共查询到19条相似文献，搜索用时 187 毫秒
1.
目的通过观察腹部手术治疗后患者肠麻痹恢复情况,评价五磨脐贴对腹部术后胃肠功能恢复的促进作用;观察腹部手术患者血清中血管活性肠肽和降钙素基因相关肽的变化及五磨脐贴对其影响,探讨五磨脐贴促进腹部手术患者胃肠功能恢复的机理。方法80例患者分为两组,治疗组采用五磨脐贴外敷神阙穴,对照组不使用任何促胃肠动力药,观察患者术后肠鸣音恢复时间及术后肛门排气时间,观察两组血管活性肠肽和降钙素基因相关肽的变化。结果术后肠鸣音恢复时间及术后肛门排气时间组间比较,五磨脐贴治疗组的时间明显短于空白对照组,差异有显著性意义(P<0.01)。治疗前,两组血管活性肠肽和降钙素基因相关肽含量无=明显差异(P>0.05);治疗后,治疗组血管活性肠肽和降钙素基因相关肽较对照组明显降低,差异有显著意义P<0.05);五磨脐贴治疗组治疗前血管活性肠肽和降钙素基因相关肽含量明显高于治疗后,差异有非常显著性意义(P<0.01)。结论五磨脐贴抑制腹部手术患者血管活性肠肽和降钙素基因相关肽的分泌,促进胃肠功能的恢复。 相似文献
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《昭通师范高等专科学校学报》2018,(5)
血管生长素(Angiogenin, ANG)主要与宿主防御功能相关,是核糖核酸酶基因(Ribonuclease A,RNASE A)超家族重要成员之一。基于基因组水平对食肉目2个超科7科14个物种开展ANG分子进化研究,采用Blast N与TBlast N的方法,共获得9条功能基因和5条假基因。功能基因平均等电点为9.52,其值明显高于RNASE A超家族其它成员,典型的RNASE A超家族序列特征在ANG中未发生改变,揭示食肉目ANG拥有原有的宿主防御功能。系统发育树显示猫型超科4个物种聚为一簇,犬型超科的海豹科与海象科形成姐妹群。 相似文献
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天麻素是天麻的主要活性成分,药理作用多样,应用广泛。近来,天麻素对神经系统的作用研究受到越来越多的关注。目前的研究结果认为天麻素具有镇痛、镇静、催眠、抗惊厥、抗癫痫、抗神经退行性疾病等神经药理作用。其作用机制尚未完全阐明,现有结果显示其神经保护机制与抑制星形胶质细胞活化、抑制降钙素基因相关肽表达、降低背根神经节的必奋性、激活苯二氮草类受体、降低脑内多巴胺与玄甲肾上腺素的含量、维持脑内氨基酸神经递质的平衡以及抑制脑内神经突触重塑等密切相关。 相似文献
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Jie DING Hui XU Xiang YIN Fu-rong ZHANG Xiao-ping PAN Yi-an GU Jun-zhu CHEN Xiao-gang GUO 《Journal of Zhejiang University. Science. B》2014,(3)
研究目的:系统评价雌激素受体α基因PvuII基因多态性与冠心病的关系。创新要点:目前关于雌激素受体α基因PvuII基因多态性(c.454-397TC)与冠心病的关系仍存在争议。因此本研究针对这一问题系统收集国内外符合纳入与排除标准的研究,通过meta分析,系统地评估雌激素受体α基因PvuII基因多态性与冠心病的关系。研究方法:针对研究问题系统检索国内外相关数据库,根据事先制定的纳入与排除标准及质量评价量表,筛选出符合标准的研究文献。利用STATA11.0和RevMan 5.2软件对纳入的21篇研究(包括9926病例和16710对照)进行定量分析。优势比(OR)值及95%置信区间(CI)用来衡量雌激素受体α基因PvuII基因多态性与冠心病的关系。重要结论:Meta分析结果提示,雌激素受体α基因ESR1 PvuII基因多态性与冠心病的关系在研究的整体人群中有重要意义。地区亚组分析显示,在亚洲人群中,雌激素受体α基因PvuII基因多态性与冠心病相关,然而这种相关性不存在于西方人群。 相似文献
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顾志良 《常熟理工学院学报》2005,19(4):66-71
肌肉生长抑制素（Myostatin）属于转化生长因子β（TGF—β）超家族中的一个新成员,是控制骨骼肌生长发育的重要细胞因子。本文综述了该基因的结构和功能的研究进展。 相似文献
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利用GenBank数据库中Nodal分子的核酸和蛋白相关信息,采用生物信息学方法分析Nodal的分子生物学特征及其剪接异构体.应用基因克隆方法克隆人Nodal基因.结果表明Nodal基因至少有四种剪接异构体,除研究较清楚的isoform 1相对完整外,其它剪接异构体信息并不完整、功能未知且表达可能有组织特异性.特别是虽然Nodal基因isoform 1的氨基酸编码序列已知,但是发现目前NCBI提供的Nodal基因mRNA参考序列并不完整.通过基因克隆发现一种新的Nodal基因剪接异构体,它可能具有TGF-β超家族的特征性结构,但功能未知.结果说明人Nodal基因可能至少存在5种剪接异构体,除isoform 1外,其它isoform具体功能还有待进一步研究. 相似文献
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《淮北师范大学学报》2015,(4)
为寻找Magnetospirillum gryphiswaldense MSR-1中与磁小体合成相关的基因,实验利用氧气浓度对MSR-1生长的影响,应用m RNA差异显示技术筛选与磁小体合成相关的c DNA片段,经测序后获得7条差异片段序列.共得到M-1,M-2,…,M-7共7条差异片段,然后进行生物信息学分析.片段M-2和片段M-3推测蛋白质均含有保守结构域Mqs R,根据Mqs R对生物膜形成有重要调节作用推测此片段可能与磁小体外膜的形成有关.其中M-4推测蛋白质具有保守结构域rpo H2,推测此片段编码的蛋白质可能是识别MSR-1中磁小体合成相关基因起始位点的酶.片段M-5推测的蛋白质具有PPK2超家族和ALDH-SF超家族,推测片段M-5编码蛋白质的功能可能是为磁小体提供能量.片段M-6,M-7编码蛋白质推测功能可能也是为MSR-1合成磁小体提供能量. 相似文献
