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1.
Corsetti R Lombardi G Barassi A Lanteri P Colombini A D'Eril GM Banfi G 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(2):237-246
Introduction
The study of cardiac response to strenuous and continuous exercise is crucial to understanding the physiology of endurance. N-terminal proB-type natriuretic peptide (NT-proBNP) is a potential marker for monitoring myocardial wall stress, and troponins (TnT and TnI) are widely used in the diagnosis of cardiac ischemia and infarction. Strenuous exercise may generate transitory ischemia, myocardial stress, and diastolic left ventricular dysfunction, inducing the increased production of both these biomarkers. We measured changes in NT-proBNP and TnT in elite cyclists during a 3-week stage race, a model of strenuous exercise.Materials and methods:
The study population was 9 professional cyclists participating in the 2011 Giro d’Italia. Pre-analytical and analytical phases scrupulously followed official recommendations. Anthropometric data, net energy expenditure and cardiac indexes (rate, diastolic and systolic blood pressure) were recorded. Blood samples were drawn pre-race (day −1) and at days 12 and 22; NT-proBNP and highly sensitive-troponin (Hs-TnT) concentrations were assayed and corrected for plasma volume changes.Results:
Body-mass index decreased and energy expenditure increased by 52% during the race. NT-proBNP concentrations increased [day −1: 23.52 ng/L (9.67–34.33); day 12: 63.46 ng/L (22.15–93.31); P = 0.039; day 22: 89.26 ng/L (34.66–129.78) vs. day −1; P < 0.001] and correlated with heart rate (r = −0.51; P = 0.006), systolic pressure (r = 0.39; P = 0.046) and energy expenditure (r = 0.70; P < 0.001). TnT concentrations did not vary, but a widened TnT amplitude distribution was observed.Conclusions:
Increases in NT-proBNP correlated with higher energy expenditure over a 3-week cycling stage race, possibly indicating myocardial stress. 相似文献2.
J. I. Anetor F I Ajose T. S Akingbola 《Indian journal of clinical biochemistry : IJCB》2005,20(1):193-197
A 64-year-old security guard and longstanding known hypertensive presented with hypertensive heart disease (HHD), weight loss,
an enlarged prostate, and a spontaneously fractured rib. Malignancy of the prostate with possible metastases to the ribs was
strongly suspected. Biochemical profiling revealed a paraprotein. Other biochemical and hematological correlates that were
on hand before serum protein electrophoresis were rather atypical. Paraprotein studies by immunofixation revealed IgA myelomatosis.
Unlike previous reports from Caucasians there was normocalcaemia, normal protein level, microcytic hypochromia, low MCHC,
cholesterol level at the lower limit of the reference range and normal urea level (in the face of markedly raised creatinine
level). Nutritional modulation of the classical laboratory features of this disease may account for the fairly atypical laboratory
picture.
The need to appreciate the influence of nutritional status on the laboratory (especially biochemical) features of a disease
and thus interpretation of diagnostic tests appears of exceptional current importance, given the widening gap in socioeconomic
status and the level of poverty between the resource poor and developed countries from which the classical, clinical and laboratory
features of most diseases were first described.
This case report reminds of the need not only to recognize theoretically the impact of nutritional status on the laboratory
characteristics of a disease but of the practical application of the nutritional perspective in the interpretation of diagnostic
investigations, especially in nutritionally disadvantaged communities. 相似文献
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Casikar V Mujica E Mongelli M Aliaga J Lopez N Smith C Bartholomew F 《Indian journal of clinical biochemistry : IJCB》2010,25(3):311-314
Andean Indians have used coca leaves (Erythroxylon coca and related species) for centuries to enhance physical performance. The benefits and disadvantages of using coca leaf have
been a subject of many political debates. The aim of this study was to investigate the effects of chewing coca leaves on biochemical
and physiological parameters. Cutaneous microdialysis catheters were used to estimate systemic biochemical changes. We subjected
10 healthy adult males (local residents) in Cajamarca (Peru, altitude 2700 m) to a standardised exercise routine on a stationary
cycle ergometer. The blood pressure, oxygen saturation (digital), pulse, VO2 max and ECG (Holter monitor) were recorded before
the exercise. Cutaneous microdialysis catheters were introduced in the forearm. The subjects were given to chew 8 g of coca
leaves with a small amount of lime. They were then placed on the cycle ergometer for 20 min. Blood pressure, oxygen saturation,
pulse, ECG and VO2 max were recorded. Pyruvate, glucose, lactate, glycerol and glutamate levels were estimated. Oxygen saturation,
blood pressure, and pulse rate did not show any significant changes between the two groups. Glucose levels showed hyperglycaemic
response. Glycerol, Lactate and Pyruvate increased. Glutamate remained unchanged. Similar changes were not seen in the controls.
