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1.
Background： The purpose of this study was to describe our experiences and analyze the benefits of video-assisted thoracoscopic surgery （VATS） combined with positron emitted tomography （PET）-computed tomography （CT） in the diagnosis of patients with early （Stage 1） sarcoidosis. Methods： From 1995 to 2006, seven patients （two males, five females）, with ages ranging from 26 to 58 years, were impressed with Stage 1 sarcoidosis （mediastinal or hilar lymph nodes involvements without lung involvement） by histological examination of intrathoracic lymph nodes （LNs） and/or lung parenchyma taken＇from VATS biopsy. Three of them received PET or PET-CT evaluation. VATS was approached from the right and left side in one and six patients, respectively, according to the locations of their lesions. Results： All the VATS biopsied LNs or lung specimens were adequate for establishing diagnosis. Mediastinal LNs were taken from Groups 3, 4 in four, Group 7 in two, and Groups 5, 6 in one of them. Hilar LNs biopsies were performed in four cases. Lung biopsy was performed in all but two cases. All of them were expressed pathologically or radiologically as Stage 1 sarcoidosis. PET-CT revealed high emission signals over these affected LNs. These patients received oral steroid treatment or follow up only. All of them were followed up from 5 months to 11 years with satisfactory results. Conclusion： VATS biopsy is a minimally invasive, safe and effective procedure. It can be used as a diagnostic altermative of transbronchial lung biopsy （TBLB）, and can harvest larger and more areas of specimens than mediastinoscopy for staging patients with sarcoidosis. PET-CT can provide us more accurate information about the characteristics and localization of these lesions before biopsy. VATS combined with PET-CT can provide more accurate and earlier diagnosis of patients with unknown intrathoracic lesions, including the sarcoidosis. 相似文献
2.
目的 :了解肺结节病的临床表现的不典行性和确诊方法 ,从而加深对肺结节病的认识。方法 :回顾分析了 64例经病理证实的肺结节病患者的全部资料。结果 :根据X线征象诊断或考虑为肺结节病的确诊率为 59.3% ,经支气管镜粘膜活检的确诊率为 67.5 % ,经支气管镜肺活检(TBLB )的确诊为率 62 .5 % ,PPD试验阴性者 82 .8% ,常规行SACE检查增高者为73 .4%。结论 :因肺结节病临床表现具多样性和不典型性 ,故易导致漏诊和误诊。其诊断依赖病史、临床表现、X线、支气管镜、肺活检等多种方法 ,病理诊断是主要的确诊依据。并提倡对可疑的肺结节病患者应尽早行支气管镜粘膜活检或经TBLB检查 ,以期早日明确诊断 相似文献
3.
殷俊才 《泰州职业技术学院学报》2005,5(3):39-40
目的探讨乳腺癌的早期诊断方法。方法40岁以上、直径2cm以下乳房纤维瘤行手术切除活检；触不到肿块的乳头血性溢液行导管切除活检；40岁以上乳房囊性增生病行区段切除活检；不明原因的腋下肿大的淋巴结切除活检。结果乳房纤维瘤6．8％为早期癌；乳头血性溢液58.3％(7／12)为乳头状瘤；乳房囊性增生病10.3％为早期癌；不明原因的腋下肿大的淋巴结60．0％(3／5)为早期癌。结论对40岁以上乳房纤维瘤行切除活检；对触不到肿块的乳头溢液行导管切除活检；对40岁以上乳房囊性增生病行区段切除活检；对不明原因的腋下肿大的淋巴结切除活检可早期诊断乳腺癌。 相似文献
4.
Hwa-chan Lee Fen-fen Chen Ching-chu Lo Chung-jing Wang Wei-chun Lo Shi-ping Luh 《Journal of Zhejiang University. Science. B》2010,11(7):542-546
Cancer metastasis to the thyroid is extremely rare. The more commonly reported primary sites for metastasis to the thyroid
are the kidney, breast, lung, colon, esophagus, and uterus. Thyroid metastasis from the stomach has only been reported in
three cases. Herein, we report a 71-year-old man presenting with bilateral thyroid multinodular lesions. Bilateral near-total
thyroidectomy was performed due to airway compression with related symptoms. Wedge resection of a suspicious pulmonary nodule,
detected on CT, was performed for diagnosis. Polypoid lesions in the stomach were examined by trans-scopic biopsy. Poorly
differentiated adenocarcinomas with the same histological profiles were noted at these three sites. The immunohistochemical
staining for thyroglobulin of these specimens was negative. We conclude that a new thyroid mass appearing in a patient with
present or prior malignancies should raise the concern of metastatic disease. 相似文献
5.