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肌肉生长抑制素（MSTN）属于转化生长因子超家族,是主要在骨骼肌中特异性表达且功能比较专一的肌肉发育负调控因子．鱼类的MSTN基因比较复杂,具有不同的同源基因．本文综述了鱼类MSTN基因的结构、种类、时空表达特征,MSTN的作用机理及生物学功能,鱼类MSTN基因多态性研究以及MSTN基因在鱼类生产中潜在的应用前景． 相似文献
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心房肽（ＡＮＰ）是近十几年来发现的一种神经内分泌激素，在神经细胞和心房肌细胞等部位合成、储存和释放，其活性部位是一个由１７个氨基酸组成的环状结构。人的ＡＮＰ基因位于１号染色体短背上。ＡＮＰ受体广为分布，分为Ｒ１ 和Ｒ２ 两种类型。ＡＮＰ具有强大的排钠利尿、降压和其它生物学功能。 相似文献
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Xiao-fen He Jun-jun Wei Sheng-yun Shou Jian-qiao Fang Yong-liang Jiang 《Journal of Zhejiang University. Science. B》2017,18(3):239-248
Objective
To investigate the analgesic effects of electroacupuncture (EA) at 2 and 100 Hz on type 2 diabetic neuropathic pain (DNP) and on the expressions of the P2X3 receptor and calcitonin gene-related peptide (CGRP) in the dorsal root ganglion (DRG).Methods
Rat type 2 DNP was induced by a high calorie and high sugar diet fed for 7 weeks, plus a single intraperitoneal injection of streptozotocin (STZ) after 5 weeks. EA at 2 and 100 Hz was carried out once every day after 7 weeks for 7 consecutive days. Body weight, serum fasting insulin (FINS), fasting blood glucose (FBG), insulin sensitivity index (ISI), and paw withdrawal latency (PWL) were measured. The expressions of L4–L6 DRG P2X3 receptors and CGRP were assessed by immunofluorescence.Results
Type 2 DNP was successfully induced as shown by the increased body weight, FINS, and FBG, as well as the reduced ISI and PWL. Expressions of P2X3 receptors and CGRP in L4–L6 DRGs increased. EA at both 2 and 100 Hz relieved type 2 DNP, but the analgesic effect of EA was stronger at 2 Hz. P2X3 receptor expression decreased in L4–L6 DRGs following EA at 2 Hz and in L5 and L6 DRGs following EA at 100 Hz. EA at both 2 and 100 Hz down-regulated CGRP overexpression in L4–L6 DRGs.Conclusions
These findings indicate that EA at 2 Hz is a good option for the management of type 2 DNP. The EA effect may be related to its down-regulation of the overexpressions of the DRG P2X3 receptors and CGRP in this condition.12.
Liu HY Wang G Wei K Pi XT Zhu L Zheng XL Wen ZY 《Journal of Zhejiang University. Science. B》2010,11(12):937-943
In clinical practice, examination of the hemorrhagic spot (HS) remains difficult. In this paper, we describe a remote controlled
capsule (RCC) micro-system with an automated, color-based sensor to identify and localize the HS of the gastrointestinal (GI)
tract. In vitro testing of the detecting sensor demonstrated that it was capable of discriminating mimetic intestinal fluid
(MIF) with and without the hemoglobin (Hb) when the concentration of Hb in MIF was above 0.05 g/ml. Therefore, this RCC system
is able to detect the relatively accurate location of the HS in the GI tract. 相似文献
13.