These results suggest that coca leaves have blocked the glycolytic pathway of glucose oxidation resulting in accumulation
of glucose and pyruvate. The energy requirement for exercise is being met with beta-oxidation of fatty acids. The glycerol
released was also getting accumulated since its pathway for oxidation was blocked. These experimental findings suggest that
chewing coca leaves is beneficial during exercise and that the effects are felt over a prolonged period of sustained physical
activity. 相似文献
4.
应当重视工作在公安一线的警员身体状况,清醒地认识到警员体能训练不仅关系到身体素质、运动能力和实战中的应变能力的变化,而且还关系到警员在查缉技能、战术等方面及至搏斗中的生死存亡等严肃问题。 相似文献
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Introduction:
Intensive exercising may significantly damage muscles which is reflected in pain, fatigue and the increase of muscle proteins concentrations in blood such are creatinin kinase (CK), lactic dehydrogenase (LD), myoglobin (MB) and other biochemical parameters including urea serum concentration (SU). Biochemical markers vary with age, sex, race, muscle mass, physical activity and climate conditions. They also assist us in determining the limit between the capacity for adaptation to given training process which results in supercomepensation and in condition of overtraining (OT), in the case of load that exceeds the physiologic potential of regeneration. Concerning the problem of diagnosis and explanation of the symptoms of overtraining, markers that can apply reliably and with sufficient sensitivity and simplicity of interpretation in the praxis are sought. It is critical to take into account difference among individuals and groups that could hamper the interpretation.The most frequently used markers:
The most frequently used biomarkers that provide us with the information on physical activity and on the amount of load through exercise are CK, SU and LD. Level of serum retaining kinas has been measured and interpreted for years as part of different scientific and professional investigations and presents one of basic parameters for determining the level of muscle damage. It reaches maximal concentration of the fourth day of exercising which depends on the type of exercise and the nature of stress triggered by exercise but also on individual characteristics.The level of serum urea presents marker of nitric compounds metabolism and is the principle chemical substance in the urine of mammals. It is thus possible to draw a parallel between the increases of serum urea concentration on increased degradations of proteins. Significant fall of serum amino acid levels occurs after sixty to seventy minutes of exercising with the increase of urea and free tyrosine and these changes have high correlation with the duration and intensity of.LD changes are important index of well-trained sportsmen and their capability to withstand the pace and force during strain in the training process. The level of LD is a good index of exercise intensity and marker of metabolic exchange in tissues whose concentration in serum is dependent of cell damage.Conclusion:
There is not a single, unique parameter that would provide enough valuable information for the estimation of the quality of exercising, amount of load and identification of overtraining. Delayed measurement of biomarkers is far from ideal, but it is obvious that the amount of stress/ load in training is the most important factor for the development of state of overtraining. Daily body weight control, diet, biochemical indices values and the input of water should be known and standardized before measurements. For the most of parameters determination of basal levels are needed in specific populations for more accurate interpretation and evaluation of results. The sampling process itself should be under the most strict conditions of standardization by repeating measurement at least every third day. Dependence of mentioned parameters (SU, CK, LD) on exercise intensity varies among individuals and without these additional measurements and subpopulation evaluations it is difficult to come to conclusions with certainty as well as to come to conclusions on causative correlations of training load and dynamic in biochemical parameters.Biochem Med (Zagreb) 2013 Jun; 23(2): A57–A58. Published online 2013 Jun 15. doi: 10.11613/BM.2013.027Common sports injuries
