Expression of TGF-β1 and TGF-β R II in colorectal adenomas of varying stages |
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| Authors: | Wang Da He Chao Ding Wei Wang Hui-ping |
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| Institution: | (1) First Affiliated Hospital, Medical College, Zhejiang University, 310003 Hangzhou, China;(2) Sir Run Run Shaw Hospital, Medical College, Zhejiang University, 310016 Hangzhou, China |
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| Abstract: | To study the function of transforming growth factor β1 (TGF-β1) and transforming growth factor-β type II receptor (TGF-βR II) in varying stages of colorectal adenoma during neoplastic
transformation, fiftyfive cases of resected colorectal adenomas were examined immunohistochemically. Our results showed that
the expression of TGF-β1 ranged from high to low, with the progression of low-grade to high-grade dysplasia of adenomas to carcinoma. And there was
significantly different expression of TGF-β1 between moderate and high dysplasia adenomas (P<0.05), but no significantly different expression of TGF-β R II was found among varying stages of adenomas. Our results suggested
that the quantities of TGF-β1 secreted by adenoma cells decrease dramatically in moderate to severe dysplasia colorectal adenomas. It is the decreased
secretion of TGF-β1, rather than the mutated TGF-βR II that may play an important role in transforming colorectal adenomas to adenocarcinomas. |
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| Keywords: | colorectal adenomas TGF-β 1 TGF-β R II immunohistochemistry |
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