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目的:分析、总结内镜粘膜下剥离术应用到治疗广基结直肠息肉的临床价值。方法:选择自2016年1月—2016年12月在我院进行治疗的患有广基结直肠息肉的患者36例为本次研究对象,分析、总结患者应用内镜粘膜下剥离术(ESD)治疗广基结直肠息肉的的效果及安全性。结果:所有患者均完整剥离病灶,手术平均时间为(55±4)min。术中所有患者的手术创面均有少量出血,应用金属夹夹闭的方法止血;有2例患者出现延迟性出血,行氩气刀电凝止血;穿孔1例,行腹腔镜下穿孔修补术后恢复良好。术后病理显示,管状腺瘤6例、绒毛状腺瘤10例、管状绒毛状腺瘤8例、增生性息肉6例、类癌6例。结论:ESD具有创伤小、费用低、术后恢复快、住院时间短的优点,值得临床推广应用。 相似文献
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目的:分析、总结内镜粘膜下剥离术应用到治疗广基结直肠息肉的临床价值。方法:选择自2016年1月—2016年12月在我院进行治疗的患有广基结直肠息肉的患者36例为本次研究对象,分析、总结患者应用内镜粘膜下剥离术(ESD)治疗广基结直肠息肉的的效果及安全性。结果:所有患者均完整剥离病灶,手术平均时间为(55±4)min。术中所有患者的手术创面均有少量出血,应用金属夹夹闭的方法止血;有2例患者出现延迟性出血,行氩气刀电凝止血;穿孔1例,行腹腔镜下穿孔修补术后恢复良好。术后病理显示,管状腺瘤6例、绒毛状腺瘤10例、管状绒毛状腺瘤8例、增生性息肉6例、类癌6例。结论:ESD具有创伤小、费用低、术后恢复快、住院时间短的优点,值得临床推广应用。 相似文献
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鳖甲粉对裸鼠载人肠癌治疗作用的初步研究 总被引：4，自引：0，他引：4
用鳖甲粉对裸鼠载人肠癌进行实验性治疗.在给裸鼠接种人肠癌细胞前2周开始按每天16mg/只的剂量混入饲料经口投与,接种35d后肿瘤体积变化与对照组相比差异有显著性(P<0.05),抑瘤率达92.15％,与饮用5 Fu的阳性对照组比较差异无显著性(P>0.05).来发现鳖甲粉对小鼠产生明显毒性.实验前后白细胞计数与对照组比较差异无显著性. 相似文献
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血管紧张素转化酶基因I/D多态性与高血压脑梗塞发病的相关性 总被引：2，自引：0，他引：2
采用PCR方法分别检测82例高血压合并脑梗塞患者(BI)、67例单纯高血压患者(EH)和95例健康对照者(C)的血管紧张素转化酶(ACE)基因I/D多态性类型,并分析ACE基因I/D多态性分布与高血压合并脑梗塞发病的相关性.结果显示,BI组ACE基因的D/D基因型频率和D等位基因频率(分别为0.341和0.524)显著高于C组(分别为0.200和0.374,P<0.05)和EH组(分别为0.179和0.358,P<0.05),而EH组和C组ACE基因的D/D基因型频率和D等位基因频率无显著性差异.该研究结果表明,ACE基因的D/D基因型可能是高血压合并脑梗塞发病的独立危险因素. 相似文献
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主动脉内气囊反搏的抗凝问题 总被引：2，自引：0，他引：2
目的 研究主动脉内气囊反搏(IABP)是否需要常规抗凝.方法 连续选择IABP病人153例,随机分组进入抗凝组(A组)71例,非抗凝组(B组)82例.抗凝组静脉给予肝素针维持aPTT于50～70s.非抗凝组无肝素针静脉维持.检测二组即刻,24h,48h以及IABP拔除后24h血小板计数,D 二聚体,纤溶酶原活化剂抑制物 1(PAI 1)和纤维蛋白降解产物(FDP)水平.观察IABP引起的肢体缺血或肢体出血等并发症、以及IABP表面的血栓情况.结果 抗凝组和非抗凝组的血小板计数和PAI 1水平于24h和48h均较本身的基础值显著下降(P<0.05).抗凝组和非抗凝组的D 二聚体和FDP水平于24h和48h均较本身的基础值显著升高(P<0.05).但二组间各个时段血小板计数,D 二聚体,PAI 1和FDP水平的比较均无显著性差异.抗凝组3例,非抗凝组2例发生一般肢体缺血.抗凝组2例大出血,8例一般出血;非抗凝组2例一般出血(P<0.05).IABP表面血栓二组均无发生.结论 IABP不需常规抗凝,抗凝不能预防IABP引起的肢体缺血.选择适当的导管经路和早期发现是预防并发症的关键. 相似文献
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为了研究用全价混合饲料(TMR)对延边黄牛瘤胃环境中代谢的影响.以健康、生长状况相近的2组延边黄牛进行对比.结果:试验组和对照组瘤胃内的PH值平均分别为6.01和6.20,无显著性差异(P＞0.05),饲喂后8小时,PH值分别为5.3和,5.73,差异不显著(P＞0.05),其它各时间点都表现出显著差异(P＜0.05);瘤胃内NH3-N浓度的平均值分别为12.05mg/100ml和6.52mg/100ml,差异显著(P＜0.05).瘤胃内的总挥发脂肪酸浓度、乙酸、丙酸、丁酸的浓度的平均值差异不显著(P＞0.05),但是乙酸/丙酸平均值分别为3.31和3.03,差异显著(P＜0.05),而且比值都在正常的范围之内,都可以维持乳脂的正常合成. 相似文献
