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1.
P. Subash 《Indian journal of clinical biochemistry : IJCB》2016,31(2):185-193
The objective of the present study was to investigate the antioxidant status and the extent of oxidative DNA damage in lymphocytes and their relation with essential hypertension (EHT). A total of 100 South Indian subjects aged 30–65 were included for the study. Of these 50 were normotensive controls (group-1) with blood pressure ≥120/80 mm Hg, 50 were newly diagnosed (group-2) and were not on any antihypertensive drugs, but had systolic blood pressure ranging between 140 and 160 mmHg and diastolic blood pressure 95–100 mmHg and 50 newly diagnosed essential hypertensive patients underwent drug therapy for 1 year was considered as group-3. Enzymatic and non-enzymatic antioxidants significantly decreased and lymphocyte DNA damage was significantly increased in newly diagnosed hypertensive patients compared with control group. The major decrease in DNA damage and significant improvement in enzymatic and non-enzymatic antioxidants were observed after 1 year of antihypertensive therapy in treated group compared with newly diagnosed hypertensive patients. Total antioxidant status and lymphocyte DNA damage showed a strong negative correlation in all the three groups. Essential hypertension associated with oxidative stress which in turn causes genotoxic susceptibility to variety of disease including cancer. In the absence of DNA repair process and DNA checkpoint mechanisms, the genomic integrity is susceptible to extensive damage. In our study, increased oxidative DNA damage and decreased antioxidant levels were frequently observed in the newly diagnosed essential hypertensive patients, suggesting that oxidative stress is important in the pathogenesis of EHT. Therefore, the present study has additional clinical implication. Further investigations with large number of patients along with antioxidant supplement are highly warranted. 相似文献
2.
P. Subash Prema Gurumurthy A. Sarasabharathi K. M. Cherian 《Indian journal of clinical biochemistry : IJCB》2010,25(2):127-132
Establishment of non-invasive urinary biomarker for the early prediction of essential hypertension (EH) is important. We evaluated
whether estimation of urinary DNA, serves as a marker to predict the extent of cellular oxidative stress in essential hypertension.
A total of 180 South Indian subjects aged 30–65 were recruited for the study. Of these hypertensive subjects investigated,
30 were newly diagnosed and were not on any antihypertensive drugs, but had systolic blood pressure 140–160 mmHg and diastolic
blood pressure 95–100 mmHg and 75 hypertensive patients who already on drug therapy for one year and 75 were South Indian
normotensive healthy controls with blood pressure ≤ 120/80 mmHg. The 8-OHdG level in urine was significantly increased in
hypertensive patients (both newly diagnosed and who already on drug therapy) compared with control group. The significant
increase in 8-OHdG was observed in newly diagnosed hypertensive patients compared with hypertensive patients who already on
drug therapy. There was a significant decrease in serum TAS value in essential hypertensive group when compared to control
group. The urinary 8-OHdG was independently correlated with serum TAS. Decreased TAS levels, which reflect to increased oxidative
stress, may be the reason of increased urinary 8-OHdG in South Indian hypertensive patients. Our preliminary data suggest
that the competitive ELISA for 8-OHdG appears to be a simple method for quantifying the extent of oxidative stress. 相似文献
3.
Role of Vitamin D supplementation was studied in patients with hypertension. One hundred hypertensive patients (group I) were
given conventional antihypertensive drugs while another 100 patients (group II), in addition, were supplemented with Vitamin
D3 (33,000 IU, after every 2 weeks, for 3 months). Besides diastolic and systolic blood pressure, serum calcium, phosphorous,
alkaline phosphatase, albumin, albumin-corrected calcium, and 24 h urinary creatinine levels were estimated in both the groups
before the start of treatment and after 3 months. Vitamin D supplementation showed a more significant decrease in systolic
blood pressure. This group also showed a significant increase in serum calcium as well as albumin-corrected calcium with a
decrease in phosphorous. Results of the study confirm that Vitamin D supplementation has a role in reducing blood pressure
in hypertensive patients and that it should be supplemented with the antihypertensive drugs. More extensive studies with a
larger group, to draw a definite conclusion, are in progress. 相似文献
4.