Miljenko FranićAuthor information Copyright and License information DisclaimerDubrava University Hospital, ZagrebCorresponding author: rh.dbk@cinarfm©Copyright by Croatian Society of Medical Biochemistry and Laboratory MedicineThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.Sports injuries are injuries that occur in athletic activities and can be broadly classified as either traumatic or overuse injuries. Traumatic injuries because of the dynamic and high collision are nature of some sports. Overuse injuries cause wear and tear on the body, particularly on joints subjected to repeated activity.At every age, competitive and recreational athletes sustain a wide variety of soft tissue, bone, ligament, tendon and nerve injuries, caused by direct trauma or repetitive stress. Different sports are associated with different patterns and types of injuries, whereas age, gender and type of activity influence the prevalence of injuries. Sports trauma commonly affects joints of the extremities or the spine.The hip, knee and ankle are at risk of developing osteoarthritis (OA) after injury or in the presence of malalignment, especially in association with high impact sport. Spine pathologies are associated more commonly with certain sports. Upper extremity syndromes caused by a single stress or by repetitive micro-trauma occur in a variety of sports.Random control trials expose some subjects, but not others, to an intervention. This is more clinical in nature and not typically appropriate for the study of injury patterns. Cohort studies monitor both injured and non-injured athletes, thereby providing results on the effects of participation. Case-control studies monitor only those athletes who suffered an injury. The Ideal study would be Cohort design conducted over several teams, with longitudinal prospective data collection and one recorder where possible, as well as uniformity of injury definition across sports so comparisons between studies can be made accurately.Physical injury is an inherent risk in sports participation and, to a certain extent, must be considered an inevitable cost of athletic training and competition. Injury may lead to incomplete recovery and residual symptoms, drop out from sports, and can cause joint degeneration in the long term.Advances in arthroscopic techniques allow operative management of most intraarticular post-traumatic pathologies in the lower and upper limb joints, but long-term outcomes are not available yet. It is important to balance the negative effects of sports injuries with the many benefits that a serious commitment to sport brings.Biochem Med (Zagreb) 2013 Jun; 23(2): A58–A59. Published online 2013 Jun 15. doi: 10.11613/BM.2013.027Determination of sample size and number of study groups in sport studies
Mladen PetrovečkiAuthor information Copyright and License information DisclaimerDepartment of Laboratory Diagnosis, Dubrava University Hospital, Zagreb, Croatia, and Department of Medical Informatics, Rijeka University School of Medicine, RijekaCorresponding author: rh.irdem@pnedalm;©Copyright by Croatian Society of Medical Biochemistry and Laboratory MedicineThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 相似文献7.
游泳不单纯是一项体育竞技运动,从人们的现代气息生活方式来看,游泳还是强身健体、休闲娱乐的锻炼方式,因此游泳运动越来越受到人们的欢迎。各种泳姿中,蛙泳技术是最为基础、也最为方便易学的一种泳姿。本文主要通过研究蛙泳教学中,核心区力量训练对学生蛙泳教学效果的对比分析,为学生的游泳教学提供更好的训练。 相似文献
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Prasanthi Mannava Afshan Masood Ambika K. Devi 《Indian journal of clinical biochemistry : IJCB》2015,30(1):113-116
Albright hereditary osteodystrophy (AHO) is a rare hereditary metabolic disorder that may or may not be associated with resistance to parathyroid hormone (pseudohypoparathyroidism) or other hormones. The disorder is commonly characterized by a constellation of dysmorphic physical features and with biochemical levels that demonstrate hypocalcaemia and hyperphosphatemia. We report here a clinical case of a 14 year old male with AHO and we discuss his clinical features, radiographic and laboratory findings along with treatment. 相似文献
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本文围绕现场测量,统计数据来分析,测量安静状态下准备活动中、剧烈运动后,恢复时期心跳、呼吸次数与绿色植物的关系。 相似文献
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Parsunpriya Nayak Subir Kumar Das D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2006,21(2):53-57
Aluminum and alcohol, both are well-accepted neurotoxin. The plausible mechanisms for their neurotoxicity are also common.