Coccidioidomycosis is an endemic disease of the Western hemisphere. The cases in non-endemic areas are mostly imported. Determining
a history of exposure is critical for performing the diagnosis of coccidioidomycosis, especially for cases occurring in a
non-endemic area. In this study, a 71-year-old Chinese male presented to our hospital with chronic cough and malaise, and
was found to have a mass in the middle lobe of right lung. He had been visiting Arizona, USA for four months before admission.
Pulmonary coccidioidomycosis was confirmed by the results of histopathological examination after lobectomy. Typical microscopic
features of Coccidioides are definitely diagnostic, but need be differentiated from other budding yeast infection or carcinoma histopathologically. 相似文献
6.
目的 :为探讨C -erbB - 2蛋白在胃癌、大肠癌和乳腺癌中表达的异同和意义。方法 :取胃癌 114例、大肠癌 10 4例和乳腺癌 10 6例 ,石蜡切片 ,SP免疫组织化学染色。结果 :C-erbB - 2在胃癌、大肠癌和乳腺癌中的阳性率分别为 71.9%、5 7.7%和 5 4 .7%。C -erbB - 2在胃癌和大肠癌中的表达与患者年龄有关 ;C -erbB - 2表达与大肠癌分化程度及乳癌恶性程度有关。结论 :C -erbB - 2高表达是大肠癌、乳癌恶性度高 ,预后不良的指标 相似文献
7.
紫杉醇的药理与临床研究进展 总被引：1，自引：0，他引：1
扈志洪 《重庆第二师范学院学报》2005,18(6):46-49
紫杉醇是近年来用于癌症治疗的一种天然药物,本文综述了紫杉醇的药理作用及临床用于治疗卵巢癌、小细胞肺癌、乳腺癌和的近况,介绍了紫杉醇对其它癌症包括头颈部癌、宫颈癌、食道癌等的疗效研究及神经系统、中性粒细胞减少、过敏等不良反应,展望了紫杉醇的发展前景. 相似文献
8.
目的：通过对乳腺癌原代细胞培养。检测化疗药物对癌细胞的抑制率。探讨乳腺癌不同组织学类型、年龄及淋巴结转移情况对化疗药物的敏感性。方法：收集109例手术切除新鲜乳腺癌标本．进行原代细胞培养。采用四甲基偶氮唑盐（MTT）法检测癌细胞对三组抗癌药物的敏感性。结果：乳腺癌的敏感率由高到低依次为CAF（33．0％）、TA（31．2％）和CMF（26．6％）。无论年龄、组织学类型及是否有淋巴结转移各组间比较其敏感性均无显著差异（P〉0．05）。结论：1．MTT法对乳腺癌治疗时选择化疗药物具有重要价值；2．乳腺癌细胞对CAF、TA、CMF敏感。 相似文献
9.
目的探讨肺和食道鳞状细胞癌中P27基因蛋白的表达状况.方法收集手术切除鳞癌标本63例,10%中性甲醛固定,石蜡切片,厚度5μm.超敏型S-P免疫组织化学染色.结果P27在鳞状细胞癌中总阳性率39.68%,在肺和食道中阳性率分别为36.00%和42.15%.在高、中分化组阳性率为36.00%,低分化组阳性率为53.85%.结论鳞癌组织中P27阳性表达与分化程度及是否转移的相关性有深入研究的必要. 相似文献
10.
黄建军 《邵阳学院学报(社会科学版)》2004,3(2):58-60
康熙是中国历史上为数不多的英明君主之一。他一生积极有为、奋发进取，文治武功，彪炳史册，其政事之暇留下的一千多首诗歌就是这种精神最好的注解。康熙的诗歌无论是关于靖国安邦、关心民瘼、善始善终，还是关于接受新事物、反对神仙方士等，都体现了一种积极的生活态度，其终极目的是为实现一生孜孜以求的太平盛世理想。 相似文献
11.