门诊和住院病人抗高血压药物用药情况及依从性调查 总被引：6，自引：0，他引：6
目的：为探讨高血压住院和门诊患者降压药物的依从性及其相关因素；了解降压药物的用药情况。方法：回顾性分析1997年12月至2001年10月高血压病住院患者408例和门诊随访患者249例的降压药物依从性及其相关因素；调查降压药物的使用情况和药物副作用的发生率；观察药物依从者和不依从者的血压水平变化。结果：高血压住院病人的心血管危险因素，住院期间的药物依从率为63．5％，出院时出院药的依从率77．1％，门诊随访期间的药物依从性为43．4％，结论：出院后对出院带药的依从性最佳，住院期间的药物依从性次之，门诊随访期间的药物从性最差，门诊随访期间钙拮抗剂和利尿剂的副作用明显增多，药物依从者血压的波动小，药物不依从者血压的波动大。 相似文献
5.
K. Sudhakar M. Sujatha S. Ramesh Babu P. Padmavathi P. P. Reddy 《Indian journal of clinical biochemistry : IJCB》2004,19(1):21-23
Calcium plays an important role in the pathophysiology of essential hypertension. Serum calcium levels were measured in 117
subjects with essential hypertension and 77 first-degree relatives. The results showed that serum calcium levels were significantly
(p<0.01) decreased in both males and females with essential hypertension and their first-degree relatives when compared with
the normotensive controls. This is the first study in Indian population. 相似文献
6.
Servin Yeşil Günal Bilal Üstündağ Ali İhsan Günal 《Indian journal of clinical biochemistry : IJCB》2013,28(4):390-395
The aim of this study is to evaluate the oxidative stress in predialysis, hemodialysis (HD) and peritoneal dialysis patients and to test the effects of antihypertensive drugs and volume control on oxidative stress parameters. The study was composed of five groups as follows: control group (n = 30), predialysis group (n = 30), peritoneal dialysis group (n = 30), hemodialysis group, (normotensive with strict volume control, n = 30), hemodialysis group (normotensive with medication, n = 30). Plasma malondialdehyde (MDA), erythrocyte superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx) and routine biochemical parameters were studied in all patients. Hemodialysis patients with strict volume control (HDvc) had lower levels of MDA than other patient groups (p < 0.001), and CAT, SOD values had highest level other patient groups (p < 0.001). The treatment of hypertension with strict volume control in chronic renal failure patients causes less damage to the antioxidant capacity. 相似文献
7.
中国铬需求预测及资源供应安全态势分析 总被引：3，自引：0，他引：3
铬是全球公认的战略物资。随着近年来中国铬资源需求的快速上升,铬资源进口量也大幅增加,铬资源供应安全面临多重威胁。本文首先分析了中国铬资源供需现状,然后通过总结发达国家经验,预测了中国铬资源未来的需求趋势;在此基础上,本文构建了包括国内供需因素、进口因素、国际市场因素在内的3个二级指标以及现有资源保障度、二次资源回收水平等9个三级指标的铬资源供应安全指标体系,并采用层次分析法评价了中国铬资源供应安全现状,计算了中国2000年、2005年、2010年、2013年、2020年和2030年的铬资源供应安全指数。结果表明：中国铬资源供应安全指数呈现先下降后上升的变化趋势,近年来铬资源供应不安全程度持续上升,目前已处于高位,未来随着2020年铬资源需求到达顶点、二次资源回收水平的上升以及进口来源渠道的拓展,中国铬资源安全形势将逐步好转。 相似文献
8.
Mohamed Ahmed Abdelmoaty Ahmed Mohamed Bogdady Mervat Mohamed Attia Nayel Abdelhamed Zaky 《Indian journal of clinical biochemistry : IJCB》2009,24(4):398-403
Hemodynamic disorders of liver cirrhosis complicated with portal hypertension are associated with an increased angiogenesis in animal model of portal hypertension and cirrhosis which were linked to increased expression of vascular endothelial growth factor (VEGF) and nitric oxide (NO). The aim of study was to evaluate the serum concentration of VEGF and total nitric oxide (NO) in liver cirrhosis and the possible association with the degree of liver insufficiency. VEGF and NO were measured in serum of 64 patients with liver cirrhosis by ELISA and spectrophotometry respectively. The significant increase of serum VEGF was observed in liver cirrhosis compared to healthy individuals as well as serum NO (106.1 ± 66.7 vs. 41.5 ± 6 pg/mL, P < 0.05; 113.5 ± 65.8 vs. 20.8 ± 3.8 μmol/l, P< 0.001, respectively). Serum VEGF and NO showed significant associations with biochemical indices of liver function and with Child-pugh score where they were increased respectively to the degree of liver insufficiency. A significant association of raised serum NO in early stage of portal hypertension reflect its benefit in early expect of portal hypertension but, high serum VEGF in late stage may reflect its prognostic value in liver cirrhosis. 相似文献
9.
