| Survivin在原发性肝癌组织中的表达及其临床意义 |
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| 引用本文： | 许燕,卢顺麟.Survivin在原发性肝癌组织中的表达及其临床意义[J].泰州职业技术学院学报,2013(6):60-61,64. |
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| 作者姓名： | 许燕 卢顺麟 |
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| 作者单位： | [1]泰州职业技术学院医学技术学院 [2]泰州市第四人民医院,江苏泰州225300 |
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| 摘 要： | 目的 研究Survivin在原发性肝细胞癌中的表达水平及其临床意义,探讨其表达水平与原发性肝细胞癌发生发展的关系.方法 将101例原发性肝细胞癌及32例正常肝组织标本用免疫组化SP法检测Survivin的表达.结果 Survivin在原发性肝细胞癌组织中的表达明显高于正常肝组织中,差异具有统计学意义（p＜0.05）;在原发性肝癌中,Survivin的表达与肿瘤的淋巴结转移以及肿瘤的分化程度显著相关（p＜0.05）.结论 Survivin在原发性肝癌中的表达与肿瘤的发生发展有关,Survivin可作为判断原发性肝癌预后的指标之一.
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| 关 键 词： | Survivin 原发性肝癌 免疫组化 |
The Expression and Clinical Significance of Survivin in Primary Hepatocellular Carcinoma |
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| XU Yan,LU Shun-lin.The Expression and Clinical Significance of Survivin in Primary Hepatocellular Carcinoma[J].Journal of Taizhou Polytechnical Institute,2013(6):60-61,64. |
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| Authors: | XU Yan LU Shun-lin |
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| Institution: | 1. Taizhou Polytechnic College; 2. The Fourth People＇s Hospital of Taizhou, Taizhou Jiangsu 225300, China) |
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| Abstract: | Objective To investigate the expression of Survivin in primary hepatocellular carcinoma （HCC）and its clinical significance, analyze their relationships with carcinogenesis and progression of liver cancer. Methods SP immunohistochemistry method was used to detect the expressions of Survivin in 101 HCC cases and 32 normal liver tissue. Results The expression level of Survivin in the HCC tissues was significantly higher than that in nor- mal tissue group （p〈0.05）. In the group of HCC, Survivin expression was significant correlated with lymphnode metastasis and histological grade （p〈0.05）. Conclusion The expression of Survivin was significant correlated with carcinogenesis and progression of HCC,It may be a reliable indicator to judge the prognosis of primary hepatocel- lular carcinoma. |
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| Keywords: | Survivin primary hepatoceUular carcinoma immunohistochemistry |
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