| Ferulic acid prevents liver injury and increases the anti-tumor effect of diosbulbin B in vivo |
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| 作者姓名： | Jun-ming WANG Yu-chen SHENG Li-li JI Zheng-tao WANG |
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| 摘 要： |
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| 收稿时间： | 2013 Sep 16 |
Ferulic acid prevents liver injury and increases the anti-tumor effect of diosbulbin B in vivo |
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| Jun-ming WANG,Yu-chen SHENG,Li-li JI,Zheng-tao WANG.Ferulic acid prevents liver injury and increases the anti-tumor effect of diosbulbin B in vivo[J].Journal of Zhejiang University Science,2014,15(6):540-547. |
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| Authors: | Jun-ming Wang Yu-chen Sheng Li-li Ji Zheng-tao Wang |
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| Abstract: | The present study is designed to investigate the protection by ferulic acid against the hepatotoxicity induced by diosbulbin B and its possible mechanism, and further observe whether ferulic acid augments diosbulbin B-induced anti-tumor activity. The results show that ferulic acid decreases diosbulbin B-increased serum alanine transaminase/aspartate transaminase (ALT/AST) levels. Ferulic acid also decreases lipid peroxide (LPO) levels which are elevated in diosbulbin B-treated mice. Histological evaluation of the liver demonstrates hydropic degeneration in diosbulbin B-treated mice, while ferulic acid reverses this injury. Moreover, the activities of copper- and zinc-containing superoxide dismutase (CuZn-SOD) and catalase (CAT) are decreased in the livers of diosbulbin B-treated mice, while ferulic acid reverses these decreases. Further results demonstrate that the mRNA expressions of CuZn-SOD and CAT in diosbulbin B-treated mouse liver are significantly decreased, while ferulic acid prevents this decrease. In addition, ferulic acid also augments diosbulbin B-induced tumor growth inhibition compared with diosbulbin B alone. Taken together, the present study shows that ferulic acid prevents diosbulbin B-induced liver injury via ameliorating diosbulbin B-induced liver oxidative stress injury and augments diosbulbin B-induced anti-tumor activity. |
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| Keywords: | Ferulic acid Diosbulbin B Hepatotoxicity Oxidative stress injury Anti-tumor activity |
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