| 黄芩甙对肝损伤小鼠肝抗氧化功能影响的研究 |
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| 引用本文： | 龚争,程郁昕,章敏,宋婷婷,吕锦芳,宁康健.黄芩甙对肝损伤小鼠肝抗氧化功能影响的研究[J].安徽科技学院学报,2011,25(1):5-8. |
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| 作者姓名： | 龚争 程郁昕 章敏 宋婷婷 吕锦芳 宁康健 |
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| 作者单位： | 安徽科技学院,动物科学学院,安徽,凤阳,233100;安徽科技学院,动物科学学院,安徽,凤阳,233100;安徽科技学院,动物科学学院,安徽,凤阳,233100;安徽科技学院,动物科学学院,安徽,凤阳,233100;安徽科技学院,动物科学学院,安徽,凤阳,233100;安徽科技学院,动物科学学院,安徽,凤阳,233100 |
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| 基金项目： | 安徽省科技厅年度重点项目 |
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| 摘 要： | 目的:观察黄芩甙注射液对四氯化碳(CCl4)致急性肝损伤小鼠肝抗氧化功能的影响。方法:50只小鼠随机分为5组,每组10只,分别为对照组、模型组、黄芩甙注射液低、中、高(0.25 g/kg、0.50 g/kg、1.00g/kg)剂量组。用CCl4制备小鼠急性肝损伤模型,测定小鼠体重变化,肝指数,肝超氧化物歧化酶(SOD)及谷胱甘肽过氧化物酶(GSH-Px)活性,谷胱甘肽(GSH)及丙二醛(MDA)含量。结果:与对照组及模型组比较,黄芩甙各剂量组小鼠试验前后的体重及肝指数差异不显著(P>0.05)。与模型组比较,低剂量组小鼠肝SOD、GSH-Px活性及MDA含量差异不显著(P>0.05),而GSH含量显著升高(P<0.05);中、高剂量组SOD、GSH-Px活性极显著提高(P<0.01),GSH含量极显著升高(P<0.01),MDA含量极显著降低(P<0.01)。结论:黄芩甙能显著增强急性肝损伤小鼠肝SOD、GSH-Px活性,提高GSH含量,降低MDA含量,并表现正向的量效关系。
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| 关 键 词： | 黄芩甙 小鼠 肝损伤 超氧化物歧化酶 谷胱甘肽过氧化物酶 谷胱甘肽 丙二醛 |
Effects of Baicalin on Anti-oxidation Function in Liver of Liver Injury Mice |
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| GONG Zheng,CHENG Yu-xin,ZHANG Min,SONG Ting-ting,LV Jin-fang,NING Kang-jian.Effects of Baicalin on Anti-oxidation Function in Liver of Liver Injury Mice[J].Journal of Anhui Science and Technology University,2011,25(1):5-8. |
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| Authors: | GONG Zheng CHENG Yu-xin ZHANG Min SONG Ting-ting LV Jin-fang NING Kang-jian |
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| Institution: | (College of Animal Science,Anhui Science and Technology University,Fengyang 233100,China) |
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| Abstract: | Objective: To observe the effects of baicalin injection on anti-oxidation function in mice liver of the acute liver injury induced by carbon tetrachloride(CCl4).Method: 50 mice were randomly divided into five groups,10 mice every group,while the groups were the control group,the model group,and the baicalin groups at low,middle and high doses(0.25g/kg,0.50g/kg,1.00g/kg) respectively.The acute liver injury model of mice were induced by CCl4,the body weight,the liver index,the activity of SOD and GSH-Px,and the content of GSH and MDA of mice were determined.Results: There were not significant differences(P>0.05) of the body weight and the liver index of mice among five groups.Comparing with the model group,the activity of SOD and GSH-Px,and the content of MDA in liver of mice,which in the baicalin group at low dose,were not significantly differences(P>0.05),but the content of GSH increased significantly(P<0.05).Comparing with the model group,the activity of SOD and GSH-Px in liver of mice,which in the baicalin groups at middle and high doses,increased very significantly(P<0.01),the content of GSH increased very significantly(P<0.01),and the content of MDA decreased very significantly(P<0.01).Conclusion: Baicalin could significantly increase the activity of SOD and GSH-Px in liver of mice with acute liver injury,increase the content of GSH,and decrease the content of MDA,and there was a positive relationship between dose and effect. |
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| Keywords: | Baicalin Mice Liver injury SOD GSH-Px GSH MDA |
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