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目的 研究血管内皮生长因子(VEGF)在输卵管妊娠的种植部位、非种植部位及分泌中期正常壶腹部输卵管的表达.方法 收集输卵管妊娠的种植部位、非种植部位标本各30例,以及分泌中期正常壶腹部输卵管标本17例.采用电化学发光法检测术前血β-HCG及免疫组织化学二步法测定各组标本中VEGF的表达,根据阳性率和表达强度进行组织化学评分和相关性分析.结果 (1)种植部位输卵管粘膜上皮细胞VEGF的表达显著高于非种植部位,差异有统计学意义(P＜0.05);(2)种植部位输卵管粘膜上皮细胞VEGF的表达显著高于正常分泌期组,差异有统计学意义(P＜0.05);(3)非种植部位组与正常分泌期组之间VEGF表达差异无统计学意义(P＜0.05);(4)输卵管妊娠活胎病例中种植部位、非种植部位的VEGF表达均与血β-HCG呈统计学正相关(均P＜0.05).结论 VEGF可能参与输卵管妊娠时胚泡植入和胎盘血管网形成. 相似文献
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目的:探讨重组生物酵母乙肝疫苗不同免疫程式的免疫效果.对1620名人群进行酵母乙肝疫苗免疫接种,通过不同免疫时间、性别与年龄来反应其检测抗-HBs阳性情况.结果:1620名观察对象经过检测后,抗-HBs阳性人数为790名,检出率为48.8%,其中首次接种后第1个月、3个月和6个月的抗-HBs阳转率分别为20.0%、45.5%和94.7%,三个时间段前后差异都有统计学意义(P<0.05).不同免疫后时间段的女性抗-HBs阳性率都明显高于男性(P<0.05).不同年龄之间的抗-HBs阳转率比较无显著性差异(P>0.05).结论:酵母重组乙肝疫苗对青年人群具有良好的近期免疫效果,值得推广使用. 相似文献
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目的—将曲马多用于剖宫产术后的硬膜外自控镇痛(patientcontrolledepiduralanalgesia,PCEA),观察曲马多的镇痛效果及对产妇的产后恢复的影响。论证曲马多替代芬太尼用于剖宫产术后PCEA的可行性。方法—选择90例ASAI—Ⅱ级足月产妇,在硬膜外麻醉下施行剖宫产手术。术毕随机分为三组:非PCEA组(Ⅰ组),用芬太尼的PCEA(Ⅱ组),用曲马多的PCEA组(Ⅲ组)。Ⅰ组术毕拔除硬膜外导管回病房用传统的肌注哌替啶镇痛;Ⅱ组:0.15%罗比卡因 芬太尼2ug/ml 氟哌利多0.05mg/ml;Ⅲ组:0.15%罗比卡因 曲马多2mg/ml 氟哌利多0.05mg/ml。两组设置都为负荷量5ml,持续量为2ml/h,PCA为1ml/次,锁定时间为15分钟。记录术后24h、48h两时间点疼痛视觉模拟评分(VAS,0—10分),子宫高度,泌乳量。记录满意视觉模拟评分(VCS,0分为不满意,10分为最满意),初乳时间,肠蠕动恢复时间,PCA次数及病人主观不适。结果Ⅱ、Ⅲ组与Ⅰ组镇痛效果有显著性差异(P<0.05),Ⅱ组与Ⅲ组镇痛效果无差异(P>0.05);Ⅱ、Ⅲ组与Ⅰ组在满意视觉模拟评分、初乳时间、24h泌乳量、肠蠕动恢复时间等四项的比较,Ⅱ、Ⅲ组明显优于Ⅰ组,均有显著性差异(P<0.05)。Ⅱ组的嗜睡发生率为4例(13.3%),Ⅲ组且未发现,两者有显著性差异(P<0.05)。而48h泌乳量,三组无明显性差异(P>0.05);Ⅱ、 相似文献
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通过2006～2010年《中国科技期刊引证报告(核心版)》对我国2006～2010年48种外科学类期刊自引率进行分析,结果显示2006～2010年48种外科学类期刊自引率[用中位数(最小值～最大值)表示]分别为0.06(0.01 ～0.49),0.05(0.01 ～0.44),0.065(0.01 ～0.43),0.06(0.02 ～0.42),0.06(0.02 ～0.39),各年度自引率无显著性差异(x2=1.367,P=0.850).以自引率≥0.2为过度自引,2006～ 2010年过度自引的期刊分别为4种(8.3％)、4种(8.3％)5种(10.4％)、5种(10.4％)、5种(10.4％).2009、2010年影响因子排名前十名的期刊自引率明显高于其余38种期刊[0.11(0.04 ～0.40)vs.0.06(0.02～0.42),Z=-2.103,P =0.035;0.09(0.05 ～0.28) vs.0.06(0.02～0.39),Z=-2.254,P =0.012]. 2006、2007、2010年总被引频次排名前十名的期刊自引率均明显高于其余38种期刊[0.085(0.05～0.49) vs.0.065(0.01 ～ 0.29),Z=-2.206,P=0.027;0.07(0.05 ～0.44) vs.0.05(0.01 ～0.32),Z=-2.221,P=0.026;0.10(0.04 ～0.26) vs.0.06(0.02～0.39),Z=-2.052,P=0.040].2006～2010年48种外科学类期刊的自引率与影响因子呈正相关(r=0.547,P=0.000;r =0.562,P=0.000;r =0.510,P=0.000;r=0.458,P=0.001;r=0.489,P=0.000),自引率与总被引频次呈正相关(r=0.524,P=0.000;r =0.562,P=0.000;r =0.399,P=0.005;r =0.357,P=0.013;r=0.335,P=0.020).由此得出结论,2006～2010年48种外科学类期刊自引率参差不齐,差别较大,少数期刊存在过度自引现象;2006～2010年48种外科学类期刊自引率与影响因子和总被引频次呈正相关性. 相似文献
