共查询到19条相似文献,搜索用时 421 毫秒
1.
玉叶清火缓释片的体外释放度测定 总被引:2,自引:0,他引:2
建立玉叶清火缓释片的体外释放度测定方法。方法:采用转篮法,以蒸馏水为溶出介质,转速为100r/min,测定波长为246nm。结果:穿心莲内酯对照品在0.003~O.015mg/mL范围内浓度与吸收度的线性关系良好,r=0.999.RSD=0.266%(n=3)。玉叶清火片普通片释药80%约需时1.5h,玉叶清火片缓释片释药50%则需要3.5h左右。结论:该方法操作简便、准确可靠,可用于玉叶清火缓释片的质量控制。玉叶清火片缓释片比普通片具有明显的缓释特点,基本能满足临床治疗需要。 相似文献
2.
目的:采用高效液相色谱法测定普伐他汀钠胶囊的溶出度。方法:按照《中国药典》2005年版Ⅱ部溶出度测定法中的第二法,以水900ml为溶剂,转数为50r min-1,30min时采样。采样后以高效液相色谱法测定。色谱柱:DiamonsilTM C18(200min×4.60 mm,5μm),流动相:磷酸盐缓冲液甲醇(40:60)pH3.5±0.05,流速:1.0ml*min-1,检测波长:238 nm,以外标法测定普伐他汀钠胶囊的溶出度。结果:线性范围为3.0—12.0 μm-1(r=0.9999)。平均回收率为99.86%,(RSD=1.7%,n--6),溶出度符合规定。结论:该方法简便、易行。结果准确。 相似文献
3.
目的:建立测定阿莫西林片溶出度的方法。方法:照《中国药典》2010年版二部溶出度测定第二法,以水900mL为溶出介质,转速75转/分,30分钟取样,用紫外-可见分光光度法测定溶出量,检测波长为272nm。结果:阿莫西林在91.16-120.28ug/ml浓度范围内吸光度线性关系良好(r=0.9998,n=6),,平均回收率为99.05%(RSD=0.26%)。结论:本方法简便,准确可靠,能满足质量控制的要求。 相似文献
4.
建立反相高效液相色谱法测定替硝唑素片、替硝唑薄膜衣片、替硝唑胶囊中替硝唑的含量并考察溶出度。方法:采用安捷伦C18色谱柱(218 mm×4.6mm,5μm),0.025M磷酸二氢钾缓冲液(含0.3%三乙胺,用磷酸调pH3.5):乙腈:甲醇(55∶20∶25),检测波长为318nm,流速为1.0ml/min,柱温为30℃。替硝唑在3~72μg.mL-1范围内呈良好的线性关系(r=0.99992)。替硝唑平均回收率分别为99.5%、99.3%、99.1%。结论:本法简便、准确,可用于替硝唑素片、替硝唑薄膜衣片、替硝唑胶囊中替硝唑的含量测定。 相似文献
5.
本实验研究利福平腱囊的制备方法并建立反相高效液相色谱法测定利福平胶囊中利福平的含量。方法:采用安捷伦十八烷基硅烷键合硅胶色谱柱(218mm×4.6mm,5μm),甲醇-0.02mol/L磷酸氢二钠一磷酸(80:20:0.01),检测波长为254啪,流速为1.0ml/min,柱温为30℃。利福平在50~500μg·mL^-1%范围内呈良好的线性关系(r=0.9999)。结论:本制剂稳定、可靠、溶出度好。 相似文献
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7.
建立电感耦合等离子体质谱(ICP-MS)法同时测定木碗中有害重金属迁移量的方法。以4%HCL作为浸泡液,于30℃恒温培养箱中放置24h作为前处理条件,电感耦合等离子体质谱作为检测手段,同时测定木碗中铅(Pb)、砷(As)、汞(Hg)、镉(Cd)、铬(Cr)的迁移量。Pb、As、Hg、Cd、Cr线性关系良好(r≥0.9995),方法检出限为0.001mg/kg-0.0015mg/kg,方法回收率为91.3%-96.8%,RSD为1.2%-5.1%。本法简便、准确、灵敏度高,重复性好,适用于进出口木碗食具容器的日常检验。 相似文献
8.
