共查询到20条相似文献，搜索用时 468 毫秒
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ADMA与动脉粥样硬化研究进展 总被引：1，自引：0，他引：1
动脉粥样硬化等多种心血管疾病,表现为血管内皮功能紊乱,并伴有非对称性二甲基精氨酸 （ADMA,内源性一氧化氮合酶抑制物）血浓度的升高,ADMA可能是一种重要的致动脉粥样硬化因子。 ADMA通过抑制一氧化氮合酶（NOS）、致炎与诱导氧化应激等机制影响内皮细胞、平滑肌细胞、单核细胞及血小板等多种细胞功能,从而促进动脉粥样硬化发生与发展。 相似文献
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谈玲芳 《孝感职业技术学院学报》2003,6(2):77-79
目前已发现数个Bcl-2基因家族成员。主要有Bcl-2、Bax等，它们调节子宫内膜细胞的凋亡，与子宫内膜增生、癌变有密切联系。 相似文献
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临床应用中的PTCA技术,由于金属支架植入后对血管壁的损伤及异物的炎性反应,可引起内膜增生而导致血管内再狭窄.为解决这一难题,采用药物涂层支架进行控制和预防.通过不同的方式对金属支架表面进行药物涂层,并对药物释放量进行比较. 相似文献
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文章以清洁级纯系雄性SD大鼠为实验模型,应用组织病理学、RT—PCR技术,研究高脂饮食诱发动脉粥样硬化过程中血管内膜细胞大电导钙激活的钾通道（large conductance Ca—activated K＋ channels,BKCa）、中电导钙激活的钾通道（Intermediate condutance Ca—activated K＋ channels,IKCa）基因表达的动态改变情况,从基因表达水平探讨高脂饮食诱发动脉粥样硬化的作用机制。同时指出,IKCa可能为动脉粥样硬化的早期启动因子,此观点有助于动脉粥样硬化的早期检测与防治。 相似文献
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支学军 《河北北方学院学报(医学版)》2006,23(2):81-82
低氧性肺动脉高压（HPH）是肺心病发病过程中的中心环节，肺动脉高压（PAH）的产生及严重程度明显影响着慢性阻塞性肺疾病和肺心病的病程及预后，因此有关PAH发病机制及治疗的研究一直是国内外研究的重点和热点，并取得了可喜的进展。低氧性肺动脉高压的病理机制较为复杂，可存在着三组相关反应即血管收缩／血管舒张、细胞有丝分裂／细胞生长抑制、血栓形成／纤维蛋白溶解之问的失平衡，引起肺血管张力增加、收缩反应增强和肺血管重构。目前所知，多种因素参与了HPH的发生发展过程，包括5-羟色胺（5-HT）、内皮素（ET）、 相似文献
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目的:近年来发现内皮抑素可以抑制组织纤维化,但是具体机制不详。本文旨在研究内皮抑素抑制纤维化的作用机制。创新点:首次阐明了内皮抑素对成纤维细胞PDGFRβ(血小板衍生生长因子受体β)/ERK(细胞外调节蛋白激酶)信号通路的影响及其与纤维化的关系。方法:体外培养人成纤维细胞,采用血小板衍生生长因子-BB(PDGF-BB)或转化生长因子-β1(TGF-β1)建立细胞纤维化模型,进一步应用内皮抑素处理,通过检测胶原及肌成纤维细胞表面标志等了解内皮抑素对细胞纤维化和表型转化的抑制作用。进而检测内皮抑素对成纤维细胞PDGFRβ/ERK信号通路的影响,并分析其可能与抗纤维化作用存在的关联。结论:内皮抑素通过调控PDGFRβ/ERK信号通路抑制瘢痕增生,是多靶点的、具有较好的抗纤维化临床应用前景的药物。 相似文献
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目的：探讨辛伐他汀对外源性制备的糖基化终末产物损伤大鼠离体胸主动脉环内皮依赖性舒张功能的影响及其机制。方法：按文献方法制备糖基化终末产物,采用外源性糖基化终末产物（AGE-BSA）孵育大鼠离体胸主动脉环90min诱导血管内皮功能的损伤,并观察辛伐他汀、超氧化物歧化酶和L-精氨酸对糖基化终末产物致的血管内皮依赖性舒张功能损害的影响。结果：外源性糖基化终末产物孵育大鼠离体胸主动脉环90min,明显抑制乙酰胆碱诱导的内皮依赖性血管舒张反应（endothelium-dependent relaxation,EDR）。但对硝普钠诱导的内皮非依赖性血管舒张反应没有影响。辛伐汀（0．05,0．1,0．2μmol／L）与AGE-BSA共同孵育血管环90min,浓度依耐性地改善AGE-BSA对血管内皮依赖性舒张功能的损害。氧自由基清除剂超氧化物歧化酶（superoxide dismutase,SOD,200U/mL）也可逆转AGE—BSA对内皮依赖性血管舒张反应的损害,而L-精氨酸（L-arginine,L-Arg,3mmol／L）却只有部分保护作用。而且,辛伐他汀也能取消SOD抑制剂二乙基二硫氨甲酸酯（diethyldithiocarbamate,DETC;10μmol／L）．诱导产生内源性氧自由基所致的血管内皮依赖性反应的抑制。结论：辛伐他汀能取消AGE-BSA对大鼠离体胸主动脉环血管内皮依赖性舒张反应的抑制。该保护作用可能与其抗氧化作用有关。 相似文献
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高血糖环境下内皮细胞的损伤 总被引：4，自引：0，他引：4
糖尿病血管并发症是糖尿病患者最常见和最严重的慢性并发症 ,如大中动脉的粥样硬化和微血管病变(糖尿病肾病、糖尿病视网膜病变、糖尿病神经病变及糖尿病脑血管功能障碍等 ) ,是预后不良及致死的主要原因。糖尿病的重要特征高糖血症在其中起重要作用。高血糖除可引起代谢障碍外 ,还可引起内皮损伤 ,增加细胞死亡 ,引发血管增生。血管内皮细胞是血管病变的关键部位 ,Ｒｏｓｓ的损伤反应学说认为 ,内皮细胞损伤是动脉粥样硬化的始动环节。糖尿病血管并发症在很大程度上正是由于高糖血症引起血管内皮细胞损伤或功能改变而形成。近年来血管内皮… 相似文献
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This paper discusses research examining the attitudes and behaviours of researching women in academia and considers the effect
of these factors on successful researching outcomes. The results of this exploratory research highlight in particular, a number