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To elucidate a higher rate of premature cardiovascular disease (CVD) in Asian Indian descendants (Roma) in Slovakia, we investigated frequency distribution, correlates and relationship of lipoprotein(a) [Lp(a)] to family CVD risk factors in Roma children and their Caucasian neighbors. The study sample consisted of 607 healthy children aged 7–18 years (55% Roma, 48% male) as part of the biracial (Roma–Caucasian) Slovak Lipid Community Study. Overall, frequency distribution data of Lp(a) were highly skewed to low concentrations, with markedly higher Lp(a) levels in Roma than in Caucasian children (median and range, mg/dL: 14.5; 0–159.2 vs 6.2; 0–112.3, P < 0.001), regardless of age and gender. Lp(a) was positively correlated with apo B (0.159, P = 0.004) in Roma, and LDL cholesterol (0.170, P = 0.005) in Caucasian children. In addition, daily income of the family was negatively related with Lp(a) in Roma (−0.134, P = 0.036) while positively in Caucasians (0.136, P = 0.047). For both race groups, no significant association was found between Lp(a) and age, body mass index, mean arterial pressure, smoking, and physical activity. Also, no significant relationships were examined between serum Lp(a) levels >30 mg/dL in children and family CVD risk factors, except for diabetes mellitus in parents of Caucasian origin (OR 4.46; 95%CI: 1.23–16.20). In a multivariate analysis, daily income, LDL cholesterol or apo B explained ~7% of the variance of Lp(a). This study suggests a significantly higher serum Lp(a) levels in Roma than in Caucasian children and a small effect, in general, of relevant CVD risk factors on the variation of Lp(a) levels in childhood. 相似文献
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杭州市1319名正常成年人骨密度测定分析 总被引：1，自引：0，他引：1
对杭州市1319名正常成年人尺、桡骨骨密度(BMD)的测定结果进行分析,发现性别与增龄因素对BMD有显著影响,BMD随增龄而变化的特点是女性达峰早、下降快,男性达峰迟、下降慢.正常成年人男性BMD比女性高(P<0.01).一般性OP发病率随增龄而上升,但性别差异不显著(P>0.05).基于尺骨BMD与桡骨BMD差异不显著(P>0.05),加之这二项BMD指标与尺桡骨平均BMD相互间均呈高度正相关关系(P<0.01),所以将尺桡骨平均BMD这一单项指标作为活体骨矿物含量的综合评定指标是可行的.本研究还表明在女性体重指数(BMI)与BMD之间有正相关关系存在(P<0.05),提示消瘦可能是女性OP发病的危险因子. 相似文献
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运用三元能量处理５个油菜品种，同时设对照，进行试验，产量统计结果是，处理的对照相比人武部增产，增幅为３．０１％－１３．１８％，平均为８．４８％，ｔ－检验表明增产显著。经济性状调查结果是，三元能量处理与对照相比，平均株高增加３．４６ｃｍ，平均有效分数增加０．３８个，平均有较分枝部位降低２．６９ｃｍ，平均单株角果数增加２．９２个，平均角果粒数增加０．２４粒，千粒重增加０．１５ｇ。 相似文献
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对５６例消化性溃疡患者，平分两组分别用奥美拉唑及进口洛赛克治疗４周。结果：奥美后唑总有效率９６％，洛赛克１００％，两者差异无显著性；两组治疗前后快速尿素酶试验阳性率相比差异无显著性；治疗前与治疗后胃液ｐＨ值相比两组差异均有高度显著性。奥美拉唑费用低，有推广价值。 相似文献
