Expression and significance of cyclin D1, p27kip1 protein in bronchioloalveolar carcinoma |
| |
| Authors: | Email author" target="_blank">Yuan?Jian-qunEmail author Xu?Jing-yao Zhang?Jing He?Qi-cai Zhu?Jia Sheng?Cai-xia |
| |
| Institution: | (1) Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 310016 Hangzhou, China |
| |
| Abstract: | Purpose: To investigate the relationship between expression of cell cycle-related protein cyclin D1, p27kip1 and the pathogenesis
of bronchioloalveolar carcinoma (BAC) and the value of prediction of prognosis. Methods: Cyclin D1 and p27kip1 protein were
detected by immunohistochemical En Vision method in 43 BACs. Results: The positivity of cyclin D1 in BAC was 65.1% (28/43),
which was significantly higher than that in normal pulmonary tissue (0/13),P<0.01. No statistically significant association was found between cyclin D1 expression data and sex, age, tobacco-use history,
histologic subtype (mucinous vs nonmucinous), stromal fibrosis, lymph node metastasis, clinical stage or postoperative survival
period (P>0.05), while cyclin D1 expression was found to be negatively correlated with tumor size (P<0.05). The positivity of p27kip1 in BACs was 51.2% (22/43), significantly lower than that in normal pulmonary tissue (12/13),P<0.01. p27kip1 expression level was not associated with sex, age, tobacco-use history, tumor size or histologic subtype (P<0.05), but was negatively correlated with stromal fibrosis, lymph node metastasis and clinical stage (P<0.05); and positively associated with postoperative survival period (P<0.01). The survival rate of p27kip1 positive group was significantly higher than that of p27kip1 negative group (P<0.01). No statistically significant correlation was found between cyclin D1 and p27kip1 expression. Conclusions: Increased
cyclin D1 expression and decreased p27kip1 expression are related to the pathogenesis of BAC; decreased p27kip1 expression
is associated with metastasis progression; immunodetection of p27kip1 is useful for assessment of prognosis. |
| |
| Keywords: | Adenocarcinoma Bronchioloalveolar Lung neoplasms Cyclin D1 p27kipl Immunohistochemistryction |
| 本文献已被 万方数据 SpringerLink 等数据库收录！ |
|
