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环丙沙星在鳗鲡组织中残留的消除规律 总被引：7，自引：0，他引：7
在26～28℃及18～22℃水温下，以每千克体重给予50mg环丙沙星的比例对鳗鲡(Anguilla japonica)进行灌胃给药，然后采用高效液相色谱技术，分别于给药后的第4、5、6、7、9、15及21天测定环丙沙星在鳗鲡的血液、肌肉、胆汁和肾脏组织中的含量变化规律．结果显示，环丙沙星在鳗鲡体内的消除速度与水温有密切关系．在26～28℃水温下，肌肉、血液、胆汁和肾脏中的环丙沙星残留分别在第6、第7和第9天消除；而在18～22℃水温下，除肾脏中环丙沙星残留于第15天消除外，其余三种组织中环丙沙星残留的消除时间均延长至21天，表明水温对鳗鲡体内的药物代谢有明显的影响，环丙沙星残留的消除速度随水温降低而减慢．从食品安全角度来分析，在26～28℃水温下用药的鳗鲡，其上市前环丙沙星的停药期应不少于9天，而在18～22℃水温下用药的鳗鲡，其停药期应不少于21天．本研究结果为鱼类食品安全标准的制定提供了科学依据． 相似文献
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东北地区8种毒蘑菇菌株生物学特性的研究 总被引：1，自引：0，他引：1
采用植物病理学及菌物学的研究方法对8个毒蘑菇菌株的生物学特性进行研究,结果表明：（1）白霜伞、绒白乳菇、厚环鹅膏、珊瑚菌、冠状环柄菇、鳞柄白鹅膏6菌株菌丝生长的最适温度为25℃,细鳞环柄菇和鹅膏菌2菌株菌丝生长的最适温度为20℃。（2）各菌株生长最适碳源,除珊瑚菌为麦芽糖,冠状环柄菇为木糖外,其它6菌株均为葡萄糖。（3）除白霜杯伞在无氮条件下生长最好外,其他7菌株生长最佳氮源均为蛋白胨。（4）各菌株生长最适pH值：鹅膏菌、厚环鹅膏、细鳞环柄菇、鳞柄白鹅膏、珊瑚菌为6．0。绒白乳菇和冠状环柄菇为7．0,白霜杯伞为7．5,均属于喜稍偏碱出坏境的菌株。 相似文献
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己酸乙酯酯化酶产生菌的自然选育及其酶学特性的初步研究 总被引：1，自引：0，他引：1
通过对窖泥、大曲、米曲、黑曲及红曲中微生物的分离、筛选，获得两株己酸乙酯合成能力较强的菌株，经初步鉴定，都归于曲霉属。两菌株均在３０℃、ｐＨ为５的麸皮培养基中培养６０ｈ后产酶最高；Ｍｍ－４菌株的酯化酶在适宜条件下（２％乙醇和０．２５％的己酸作底物，ｐＨ为４．０，３０℃）酶活力可达２２０ｕ／ｇ。 相似文献
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目的:本文建立了氟哌酸滴耳液的处方及制备方法,并对其质量方法进行了研究。方法:该滴耳液主要由氟哌酸、醋酸地塞米松、甘油和乙醇混合制成,同时采高效液相色谱法来对滴耳液中的氟哌酸含量进行测定。结果:氟哌酸在浓度1-6μg/ml的范围内与峰面积呈现出良好的线性关系,平均回收率为99.98%,RSD=0.43%(n=5)。结论:本实验设计的处方合理,制备工艺简单,含量测定方法准确、可靠,能够用于氟哌酸滴耳液的质量研究。 相似文献
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为了制备抗环丙沙星单克隆抗体,首先采用碳二亚胺法合成了环丙沙星与载体蛋白偶联的免疫抗原和包被抗原,免疫BALB／c小鼠,取效价最高的小鼠脾细胞与骨髓瘤细胞SP2／0融合,HAT培养基筛选,有限稀释法克隆化,获得1株稳定分泌抗环丙沙星单克隆抗体的杂交瘤细胞株。检测结果显示,杂交瘤细胞染色体数目平均102条,培养上清的效价为1：1．28×10^3,单抗腹水效价达1：1．024×10^6,IC50为68．31ng／mL,属于IgM型,轻链kappa,CI—ELISA法显示单抗对环丙沙星有高度的选择性,提示获得的单抗可望用于环丙沙星残留物的免疫化学检测。 相似文献
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采用常规药物治疗耐药菌株伤寒的疗效令人失望.61例用氯霉素治疗,34例以氨苄青霉素治疗.临床无效率氯霉素组为47.6％,氨苄青露素组为23.5％.23例采用庆大霉素治疗,其临床疗效显示缓慢。在由耐药菌株引起的伤寒之治疗中,研究了非常规药物的疗效:51例患者采用硫酸小诺霉素治疗,平均退热时问需9.66±3.03天,显效率仅10％.其它如磷霉素钠、丁胺卡那霉素、氟哌酸和氟嗪酸等亦各存在不足之处.作者认为,具有协同作用的抗菌药物的联合用药,是治疗多重耐药株伤寒的最佳方法.近4年来,选用氟哌酸联合丁胺卡那霉素治疗重症伤寒,疗效满意,使伤寒的病死率显著地降低. 相似文献
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Marjorie Armstrong-Stassen Margaret Landstrom Ramona Lumpkin 《The Information Society》1998,14(2):153-164
This study examined how students who had no prior experience with videoconferencing would react to the use of videoconferencing as an instructional medium. Students enrolled in seven different courses completed a questionnaire at the beginning of the semester and again at the end of the semester. Students at the origination and remote sites did not differ in their reactions toward videoconferencing but there was a significant difference for gender. Women reacted less favorably to videoconferencing. Compared to the beginning of the semester, students reported significantly less positive attitudes toward taking a course through videoconferencing at the end of the semester. There were no significant differences in students' attitudes toward videoconferencing across courses at the beginning of the semester but there were significant differences across the courses at the end of the semester. The results suggest the need for better preparation for both students and instructors. 相似文献
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A joint study by Prof. ZHANG Zhibin from the CAS Institute of Zoology his co-workers from Norway US Swiss have indicated that historical outbreaks of migratory locusts in China were associated with cold spells suggesting that China's projected climate warming could decrease the pest's numbers. The study was published in Proceedings of the National Academy of Sciences on September .…… 《中国科学院院刊(英文版)》2008,22(1):6-7
Ajoint study by Prof. ZHANG Zhibin from the CAS Institute of Zoology and his co-workers from Norway, US and Swiss have indicated that historical outbreaks of migratory locusts in China were associated with cold spells, suggesting that China＇s projected climate warming could decrease the pest＇s numbers. The study was published in Proceedings of theNational Academy of Sciences on 17 September, 2007. 相似文献