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Rohit Kumar Gupta Sagar Jayantilal Dholariya Smita Kaushik S. K. Gupta Reva Tripathi Shyam Lata Jain 《Indian journal of clinical biochemistry : IJCB》2021,36(2):221
Ovarian cancer has been emerged as a most common and lethal gynecological malignancy in India. High serum insulin and low adiponectin have been associated with increased risk of ovarian cancer. But their role in development of ovarian cancer is conflicting and little evidence is available. We aimed to evaluate blood levels of insulin and adiponectin in epithelial ovarian cancer (EOC) patients and their association with the risk to develop EOC. The study included following three groups; Group 1: fifty cases of cytohistopathologically confirmed cases of EOC, Group 2: fifty age matched cases of benign ovarian conditions and Group 3: fifty ages matched healthy controls with no evidence of any benign or malignant ovarian pathology as ruled out by clinical examination and relevant investigations. Cytohistopathologically confirmed and newly diagnosed cases of EOC and benign ovarian cancer were included in this study. The median value of fasting serum insulin was significantly high (15.0 µlU/ml, P = 0.02) and adiponectin were significantly low (5.1 µg/ml, P < 0.001) in ovarian cancer patients compared to benign ovarian tumors and healthy controls group. A significant increase risk of ovarian cancer was found in high tertile (≥ 18.7 µlU/ml) of serum insulin level (OR = 2.7; 95% CI = 1.00–6.67, P = 0.04) and lower tertile (≤ 5.45 µg/ml) of adiponectin level (OR = 3.2; 95% CI = 1.10–9.71, P = 0.03). High serum insulin level and low adiponectin levels were significantly associated with increased risk for development of ovarian cancer. 相似文献
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中国东北北部黑土重金属污染趋势分析 总被引：46，自引：0，他引：46
对中国东北北部 2 2个县市黑土可能发生重金属污染的污染源进行了系统调查 ;对土壤样品中Cd、Pb、Cu、Zn进行检测分析 ,4种重金属的检出范围依次为 0 0 1 3— 2 31mg kg ,1 0 5 2— 5 7 48mg kg ,42 1 3— 2 2 7 1 0mg kg和 9 95— 46 1 8mg kg .结合单污染指数评价法和表底土比较 2种方法进行污染评判 ,结果表明 ,土壤样品中重金属Cd的污染最为明显 ,其污染多集中在中度和重度水平 .对于重金属Pb、Zn和Cu的污染用单污染指数评判没有准确反映污染的真实情况 ,同时说明不同评判方法的精确性有较大的差距 .用表底土比较法对Pb、Cu、Zn 3种重金属进行评判 ,发现其在采样区域的污染水平仍非常明显 ,依次有 5 7 1 %,2 1 0 %和 5 3 3%的表土样品受到这 3种重金属不同程度的污染 .大部分受到污染的土壤样点大多集中在市内工业区附近土壤和城乡结合部菜地 相似文献
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Waleed Tamimi Esam Albanyan Yasmin Altwaijri Hani Tamim Fahad Alhussein 《Indian journal of clinical biochemistry : IJCB》2012,27(2):141-146
