in high grade tumor suggest that
Circulating Immune complexes is likely to contribute in evaluating the degree of malignancy, but follow up study is needed
to draw any conclusion regarding it's prognostic role |
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| Keywords: | Oral cancer Circulating Immune complexes Squamous cell carcinoma Oral leukoplakia Oral submucous fibrosis |
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