of interesting environmental influencers which contribute to enhancing successful work outcomes for academic women researchers.
Specifically, personal factors such as, marital status, partner support, age, cultural background and level of organisation
(in life) coupled with, research defined factors such as incentive for conducting the research and the existence of research
partnerships and/or groups are identified as significant performance influencers. These dimensions appear to facilitate the
level of research productivity for women academics based on key performance indicators such as journal/conference paper submissions
and successful research funding applications. The potential benefits of this exploratory research are that any correlation
between specific self-supporting attitudes or behaviours of successful women academics and effective research outcomes could
provide important clues to both emerging and continuing researchers for career development and promotion. 相似文献
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通过对山东省生物学教育硕士的求学动因、学习成效、课程设置、在学满意度、困难与困惑等方面进行调查研究发现,山东省生物学教育硕士的求学动因多样化且主导动因积极向上。因此,生物学教育硕士的培养应进一步优化课程设置与课程内容的设计,优化教学方法。 相似文献
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从教学内容设计、教师及研究生授课形式以及结合研究生具体研究课题对硕士研究生分子生物学综述式教学进行了阐述.综述式教学不仅能够让研究生全面深入地掌握分子生物学基本理论知识,熟悉分子生物学研究思路和方法,了解分子生物学领域的新进展,并且能够达到通过专业课程教学培养研究生科研能力的目标.在研究生教学过程中应用综述式教学,能逐渐培养硕士研究生的科学研究兴趣,提高研究生科研创新能力和设计能力. 相似文献
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吴喆 《岳阳职工高等专科学校学报》2013,(5):91-95
宫颈癌早期是以手术为主的综合治疗,中晚期是以放疗为主的综合治疗。尽管有多种治疗方法可供选择,具有复发高风险因素如巨块型、盆腔淋巴结转移、脉管淋巴转移等情况的宫颈癌,预后仍较差。了解评价宫颈癌预后的生物学指标,对宫颈癌患者治疗方案的选择、化疗及放疗的剂量调整等至关重要。本文从宫颈癌肿瘤内环境指标、与宫颈癌细胞生物学特性相关指标、离体标本相关指标、分子功能影像学方法四方面评价宫颈癌预后生物学指标的最新进展。 相似文献
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Research on factors that shape recruitment and retention in undergraduate science majors currently is highly fragmented and in need of an integrative research framework. Such a framework should incorporate analyses of the various levels of organization that characterize academic communities (i.e., the broad institutional level, the departmental level, and the student level), and should also provide ways to study the interactions occurring within and between these structural levels. We propose that academic communities are analogous to ecosystems, and that the research paradigms of modern community ecology can provide the necessary framework, as well as new and innovative approaches to a very complex area. This article also presents the results of a pilot study that demonstrates the promise of this approach at the student level. We administered a questionnaire based on expectancy-value theory to undergraduates enrolled in introductory biology courses. Itself an integrative approach, expectancy-value theory views achievement-related behavior as a joint function of the person's expectancy of success in the behavior and the subjective value placed on such success. Our results indicated: (a) significant gender differences in the underlying factor structures of expectations and values related to the discipline of biology, (b) expectancy-value factors significantly