Reference intervals for pubertal characteristics are influenced by genetic, geographic, dietary and socioeconomic factors. Therefore, the aim of this study was to establish age-specific reference intervals of glucose and lipid levels among local school children. This was cross-sectional study, conducted among Saudi school children. Fasting blood samples were collected from 2149 children, 1138 (53%) boys and 1011 (47%) girls, aged 6 to 18 years old. Samples were analyzed on the Architect c8000 Chemistry System (Abbott Diagnostics, USA) for glucose, cholesterol, triglycerides, HDL and LDL. Reference intervals were established by nonparametric methods between the 2.5th and 97.5th percentiles. Significant differences were observed between boys and girls for cholesterol and triglycerides levels in all age groups (P < 0.02). Only at age 6–7 years and at adolescents, HDL and LDL levels were found to be significant (P < 0.001). No significant differences were seen in glucose levels except at age 12 to 13 years. Saudi children have comparable serum cholesterol levels than their Western counterparts. This may reflect changing dietary habits and increasing affluence in Saudi Arabia. Increased lipid screening is anticipated, and these reference intervals will aid in the early assessment of cardiovascular and diabetes risk in Saudi pediatric populations. 相似文献
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Surupa Basu Ruchi Gupta Monjori Mitra Apurba Ghosh 《Indian journal of clinical biochemistry : IJCB》2015,30(2):167-173
Vitamin D deficiency is highly prevalent in Indian children of northern, western and southern states. Serum 25 hydroxy cholecalferol (ng/ml) was analyzed in 310 children and adolescents of pediatric hospital of Kolkata, India. Serum calcium (mg/dl), phosphorous (mg/dl) and alkaline phosphatase (IU/L) data was obtained. Median 25(OH)D was 19 ng/ml. 19.2 % of population had serum 25(OH)D < 10 ng/ml (severe deficiency), 52.9 % had <20 ng/ml (deficiency), 24.5 % had 20–29 ng/ml (insufficiency) and 22.6 % had >30 ng/ml (optimum). Deficiency was highest in adolescents (86.1 %), followed by school children (61.0 %), lowest in pre-school children (41.6 %). 25(OH)D concentrations was lowest in winters (P = 0.002) and spring (P = 0.03) compared to summer. There was no correlation with calcium (P = 0.99), phosphorous (P = 0.23) and ALP (P = 0.63). There is high prevalence of vitamin D deficiency in children and adolescents of eastern India. Prevalence was lower in younger subjects. 25(OH)D did not correlate with bone mineral markers. 相似文献