《黑龙江科技信息》2017,(13)
目的:考察五加缓释微丸的稳定性,确定其稳定条件。方法:以滴制法制备刺五加缓释微丸,并通过影响因素试验、加速试验、长期试验考察微丸的外观、体外累积释放度及紫丁香苷的含量。结果:(1)在影响因素试验中,刺五加缓释微丸均未发生突释现象;高温条件下,囊壳逐渐变硬,1h、12h体外累积释放度分别下降3.44%、5.29%,紫丁香苷含量下降1.08%;高湿条件下,囊壳逐渐变软,1h、12h体外累积释放度分别下降7.46%、6.52%,紫丁香苷含量下降1.68%;强光照条件下,囊壳逐渐变硬,1h、12h体外累积释放度分别下降4.02%、5.61%,紫丁香苷含量下降1.10%。(2)在加速试验中,3个批次的样品均未发生突释现象,外观均符合规定,1h、12h体外累积释放度、紫丁香苷含量有所下降,但均不低于限度。结论刺五加缓释微丸不宜在高温、高湿、强光照条件下贮存;在40℃±2℃,相对湿度为75%±5%的条件下,刺五加缓释微丸也较为稳定;在25℃±2℃,相对湿度60%±5%的环境下。 相似文献
9.
定血塞通胶囊中人参皂苷Rg1、Rb1和三七皂苷R1的含量测定 总被引:1,自引:0,他引:1
建立反相高效液相色谱法测定定血塞通胶囊中人参皂苷Rg1、Rb1、三七皂苷R1的含量。方法:采用Hypersil BDS C18反相色谱柱(5μm,4.6mm×250mm)乙腈和水梯度洗脱,检测波长为203nm,流速为1.0ml/min,柱温为35℃。人参皂苷Rg1在2.56~15.36μg范围内呈良好的线性关系(r=0.9995)。人参皂苷Rg1平均回收率为98.12%。人参皂苷Rb1在2.64~15.84μg范围内呈良好的线性关系(r=0.9997)。人参皂苷Rb1平均回收率为98.96%。三七皂苷R1在0.6~3.6μg范围内呈良好的线性关系(r=0.9998)。三七皂苷R1平均回收率为99.26%。结论:本法简便、准确,可用于定血塞通胶囊中人参皂苷Rg1、Rb1和三七皂苷R1的含量测定。 相似文献
10.
建立气相色谱法测定布洛芬胶囊中布洛芬的含量。方法:石英毛细管柱(0.53min×1.0μm,30m,SE-30);载气:氮气;汽化室温度220℃;检测器温度260℃;柱温200℃。进样量:1μl,分流比1:8;定量方法:内标峰面积法。布洛芬在0.5—8mg·mL-1。范围内呈良好的线性关系(r=0.99996)。布洛芬平均回收率分别为99.6%。结论:本法简便、准确,可用于布洛芬的含量测定。 相似文献
11.
建立注射用盐酸头孢吡肟含量测定的RP-HPLC方法。ODS色谱柱250×4.6mm(i.d.)5μm;0.04mol/L醋酸铵(冰醋酸调节pH至5.0)-甲醇(92:8)为流动相,流速为1.0ml/min,检测波长为256nm。流速为1.0ml/min。盐酸头孢吡肟在10.5~84.0μg/ml浓度范围内,其峰面积与浓度呈良好线性关系(r=0.9993),精密度RSD为0.5%。平均回收率为98.90%,RSD为0.34%,检测限为1.5ng。本法简便、快速、准确、专属性强,可用于注射用盐酸头孢吡肟的含量测定及有关物质检查。 相似文献
12.