Early metabolism evaluation making traditional Chinese medicine effective and safe therapeutics 总被引：1，自引：0，他引：1
Increasing attention is being paid to the scientific evaluation of traditional Chinese medicine （TCM）. As many TCMs are capable of biotransformation in the gastrointestinal tract, attention to biotransforrnation of TCM in the gastrointestinal tract may lead to discovery of the active components and active mechanisms. In this article, we review reports that host metabolic enzymes and intestinal bacteria may be responsible for the metabolism of TCM. Good understanding of the in vivo course of TCM will help us to know how to conduct metabolism evaluation of TCM by using in vitro human-derived system. This evaluation system will create new views on TCM as effective and safe therapeutic agents. 相似文献
14.
We presented a wireless endoscope system developed on the embedded Linux platform. This wireless endoscope system consists of three parts： the endoscope capsule, the portable equipment and the image workstation, which make this system wireless and portable. Hardware design of this system and software design of the portable equipment are described. In clinical use, patients swallow the endoscope capsule for gastrointestinal inspection. The portable equipment receives images of gastrointestinal tract via the radio frequency module while it sets and reads back parameters of the capsule via the low frequency module. Acquired image data can be saved as a FAT32 format file in an universal serial bus disk. Images can be processed and reviewed at an Microsoft Windows PC workstation in the next stage. The image acquired by this wireless endoscope system is quite effective with clear details of gastrointestinal tract. However, the endoscope capsule was large, making it difficult to swallow. So the printed circuit board design of endoscope capsule needs to be improved. 相似文献
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乙酰胆碱（acetylcholine．Ach）对心肌和胃肠道平滑肌的生理效应差异显著,Ach引起心肌产生负性的变时、变力、变传导反应,却使胃肠平滑肌兴奋收缩;心肌和胃肠道平滑肌分布着多种Ach受体,心肌的主要功能受体为M2,胃肠平滑肌的主要功能受体为M3。 相似文献
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文章通过临床观察奥沙利铂联合LF方案治疗大肠癌的疗效及毒副反应,治疗有效率57.14%,主要毒副反应为胃肠道反应,骨髓抑制。结果表明该治疗方案治疗大肠癌疗效肯定,耐药性良好,是一种较理想的联合化疗方案。 相似文献
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Zhi-mei Tian Xian-yong Ma Xue-fen Yang Qiu-li Fan Yun-xia Xiong Yue-qin Qiu Li Wang Xiao-lu Wen Zong-yong Jiang 《Journal of Zhejiang University. Science. B》2016,17(10):742-751
To investigate dietary protein level effects on digestive mechanisms, weaned piglets were fed for 45 d with diets containing 20%, 17%, or 14% crude protein (CP) supplemented to meet requirements for essential amino acids. This article describes the influence of dietary protein on gastrointestinal hormones and expression of an array of digestive enzymes in the gastrointestinal tract and pancreas. Results indicated that there were no significant differences in expression of enzymes involved in carbohydrate digestion, except for maltase in the duodenum. In the jejunum, amylase expression in pigs fed 20% CP was much higher than that in pigs fed other diets (P<0.05) and maltase expression in those fed 17% CP was higher than that in other treatments (P<0.05). Although there were no remarkable differences in expression of aminopeptidase in the small intestine or carboxypeptidase in the pancreas (P>0.05), there was a trend towards higher expression of various proteases in pigs fed 17% CP. The duodenal expression of enteropeptidase in diets with 14% and 17% CP was significantly higher than that with 20% CP (P<0.05), but treatment differences did not existed in jejunum (P>0.05). The expression of GPR93 as a nutrient-responsive G protein-coupled receptor in 14% and 17% CP diets was significantly higher than that in 20% CP diet in the small intestine (P<0.05). The expressions of genes for pancreatic enzymes, lipase and elastase, were significantly higher in pigs fed diets with low CP, while similar trends occurred for carboxypeptidase, chymotrypsin and amylase. Conversely, the gastric expressions of pepsinogen A and progastricsin were lower with the 17% CP diet. Differences between treatments were found in the gastric antral contents of cholecystokinin and somatostatin: both increased in pigs fed 17% CP, accompanied by decreased content of motilin, which was also seen in plasma concentrations. These patterns were not reflected in duodenal contents. In general, 17% dietary CP was beneficial to the digestion of nutrient substance in the gastrointestinal tract. 相似文献