| Review:Mechanism of acute pancreatitis complicated with injury of intestinal mucosa barrier |
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| 作者姓名： | ZHANG Xi-ping ZHANG Jie SONG Qiao-ling CHEN Han-qin |
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| 作者单位： | ZHANG Xi-ping1，ZHANG Jie2，SONG Qiao-ling2，CHEN Han-qin2 (1Department of General Surgery，Hangzhou First People’s Hospital，Hangzhou 310006，China) (2The First College of Clinical Medicine，Zhejiang University of Traditional Chinese Medicine，Hangzhou 310053，China) |
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| 基金项目： | Project supported by the Traditional Chinese Medicine Science of Zhejiang Province (Nos. 2003C130 and 2004C142)，the Medical Sci-ence and Technology of Zhejiang Province (No. 2003B134)，the Technological Development of Hangzhou (No. 2003123B19), China |
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| 摘 要： | Acute pancreatitis (AP) is a common acute abdomen in clinic with a rapid onset and dangerous pathogenetic condition. AP can cause an injury of intestinal mucosa barrier, leading to translocation of bacteria or endotoxin through multiple routes, bacterial translocation (BT), gutorigin endotoxaemia, and secondary infection of pancreatic tissue, and then cause systemic in- flammatory response syndrome (SIRS) or multiple organ dysfunction syndrome (MODS), which are important factors influencing AP’s severity and mortality. Meanwhile, the injury of intestinal mucosa barrier plays a key role in AP’s process. Therefore, it is clinically important to study the relationship between the injury of intestinal mucosa barrier and AP. In addition, many factors such as microcirculation disturbance, ischemical reperfusion injury, excessive release of inflammatory mediators and apoptosis may also play important roles in the damage of intestinal mucosa barrier. In this review, we summarize studies on mechanisms of AP.
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Review:Mechanism of acute pancreatitis complicated with injury of intestinal mucosa barrier |
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| ZHANG Xi-ping,ZHANG Jie,SONG Qiao-ling,CHEN Han-qin.Review:Mechanism of acute pancreatitis complicated with injury of intestinal mucosa barrier[J].Journal of Zhejiang University Science,2007(12). |
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| Authors: | ZHANG Xi-ping ZHANG Jie SONG Qiao-ling CHEN Han-qin |
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| Institution: | ZHANG Xi-ping1,ZHANG Jie2,SONG Qiao-ling2,CHEN Han-qin2 |
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| Abstract: | |
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| Keywords: | Acute pancreatitis (AP) Intestinal mucosa barrier Microcirculation disturbance Apoptosis Inflammatory mediators |
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