| Imbalanced free radicals and antioxidant defense systems in schizophrenia： A comparative study |
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| 作者姓名： | Li HC Chen QZ Ma Y Zhou JF |
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| 作者单位： | Department of Psychiatry, the Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou 310009, China |
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| 摘 要： | Objective： To examine changes of blood oxidative-antiovidative level in schizophrenic patients and its relationship with clinical symptoms. Methods： Forty-six Chinese patients met DSM-IV （Diagnostic and Statistical Manual of Mental Disorders-iV） criteria for schizophrenia and fifty age- and sex-matched healthy controls were enrolled in the present study. Baseline psychiatric symptom severity was assessed with brief psychiatric rating scale, positive and negative syndrome scale on the blood draw day. Fresh blood samples were collected to measure levels of nitric oxide and lipid peroxide in plasma as well as activities of superoxide dismutase, catalase and glutathione peroxidase in red blood cells by spectrophotometric assays simultaneously. Results Comparison of the biochemical parameters indicated that the level of nitric oxide and lipid peroxide increased in patient group, which represented a positive correlation with positive scale scores; while the activities of three critical enzymes decreased and showed a negative linear correlation. Conclusion： This study showed that there are dysregulation of free radical metabolism and poor activities of the antioxidant defense systems in schizophrenic patients. Excess free radicals formation may play a critical role in the etiology of schizophrenia. Using antioxidants might be an effective therapeutic approach to partially alleviate or prevent the symptoms of schizophrenia.
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| 关 键 词： | 精神分裂症 一氧化氮 脂质过氧化物 谷胱甘肽过氧化物酶 |
| 收稿时间： | 2006-05-26 |
| 修稿时间： | 2006-09-18 |
Imbalanced free radicals and antioxidant defense systems in schizophrenia: A comparative study |
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| Li HC,Chen QZ,Ma Y,Zhou JF.Imbalanced free radicals and antioxidant defense systems in schizophrenia: A comparative study[J].Journal of Zhejiang University Science,2006,7(12):981-986. |
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| Authors: | Hui-chun Li Qiao-zhen Chen Ying Ma Jun-fu Zhou |
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| Institution: | (1) Department of Psychiatry, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China |
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| Abstract: | Objective: To examine changes of blood oxidative-antiovidative level in schizophrenic patients and its relationship with clinical symptoms. Methods: Forty-six Chinese patients met DSM-IV (Diagnostic and Statistical Manual of Mental Disor- ders-IV) criteria for schizophrenia and fifty age- and sex-matched healthy controls were enrolled in the present study. Baseline psychiatric symptom severity was assessed with brief psychiatric rating scale, positive and negative syndrome scale on the blood draw day. Fresh blood samples were collected to measure levels of nitric oxide and lipid peroxide in plasma as well as activities of superoxide dismutase, catalase and glutathione peroxidase in red blood cells by spectrophotometric assays simultaneously. Results: Comparison of the biochemical parameters indicated that the level of nitric oxide and lipid peroxide increased in patient group, which represented a positive correlation with positive scale scores; while the activities of three critical enzymes decreased and showed a negative linear correlation. Conclusion: This study showed that there are dysregulation of free radical metabolism and poor activities of the antioxidant defense systems in schizophrenic patients. Excess free radicals formation may play a critical role in the etiology of schizophrenia. Using antioxidants might be an effective therapeutic approach to partially alleviate or prevent the symptoms of schizophrenia. |
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| Keywords: | Schizophrenia Nitric oxide (NO) Lipid peroxide (LPO) Glutathione peroxidase (GSH-Px) Catalase (CAT) Superoxide dismutase (SOD) Symptom |
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