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Caroline Haythornthwaite 《The Information Society》2001,17(3):211-226
A computer-mediated group is a complex entity whose members exchange many types of information via multiple means of communication in pursuit of goals specific to their environment. Over time, they coordinate technical features of media with locally enacted use to achieve a viable working arrangement. To explore this complex interaction, a case study is presented of the social networks of interactions and media use among members of a class of computer-supported distance learners. Results show how group structures associated with project teams dominated who communicated with whom, about what, and via which media over the term, and how media came to occupy their own communication niches: Webboard for diffuse class-wide communication; Internet Relay Chat more to named others but still for general communication across the class; and e-mail primarily for intrateam communication. Face-to-face interaction, occurring only during a short on-campus session, appears to have had a catalytic effect on social and emotional exchanges. Results suggest the need to structure exchanges to balance class-wide sharing of ideas with subgroup interactions that facilitate project completion, and to provide media that support these two modes of interaction. 相似文献
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Electronic data interchange (EDI) provides means for interorganizational communication, creates network externalities, requires an advanced information technology (IT) infrastructure, and relies on standards. In the diffusion of such innovations, institutional involvement is imperative. Such institutions contain governmental agencies, national and global standardization organizations, local government, and nonprofit private organizations like industry associations. The last type of organizations we call intermediating institutions. They intermediate or coordinate ("inscribe") the activities of a group of would-be adopters. Unfortunately, little is known of how these organizations shape the EDI diffusion trajectory. In this article we examine one specific type of intermediating organizations?industry associations?and how they advanced the EDI diffusion process in the grocery sectors of Hong Kong, Denmark and Finland. We identify six institutional measures, placed into a matrix formed by the mode of involvement (influence vs. regulation) and the type of diffusion force (supply push vs. demand pull), that can be mobilized to further the EDI diffusion. Industry associations were found to be active users of all these measures to varying degrees. Their role was critical especially in knowledge building, knowledge deployment, and standard setting. Furthermore, institutional involvement varied due to policy and cultural contingencies and power dependencies. 相似文献
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Puay Tang 《The Information Society》1998,14(1):19-31
The increasing prospects of digital piracy has prompted the perceived need by electronic publishers to adopt technical systems of protection, and governments to reform their copyright laws. This article is a preliminary study of the management of intellectual property by electronic publishers, defined as those involved in the production of online databases, and CD-ROMs. It focuses on three main issues: (1) how electronic publishers view the increasing threat of piracy; (2) the methods of protection employed to protect intellectual property in digital format; and (3) the importance of technological protection of intellectual property in electronic publications. The analysis is based on a sample of 23 UK electronic publishers. The interviews revealed an interesting assortment of protection methods and did not show that technological protection was a preferred way. Instead, the means of protection, in addition to copyright law, comprised niche markets, pricing, trust, bad publicity, and nontechnical and technical means. 相似文献
