Mechanism of acute pancreatitis complicated with injury of intestinal mucosa barrier |
| |
| Authors: | Zhang Xi-ping Zhang Jie Song Qiao-ling Chen Han-qin |
| |
| Institution: | (1) Department of General Surgery, Hangzhou First People’s Hospital, Hangzhou, 310006, China;(2) The First College of Clinical Medicine, Zhejiang University of Traditional Chinese Medicine, Hangzhou, 310053, China |
| |
| Abstract: | Acute pancreatitis (AP) is a common acute abdomen in clinic with a rapid onset and dangerous pathogentic condition. AP can
cause an injury of intestinal mucosa barrier, leading to translocation of bacteria or endotoxin through multiple routes, bacterial
translocation (BT), gutorigin endotoxaemia, and secondary infection of pancreatic tissue, and then cause systemic inflammatory
response syndrome (SIRS) or multiple organ dysfunction syndrome (MODS), which are important factors influencing AP’s severity
and mortality. Meanwhile, the injury of intestinal mucosa barrier plays a key role in AP’s process. Therefore, it is clinically
important to study the relationship between the injury of intestinal mucosa barrier and AP. In addition, many factors such
as microcirculation disturbance, ischemical reperfusion injury, excessive release of inflammatory mediators and apoptosis
may also play important roles in the damage of intestinal mucosa barrier. In this review, we summarize studies on mechanisms
of AP.
Project supported by the Traditional Chinese Medicine Science of Zhejiang Province (Nos. 2003C130 and 2004C142), the Medical
Science and Technology of Zhejiang Province (No. 2003B134), and the Technological Development of Hangzhou (No. 2003123B19),
China |
| |
| Keywords: | Acute pancreatitis (AP) Intestinal mucosa barrier Microcirculation disturbance Apoptosis Inflammatory mediators |
| 本文献已被 维普 PubMed SpringerLink 等数据库收录！ |
|