Abolfazl Nasiri Nasrin Ziamajidi Roghayeh Abbasalipourkabir Mohammad Taghi Goodarzi Massoud Saidijam Hamid Behrouj Sara Solemani Asl 《Indian journal of clinical biochemistry : IJCB》2017,32(3):329-336
One of the most important complications of diabetes is nephropathy. This study investigates the effects of aqueous garlic extract on inflammation and oxidative stress status in the kidneys of diabetic rats. Male rats were divided into four groups- control rats, diabetic rats, garlic extract-treated diabetic rats, garlic extract-treated normal rats. The glucose, urea, uric acid, and creatinine levels were measured in sera using colorimetric methods. To determine the oxidative stress condition in the kidney tissues, total antioxidant capacity (TAC), malondialdehyde (MDA), and total oxidant status (TOS) were measured using colorimetric methods. Inflammation status was evaluated by the determination of tumor necrosis factor-alpha (TNF-α) gene and protein expression using qRT-PCR and ELISA respectively, while nitric oxide (NO) level in these tissues was measured using the Griess method. Histological examination of Kidneys was carried out by H&E staining. The levels of glucose, urea, and uric acid were found to increase in the serum of diabetic rats and decrease in that of diabetic rats after treatment with garlic. Measurement of MDA, TOS, and TAC revealed oxidative stress in diabetic rats, which improved after receiving the extract. The NO and TNF-α protein levels in diabetic rats were higher than those in control rats. After treatment with garlic, the levels of TNF-α protein and NO became close to the normal levels. Histological results confirmed certain other data as well. Garlic has antioxidant properties; therefore, it can reduce oxidative stress, which plays an important role in the development of diabetic nephropathy. Reduction in oxidative stress has beneficial effects on inflammation because it leads to a decrease in the level of TNF-α. 相似文献
10.
我国城市化成本关系的实证分析 总被引：1，自引：0，他引：1
对城市化私人成本、公共成本及城市化率进行了因果关系检验,发现其关系为:私人成本支出是城市化率提高的直接动因,而城市化率提高又引起公共成本的支出增加。若政府公共成本支出不足,不会降低城市化的速度,将导致城市公共资源紧张,引起若干社会问题。 相似文献
11.
B. Talukdar S. Verma S. C. Jain M. Majumdar 《Indian journal of clinical biochemistry : IJCB》1996,11(2):129-133
We conducted a controlled study on effect of selected yoga practive in the control and management of 50 cases of essential hypertension and equal number of healthy (nonhypertensive) controls. Free radical cellular damage is considered to be the underlying common biological factor in essential hypertension. We, therefore, investigated lipid profile lipid peroxidation and Na+K+ ATPase activities of plasma membrane of subjects with essential hypertension. It was found that hypertensive subjects had an elevated lipid peroxidation and decreased Na+K+ ATPase activity in plasma membrane as compared to normotensive healthy controls, the specific yoga training protocol which was administered not only helped to decrease blood pressure but also retard the progression of ceellular damage due to free radicals. 相似文献
12.
Joya Ghosh 《Indian journal of clinical biochemistry : IJCB》2012,27(3):306-308
Nitric oxide (NO) derivative of l-arginine is an important signaling molecule that mediates a variety of essential physiological processes including vasodilation neurotransmission, and host cell defense. Many types of cells produce NO e.g., smooth muscle cell, endothelial cell, and leukocytes. Host defense functions are known for many bacterial and parasitic infections. In the present study we estimated the levels of serum NO in cases of salmonellosis and in controls. The nitric oxide was estimated by cadmium reduction method, Griess reaction. We observed that in controls the level of NO was (22 ± 2.06) μmol/l and in cases the level was (137.49 ± 29.84) μmol/l. The level of NO was significantly higher than controls (p < 0.001). The raised level of NO could be accounted for by host response to the infection. The host rapidly expresses iNOS, which in turn produces an excess amount of NO. Its cytotoxic effect is by its reactive nitrogen oxide derivative e.g., peroxynitrite. Apart from this it also has anti apoptotic functions. In future one can do follow up study of typhoid cases by bacterial culture. 相似文献
13.