目的 :探讨张家口地区乳腺癌的发病规律。方法 :对我科 2 0 0 1～ 2 0 0 2年收集的 10 6例乳腺癌进行回顾性分析。结果 :36～ 5 5岁者占 70 %以上 ,2 6岁以下和 6 6岁以上患者极少 ;浸润性导管占 75 .4 7% ,淋巴结总转移率为 4 0 .6 %。结论 :乳腺肿物早就诊对乳腺癌的早期诊断与预后有重要的意义。 相似文献
12.
Li-duan Zheng Xiu-ping Yang Hua-xiong Pan Xiu Nie Jun He Qing Lv Qiang-song Tong 《Journal of Zhejiang University. Science. B》2009,10(3):237-241
Gastric carcinoma with osteoclast-like giant cells (OGCs) is an extremely rare tumor. So far, only six cases have been reported in the literature. Here we report an additional case of this tumor in a Chinese 78-year-old man presented with abdominal pain, vomiting, and hematemesis. Physical examination and gastroscopy revealed a tumor in the gastric antrum. The biopsy and pathological findings indicated a gastric adenocarcinoma with OGCs, which were present in both the tumor and the metastatic lymph nodes. Further immunohistochemical staining indicated that OGCs were reactive with CD68, CD45, and vimentin protein, but not with pancytokeratin, carcinoembryonic antigen, or epithelial membrane antigen, suggesting the monocytic/histiocytic derivation of these OGCs. In situ hybridization for Epstein-Barr virus showed no nuclear positivity in either adenoearcinoma or OGCs. Postoperative follow-up showed that the patient had survived for at least 6 months without recurrence. Further investiga-tion is warranted to clearly define the prognostic significance of OGCs in gastric carcinoma. 相似文献
13.
目的:研究热休克蛋白27(Heat Shock Protein27)在乳腺癌中的表达.方法:采用免疫组化方法检测48例乳腺癌组织中的HSP27.结果:HSP27在乳腺癌中阳性表达率为54.17%(26/48).在非浸润性癌和浸润性癌中阳性表达率为75.00%(3/4)和52.27%(23/44).HSP27阳性表达在非浸润性癌和浸润性癌中无明显差别(P＞0.05).HSP27阳性表达与有无淋巴结转移无关(P＞0.05).结论:在乳腺癌中HSP27有较高表达,检测乳腺癌中HSP27对化疗有指导作用. 相似文献
14.
To study sensitivity to radial location of an odor source, 20 human newborns, ranging from 16 to 130 hours of age, were presented with a small amount of ammonium hydroxide. The odor source was placed near the nose slightly to the left or right of midline, with its position randomized over repeated trails. Direction of headturn with respect to the odor location and diffuse motor activity were scored from the videotape recordings of the newborns' behavior. It was found that as a group, the newborns turned away from the odor source more frequently than they turned toward it. The tendency to turn away from the odor was stronger in infants who displayed less motor activity after the response. Newborns also exhibited a right bias in the direction of the head movements. It is concluded that a spatially appropriate avoidance response is present in the neonate and that the newborn is innately sensitive to the radial location of an odor. 相似文献
15.
慕博华 《泰州职业技术学院学报》2002,2(3):46-49
目的 探讨c erbB 2、p53和nm2 3蛋白在乳腺癌组织中的表达与乳腺癌临床病理参数、雌激素受体 (ER)、孕激素受体 (PR)的关系。方法 应用免疫组化ABC法对 5 5例乳腺癌组织中的c erbB 2、p53和nm2 3蛋白表达进行检测。结果 5 5例乳腺癌中c erbB 2、p53及nm2 3的阳性率分别为 49 1 % (2 7/5 5 )、47 3 % (2 6 /5 5 )和 49 1 % (2 7/5 5 ) ,c erbB 2和p53蛋白在乳腺癌中的阳性率与肿瘤病理分级及淋巴结转移有显著意义 (P <0 0 5 ) ,与雌孕激素受体状况呈负相关 (P <0 0 1 )。nm2 3蛋白在乳腺癌中的阳性率与肿瘤病理分级、淋巴结转移有密切的关系 (p <0 0 5 ) ,与雌孕激素受体状呈正相关 (p <0 0 1 )。 70 9% (3 9/5 5 )肿瘤有上述蛋白的异常表达 ,其中 49 1 % (2 7/5 5 )的肿瘤同时有多个蛋白异常表达。结论 肿瘤的多因素分析比单因素分析更有价值 ,癌基因c erbB 2、nm2 3和抑癌基因p53蛋白的表达异常及协同作用在乳腺癌的发生发展中起重要使用 相似文献
16.
