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| Ki-67在肝细胞肝癌中的表达及其临床意义 | |
| 引用本文： | 王凝芳,赵荣宇,冯雪冬,吕盼盼,张黎.Ki-67在肝细胞肝癌中的表达及其临床意义[J].大连大学学报,2003,24(2):71-73,79. |
| 作者姓名： | 王凝芳 赵荣宇 冯雪冬 吕盼盼 张黎 |
| 作者单位： | 1. 大连医科大学,附属一院介入科,辽宁,大连,116001 2. 大连医科大学附属一院外科,辽宁,大连,116001 3. 浙江医科大学,浙江,杭州,310031 |
| 摘 要： | 目的]探讨抗增殖核蛋白的单克隆抗体(Ki-67)在肝细胞肝癌(HCC)中的表达情况及临床意义.方法]采用免疫组织化学方法检测51例HCC病人术后存档的石蜡标本中Ki-67的表达情况.结果]HCC中Ki-67阳性表达率58.8％.Ki-67表达阳性率与肿瘤大小、门脉癌栓和肿瘤分级相关,与肝硬化、病灶数目、包膜、AFP及HBsAg不相关,Ki-67阳性表达组HCC病人术后无瘤生存期均显著低于阴性表达组.结论]Ki-67对HCC的浸润转移均起促进作用,是HCC预后的重要标志物. |
| 关 键 词： | 肝细胞肝癌 免疫组织化学 Ki-67 复发 转移 |
| 文章编号： | 1008-2395(2003)02-0071-04 |
Expression of Ki-67 in hepatocellular carcinoma and its clinical signgicance |
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| WANG Ningfang,ZHAO rong-yu.Expression of Ki-67 in hepatocellular carcinoma and its clinical signgicance[J].Journal of Dalian University,2003,24(2):71-73,79. | |
| Authors: | WANG Ningfang ZHAO rong-yu |
| Abstract: | Objective] To explore the expression of Ki-67 in HCC and its clinical signifiance. Methods] Expression of Ki-67 was detected immunohistochemically in paraffinmbedded samples of 51 HCC. Results] 58.8% HCC samples show postive Ki-67 expression. Significant difference has been found between ki-67 expression and tumor size, portal vein embolus and grading, and no significant difference has been found between Ki- 67 expression and the unmber of tumors, liver cirrhosis, capsule formation, AFP, and the status of HBsAg. The patients postoperative disease-free survival in the group of postiveKi-67 expression is significantly shorter than that of negtive Ki-67 expression. Conclusion] Ki-67 can promote the reccurence and metastatic plotential of HCC and is an important prognostic factor of patients with HCC. |
| Keywords: | hepatocelluar carcinoma immunohistochemistry Ki-67 reccurence metastasis |
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