| 碳源对阿维拉霉素产量影响的研究 |
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| 引用本文： | 刘宁,王永星,张海龙,张召佐,关志勇.碳源对阿维拉霉素产量影响的研究[J].山东教育学院学报,2008,23(4):82-84. |
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| 作者姓名： | 刘宁 王永星 张海龙 张召佐 关志勇 |
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| 作者单位： | 1. 山东胜利股份有限公司生物产业部,山东,济南,250101
2. 山东教育学院生物科学与技术系,山东,济南,250013 |
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| 摘 要： | 阿维拉霉素（卑霉素）是由绿色产色链霉菌（Streptomyces viridocbromogene，sv）发酵得到的寡糖类抗生素。本文研究了碳源，主要是葡萄糖和可溶性淀粉对阿维拉霉素产量的影响。葡萄糖是SV快速利用的碳源，研究发现大于20g/L的初始葡萄糖浓度强烈抑制阿维拉霉素的积累，可溶性淀粉是促进产物积累的有效碳源，但高于40g/L的初始可溶性淀粉浓度影响其转化率。在此基础上，设计碳源补加工艺，提高了阿维拉霉素的产量，其中以可溶性淀粉为基础碳源，培养过程中补加葡萄糖，培养240小时，阿维拉霉素的产量达到1926μg／ml。
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| 关 键 词： | 阿维拉霉素 发酵 碳源 |
Study on the influence of carbon source on avilamycins potency |
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| Liu Ning,Wang Yongxing,Zhang Hailong,Zhang Zhaozuo,Guan Zhiyong.Study on the influence of carbon source on avilamycins potency[J].Journal of Shandong Education Institute,2008,23(4):82-84. |
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| Authors: | Liu Ning Wang Yongxing Zhang Hailong Zhang Zhaozuo Guan Zhiyong |
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| Institution: | Liu Ning Wang Yongxing Zhang Hailong Zhang Zhaozuo Guan Zhiyong (1. Department of Bioindustry , Shandong Shengli Co., LTD., Jinan 250101, China ; 2. Department of Bioseienee and Bioteehnology, Shandong Education Institute, Jinan 250013, China ) |
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| Abstract: | The avilamycins are oligosaccharide antibiotics which produced by Streptomyces viridocbromogene(sv) fermentation.This paper is to study the influence of carbon sources,mainly glucose and soluble starch,on avilamycins potency.Glucose is a kind of quick using carbon source.The study finds that more than 20g/L the initial glucose concentration strongly inhibits the accumulation of avilamycins.Soluble starch is an effective carbon source which promotes the avilamycins accumulation.But more than 40g/L the initia... |
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| Keywords: | avilamycins fermentation carbon source |
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