Background
The preanalytical phase represents the major source of variability in laboratory diagnostics. Our aim was to assess to what extent underfilling of primary blood tubes may impact upon routine coagulation testing.Materials and methods:
Blood was drawn by syringe from 21 healthy volunteers and 6 patients on warfarin therapy, and immediately transferred into 3.6 mL vacuum tubes containing 3.2% sodium citrate (Terumo Europe N.V., Leuven, Belgium). All tubes were filled using standardized volumes of whole blood to produce scalar amounts of filling: 3.6 mL (i.e., 100%), 3.2 mL (89%), 2.8 mL (78%) and 2.4 mL (67%). Samples were mixed and centrifuged at 1300 × g for 10 min. The plasma was tested for prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen (FBG) on ACL TOP (Instrumentation Laboratory - IL, Milan, Italy), using IL reagents. A polynomial plot was derived for each parameter from interpolation of clotting values obtained with different percentages of filling, and these plots were compared with quality specifications (± 2.0 for PT, ± 2.3 for APTT and ± 4.8 for FBG) to calculate the minimal filling volume required to produce clinically acceptable results.Results:
The equations were (PF, Percentage of filling): PT (sec) = 3.375 × PF^2–6.255 × PF + 17.806 (r = 0.980); APTT (sec) = 8.925 × PF^2–23.578 × PF + 46.356 (r = 0.979); and FBG (mg/dL) = −311.5 × PF^2 + 422.1 × PF + 147.07 (r = 0.994). According to these equations, the minimum allowed thresholds of blood tubes filling were > 61% for PT, > 87% for APTT and > 71% for FBG.Conclusions:
Our results confirm that routine coagulation testing performed on underfilled tubes may generate biased and clinically misleading test results. This is particularly critical for APTT, wherein tubes filled at less than ∼90% generate unreliable data. The FBG and the PT seem more resistant to underfilling, clinical significant biases being observed only where blood tubes were filled at less than ∼60 and ∼70%, respectively. 相似文献13.
风电场风速预报集合订正方法的尝试性研究 总被引:1,自引:0,他引:1
以中国气象局风能太阳能资源评估中心风能预报系统(WINPOP)预报的甘肃HYZ和GHK两个风电场2012年大风月风速预报结果为基础,利用BP神经网络法(简称BP法)和自适应最小二乘法(简称LS法),采用两种训练样本构建方案对风电场风速预报进行订正试验,并尝试性使用神经网络集合方法对订正后的风速进行集合订正试验.结果发现:①经BP法和LS法等的直接统计订正及其集合订正后风电场风速预报效果明显优于WINPOP直接预报效果,且集合订正效果优于任何一种单一的统计订正;②与WINPOP直接预报相比,单一的统计订正及其集合订正都能较好地消除系统误差;③与单一的统计订正相比,集合订正具有更为明显的平均误差小、好日子率高、风速预报日变化幅度误差小等优势;④无论是HYZ风电场还是GHK风电场,随着预报时效的增加,各种预报(或订正)误差无显著差别.各种预报或订正方法的预报误差均随风速的增大而先减小后增大,随3h气压变量的增加而增大. 相似文献
14.
目的:用高效液相色谱法测定甲硝唑芬布芬胶囊的含量。方法:用十八烷基硅烷键合硅胶为填充剂;以甲醇-乙腈-水(40:60:40)(用磷酸调节pH值至3.0)为流动相;检测波长为300nm;流速为1.0ml/min。结果:该方法在0.04080-0.2040mg/ml范围内,甲硝唑峰面积与质量浓度呈良好的线性关系。线性方程为y=3.8114E-08x-1.4259E-04,线性相关系数r=0.99999,在0.03024~0.1512mg/ml范围内,芬布芬峰面积与质量浓度呈良好的线性关系。线性方程为y=2.5272E-08x—1.7078E-03,线性相关系数r=-0.9999,回收率为99.2%和99.6%,重复性实验RSD=0.18%、RSD=0.23%(n=5)。结论:方法简便,快速,准确,适用于该产品质量控制。 相似文献
15.