distinguished biology majors from nonmajors, and (c) expectancy-value factors significantly predicted students' intent to enroll in future biology courses. We explore the expectancy-value framework as an operationally integrative framework in our ecological model for studying academic communities, especially in the context of assessing the underrepresentation of women and minorities in the sciences. Future research directions as well as practical implications are also discussed. 相似文献
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苦参碱的抗肿瘤机制较为广泛,包括抑制端粒酶活性、抑制肿瘤细胞增殖、抑制肿瘤细胞转移和诱导肿瘤细胞凋亡等．近年来,对苦参碱抗肿瘤机制的研究又有了新进展,相关研究已经深入到分子和基因水平,本文对近年来苦参碱抗肿瘤作用机制研究方面取得的最新进展进行了综述,并对苦参碱抗肿瘤作用的研究方向进行了展望． 相似文献
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Cathy Buntting Richard Kevin Coll Alison Campbell 《International Journal of Science and Mathematics Education》2006,4(4):641-668
Introductory tertiary level science classes (i.e., at the university or post-compulsory school level) including those for biology face increasing diversity in intake. Previous research has indicated university level teachers assume a certain level of prior knowledge which may or may not be possessed by such students. This report focuses on the use of concept mapping in introductory biology tutorial classes. The research findings suggest that the students found the use of concept mapping enjoyable and that it can enhance meaningful learning for topics that require students to link concepts. 相似文献
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Zohar Snapir Catherine Eberbach Cindy Hmelo-Silver Jaklin Tripto 《International Journal of Science Education》2013,35(15):2092-2127
ABSTRACTScience education today has become increasingly focused on research into complex natural, social and technological systems. In this study, we examined the development of high-school biology students’ systems understanding of the human body, in a three-year longitudinal study. The development of the students’ system understanding was evaluated using the Components Mechanisms Phenomena (CMP) framework for conceptual representation. We coded and analysed the repertory grid personal constructs of 67 high-school biology students at 4 points throughout the study. Our data analysis builds on the assumption that systems understanding entails a perception of all the system categories, including structures within the system (its Components), specific processes and interactions at the macro and micro levels (Mechanisms), and the Phenomena that present the macro scale of processes and patterns within a system. Our findings suggest that as the learning process progressed, the systems understanding of our students became more advanced, moving forward within each of the major CMP categories. Moreover, there was an increase in the mechanism complexity presented by the students, manifested by more students describing mechanisms at the molecular level. Thus, the ‘mechanism’ category and the micro level are critical components that enable students to understand system-level phenomena such as homeostasis. 相似文献