Primary mammary tuberculosis is a rare entity that usually occurs in female of reproductive age. Herein three such patients including two males with ages over 80 years, who underwent surgical resection, are reported. Fine needle biopsy failed to achieve specific diagnosis before surgical operation. All of their conditions got satisfactory improvement and anti-tuberculosis chemotherapy was administered postoperatively. Previous literature related to the epidemiology, diagnosis and treatment for mammary tuberculosis will be also reviewed. Mammary tuberculosis is usually related to breast feeding women and is extremely rare in aged man. The possible mechanisms resulting in this disease in our three patients, including direct extension, reactivation, or transmitted by staffs or peers of the nursing home, would also be discussed. 相似文献
17.
Primary leiomyosarcoma of the nipple-areola complex is extremely rare. Less than ten such cases have been reported in English literature so far. Herein we describe a 52-year-old female presenting with a 1.5 cm× 1.1 cm×0.7 cm nodular lesion over her left nipple, and leiomyosarcoma was proved by pathological examination of the excised specimen. Positron emitted tomogram (PET) revealed no abnormal signal other than the primary site. Microscopically, this poorly circumscribed tumor was composed of interlacing bundles of smooth muscle cells with bizarre and pleomorphic nuclei, as well as prominent nucleoli. Its mitotic count was up to 7 mitoses per 10 high power fields (HPF). Immunohistochemical study of tumor cells revealed positive stain for α-smooth muscle actin and vimentin; and negative for cytokeratin, CD34 and S-100. Left simple mastectomy was undertaken and no residual mass lesion was noted on the resected specimen. Related literatures about the diagnosis and treatment for breast leiomyosarcoma will be presented here. 相似文献
18.
为探讨癌胚抗原(CEA)和核仁组成区蛋白(AgNOR)在胃粘膜活检中对良、恶性病变的诊断意义,我们取105例标本进行观察。结果表明:CEA和AgNOR计数在单纯性胃炎、肠上皮化生、异型增生和胃癌中表达有关系,其阳性率和计数依次增高。CEA、AgNOR表达有显著性差异。因此,CEA、AgNOR对癌和癌前病变的诊断和治疗具有一定参考意义。 相似文献
19.
Åke Grönlund Matilda Wiklund Rickard Böö 《Education and Information Technologies》2018,23(3):1359-1375
Collaborative digital textbooks – comprehensive materials covering entire curriculums – are developing from being books in pdf format to becoming collaborative digital environments where teachers and students can communicate, engage in feedback and discussions, share and manipulate materials, test knowledge, and monitor results. This study investigates how these digital environments are used in school practice: How are the collaborative tools used to improve learning? Thirteen seventh- and eighth-grade classes, 370 students and 30 teachers in five Swedish secondary schools, were investigated over 1,5 years by means of questionnaires, classroom observations and interviews with teachers and students. Here, questionnaire results are presented, while observations and interviews serve to provide contextual insights. Collaborative tools were very little used; often teachers and students were not even aware of their existence. Most use was individual, students were left alone with the digital material. Students read or listened to the text and did not actively engage in learning by e.g. making notes or marking text. Most teachers did not use the material actively to help students understand and learn, most did not even check student results on automated tests. We conclude that the teachers have not incorporated the new, collaborative design of the digital textbook into their thinking regarding tools for teaching and learning and still regard it as a static book. This suggests that making full use of digital tools requires new ways of thinking of teaching, and that it takes more than providing digital tools to achieve this end. 相似文献
20.
乳腺外科是一门专业性和社会实践性很强的学科,并且对学生医学知识有很高要求。以往学生在传统乳腺外科学习中因为学科枯燥无味而提不起兴趣,而在乳腺外科诊治教学中融入多媒体可将枯燥的医学知识转化为形象生动的动画和音乐,从而提高学生的学习兴趣。本文主要对多媒体在乳腺外科诊治教学中进行探究。 相似文献