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Milton Mueller 《The Information Society》2001,17(3):151-163
Long-standing conflict between domain name registrants and trademark holders prompted the Internet Corporation for Assigned Names and Numbers (ICANN) to create a global, mandatory arbitration procedure known as the Uniform Dispute Resolution Policy (UDRP). The UDRP has been used in 2166 cases involving 3938 domain names as of 1 November 2000. The policy gives the initiator of a complaint, generally a trademark holder, the right to choose which ICANN-accredited dispute resolution service provider (RSP) will handle the case. During the preparation of the UDRP,some feared that complainant selection would lead to "forum shopping" that might bias the results. This article performs a statistical assessment of the forum-shopping thesis and finds support for it. There are statistically significant differences in the various RSPs' propensity to take away names from defendants; there are also major differences in the number of cases brought to each RSP. RSPs who take away names have the larger share of cases. The study examines other variables that might explain differences in market share, such as price, the plaintiff's nationality, or the time taken to decide a case. It finds that nationality and time also are correlated with market share. The study concludes that shopping for a favorable outcome is an important factor in the UDRP. 相似文献
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Prof. Raymond C.K. Chen a neuropsychologist with the CAS Institute of Psychology has made novel progress in his studies of schizophrenia. His work has been reported by a recent issue of Behavioural Neurology.…… 《中国科学院院刊(英文版)》2008,22(1):15-15
Prof. Raymond C.K. Chen, a neuropsychologist with the CAS Institute of Psychology, has made novel progress in his studies of schizophrenia. His work has been reported by a recent issue of Behavioural Neurology. 相似文献
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《中国科学院院刊(英文版)》2014,(3)
<正>In Xishuangbanna,one of China’s most biodiverse regions,landscape has changed dramatically during the past three decades due to the conversion of tropical rainforest to rubber plantations.In steep areas,terraces are often constructed before planting rubber trees,which causes two important changes in the soil:the destabilization of soil in the bench terraces and the increased vulnerability of unvegetated riser faces to erosion.Few studies have documented the nature and intensity of erosion on bench terraces.Prof.LIU Wenjie and his colleagues from the Xishuangbanna Tropical Botanical Garden(XTBG)conducted a study in Menglun County(21°5′39″N,101°15′55″E),Xishuangbanna to evaluate the influence 相似文献
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Chinese Scientists Use Earth Observation Technologies to Study and Protect Wild Camels 总被引：1，自引：0，他引：1
《中国科学院院刊(英文版)》2014,(3):267-268
<正>Chinese scientists plan to apply Earth Observation technologies to protect the critically endangered wild camels(Camelus ferus).With the help of remote sensing,satellite positioning,geographical information system and wireless sensors networks,they will be able to access the distribution and population of the wild camels and protect their habitats.The project will be carried out by the International Research Center for Wild Camel Conservation,which was jointly established earlier this year by the Institute of Remote Sensing and Digital Earth(RADI)of the Chinese 相似文献
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WANG Sijia 《中国科学院院刊(英文版)》2014,(2):192-194
<正>The Paul Gerson Unna Research Group on Dermatogenomics was founded in October 2012 at the Partner Institute for Computational Biology.The ultimate goal of the group is to understand the biology of skin and skin appendages. 相似文献