Benedicta D’Souza Sulekha Sinha Poornima Manjrekar Vivian D’Souza 《Indian journal of clinical biochemistry : IJCB》2013,28(3):309-310
High ferritin levels have been found to be associated with non infectious as well as infectious causes including tuberculosis. This is one case report of 41 year old male who presented with cough with expectoration. The patient had Multi drug resistant tuberculosis (MDRTB) and type 2 diabetes mellitus. The laboratory findings showed Iron 280 μg/dl, Total iron binding capacity (TIBC) 61 μg/dl, and ferritin 92,945 ng/ml which indicates that iron is an essential nutrient for the survival of the pathogen Mycobacterium tuberculosis. 相似文献
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A. Bhise P. V. Krishnan R. Aggarwal M. Gaiha J. Bhattacharjee 《Indian journal of clinical biochemistry : IJCB》2005,20(2):4-9
The present study comprised 100 patients of essential hypertension who were screened for fasting hyperinsulinemia, which was
detected in 77% cases. Twenty such hyperinsulinemic cases were subjected to 4 weeks of dietary control phase followed by 6
weeks of omega-3 fatty acids substitution [either 0.6 g/d (group 1) or 1.2 g/d (group 2)]. The mean basal fasting plasma insulin
levels were significantly higher (p<0.001) in patients of hypertension when compared to normal controls (126.51±80.36 and
19.35±12.61 μU/ml respectively). At the end of 4 weeks of diet control only, no significant change was observed in any parameter.
After substitution of omega-3 fatty acid, a significant reduction of fasting plasma insulin levels in both group 1 (29%) and
group 2 (22.8%) was observed (p<0.001). Significant reduction of systolic and diastolic blood pressure (16.4% and 25% respectively),
serum cholesterol, triglycerides and low density lipoprotein was also noted in both groups (p<0.001), while high density lipoprotein
increased by ∼8 mg% in both groups. Thus omega-3 fatty acid substituion in low dose along-with curtailment of dietary omega-6
fatty acid may be used as an adjunctive measure in the management of essential hypertension. 相似文献
16.
Dolly Jaiswal Prashant Kumar Rai Amit Kumar Geeta Watal 《Indian journal of clinical biochemistry : IJCB》2008,23(2):167-170
The present study deals with the evaluation of glycemic profile of aqueous extract of Cajanus cajan leaves in streptozotocin induced type 2 diabetic rats. Single oral administration of graded doses of aqueous extract of Cajanus
cajan leaves showed significant increment of 14.3 % in fasting blood glucose levels of normal rats. The sub diabetic and mild diabetic
models have also shown hyperglycemic effect from the same variable doses of the extract. The dose of 1000 mg/kg showed the
maximum rise of 17.1, 71.2 and 50.7 % in Blood glucose levels of normal, sub and mild diabetic rats respectively during glucose
tolerance test. The study of leaves was taken into consideration on the basis of earlier reported hypoglycemic activity of
Cajanus cajan seeds. However the results observed were found just opposite and therefore it may be useful in controlling hypoglycemia,
occasionally caused due to excess of insulin and other hypoglycemic drugs. 相似文献
17.
Ishrat Kareem S. A. Jaweed J. S. Bardapurkar V. P. Patil 《Indian journal of clinical biochemistry : IJCB》2004,19(2):124-127
The present study was undertaken in 100 subjects, 30 diabetics without complication (group I), 40 diabetics with retinopathy
(group II) and 30 non diabetic as normal control group (group III). Blood sugar levels, magnesium, cholesterol and triglyceride
were analyzed from plasma and serum. The results were correlated with degree of diabetic control from the levels of glycosylated
hemoglobin. Serum magnesium levels in group II were found to be significantly lowered than in group I. There was also significant
difference in magnesium levels of group I and group III. We found a significant correlation between the glycosylated hemoglobin
and magnesium levels in our study.
The results also indicate that the patients with diabetic retinopathy showed significant rise in serum cholesterol and triglyceride.
Probably hypomagnesemia and increased serum cholesterol and triglyceride levels are responsible for microvascular changes
in diabetes leading to retinopathy. The purpose of this study was thus to gather information about the degree of control of
diabetes and magnesium status. 相似文献
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