目的探讨肾石通颗粒质量标准。采用HPLC法对肾石通颗粒中的丹酚酸B进行含量测定。方法:色谱柱为Kromasil C18色谱柱(4.6×250mm;5um),以甲醇-乙腈-甲酸-水(30:10:1:59)为流动相;流速:1.0ml.min-1,检测波长286nm。结果:丹酚酸B的进样量在0.2~1.2ug范围内呈良好的线性关系(r=0.9999),平均加样回收率为99.78%,RSD为0.09%(n=6)。结论:方法简便、准确,可用于肾石通颗粒中丹酚酸B的含量测定。 相似文献
16.
目的:用高效液相色谱法测定氨苄西林胶囊的含量。方法:采用Diamond ODS C18柱(150×4.6mm,5um);流动相A为12%醋酸溶液-0.2mol/L磷酸二氢钾溶液-乙腈-水(0.5:50:50:900)流动相B为12%醋酸溶液-0.2mol/L磷酸二氢钾溶液-乙腈-水(0.5:50:400:550),以流动相A-流动相B(85:15)为流动相;流速1.0ml/min;检测波长254nm;柱温40℃。结果:氨苄西林的线性范围为7.382~366.4μg/ml,r=0.9996,回收率为98.74%(RSD=0.6%)。结论:本法方便、快速、准确,可用于氨苄西林胶囊的质量控制。 相似文献
17.
目的:建立百令颗粒质量标准的测定方法。方法:色谱柱为迪马C184.6×250mm,5μ;柱温:室温;流动相:0.04mol/L磷酸二氢钾-乙腈(95:5),流速1.0ml/min,检测波长260nm。结果:百令颗粒制剂能较好的分离,且线性良好(r=1),表明腺苷在0.02μg~0.22μg范围内具有良好线性关系。平均回收率(n=6)为98.53%,相对标准偏差1.33%;样品溶液在12小时内稳定。结论:方法简便,重复性好,适用于该产品含量测定。 相似文献
18.
Michael C. Motal Daniel A. Klaus Diana Lebherz-Eichinger Bianca Tudor Thomas Hamp Marion Wiegele Rudolf Seemann Claus G. Krenn Georg A. Roth 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2015,25(1):90-96
Introduction
Vaspin (visceral adipose tissue-derived serpin) was first described as an insulin-sensitizing adipose tissue hormone. Recently its anti-inflammatory function has been demonstrated. Since no appropriate data is available yet, we sought to investigate the plasma concentrations of vaspin in sepsis.Materials and methods
57 patients in intensive care, fulfilling the ACCP/SCCM criteria for sepsis, were prospectively included in our exploratory study. The control group consisted of 48 critically ill patients, receiving intensive care after trauma or major surgery. Patients were matched by age, sex, weight and existence of diabetes before statistical analysis. Blood samples were collected on the day of diagnosis. Vaspin plasma concentrations were measured using a commercially available enzyme-linked immunosorbent assay.Results
Vaspin concentrations were significantly higher in septic patients compared to the control group (0.3 (0.1-0.4) ng/mL vs. 0.1 (0.0-0.3) ng/mL, respectively; P < 0.001). Vaspin concentration showed weak positive correlation with concentration of C-reactive protein (CRP) (r = 0.31, P = 0.002) as well as with SAPS II (r = 0.34, P = 0.002) and maximum of SOFA (r = 0.39, P < 0.001) scoring systems, as tested for the overall study population.Conclusion
In the sepsis group, vaspin plasma concentration was about three-fold as high as in the median surgical control group. We demonstrated a weak positive correlation between vaspin and CRP concentration, as well as with two scoring systems commonly used in intensive care settings. Although there seems to be some connection between vaspin and inflammation, its role in human sepsis needs to be evaluated further.Key words: adipocytokine, inflammation, vaspin, CRP, intensive care 相似文献19.
Küme T Sişman AR Solak A Tuğlu B Cinkooğlu B Coker C 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(2):189-201