Therefore, the effect of ethanol on aluminum induced biochemical changes in rat brain is being studied. In the present study,
ethanol exposure significantly affected the aluminum and protein content of brain. The activities of acid phosphatase and
alkaline phosphatase were also changed. Aluminum exposure, on the other hand, contributed significantly in the alterations
of aluminum content, acid phosphatase acivity and aspartate aminotransferase activity. Though ethanol co-exposure significantly
influenced the aluminum load of brain, the interactions of these two neurotoxins were found to be significant only in case
of acid phosphatase activity of brain. Therefore, it can be suggested that general neurotoxicity produced by aluminum is not
modified by ethanol. However, the aluminum load caused by aluminum exposure, may be influenced by ethanol co-exposure. 相似文献
11.
农村中学体育术科考生在平时的运动训练中,有几种现象直接或间接地影响到了考生的考试成绩,农村体育考生选择了体育作为自己的通往大学之路,带训体育教师,文章对农村体育术科考生训练中的几种现象加以分析,找出对策,总结一些有效的训练经验,为考生取得良好的成绩提供帮助。 相似文献
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《Information processing & management》2022,59(5):103034
Adequate adherence is a necessary condition for success with any intervention, including for computerized cognitive training designed to mitigate age-related cognitive decline. Tailored prompting systems offer promise for promoting adherence and facilitating intervention success. However, developing adherence support systems capable of just-in-time adaptive reminders requires understanding the factors that predict adherence, particularly an imminent adherence lapse. In this study we built machine learning models to predict participants’ adherence at different levels (overall and weekly) using data collected from a previous cognitive training intervention. We then built machine learning models to predict adherence using a variety of baseline measures (demographic, attitudinal, and cognitive ability variables), as well as deep learning models to predict the next week's adherence using variables derived from training interactions in the previous week. Logistic regression models with selected baseline variables were able to predict overall adherence with moderate accuracy (AUROC: 0.71), while some recurrent neural network models were able to predict weekly adherence with high accuracy (AUROC: 0.84-0.86) based on daily interactions. Analysis of the post hoc explanation of machine learning models revealed that general self-efficacy, objective memory measures, and technology self-efficacy were most predictive of participants’ overall adherence, while time of training, sessions played, and game outcomes were predictive of the next week's adherence. Machine-learning based approaches revealed that both individual difference characteristics and previous intervention interactions provide useful information for predicting adherence, and these insights can provide initial clues as to who to target with adherence support strategies and when to provide support. This information will inform the development of a technology-based, just-in-time adherence support systems. 相似文献
16.
本文对现在高校学生对篮球训练方法的误区以及纠正办法、身体素质在篮球运动中的重要性加以分析,从而进一步强调身体素质训练对篮球运动的重要性。 相似文献
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Subir Kumar Das Prasunpriya Nayak D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2003,18(2):111-118
A variety of laboratory tests are available to assist in the diagnosis of alcohol consumption and related disorders. The levels
of intake at which laboratory results become abnormal vary from person to person. Laboratory tests are particularly useful
in settings where cooperativeness is suspected or when a history is not available. Several biochemical and hematological tests,
such as γ-glutamyltransferase (GGT) activity, aspartate aminotransferase (AST) activity, high-density lipoprotein cholesterol
(HDL-C) content of serum, and erythrocyte mean corpuscular volume (MCV) are established markers of alcohol intake. Their validity
as markers is based largely on correlations with recent intake at a single time point and on decreases in elevated values
when heavy drinkers abstain from alcohol. These readily available laboratory tests provide important prognostic information
and should be integral part of the assessment of persons with hazardous alcohol consumption. There are several other markers
with considerable potential for more accurate reflection of recent alcohol intake. These include carbohydrate deficient transferrin,
β-hexosaminidase, acetaldehyde adducts and the urinary ratio of serotonin metabolites, 5-hydroxytryptophol and 5-hydroxyindoleacetic
acid. These markers provide hope for more sensitive and specific aids to diagnosis and improved monitoring for intake. 相似文献
18.
本研究通过对参加中长跑训练备战福建省第十四届大学生运动会的10名大学生（男）运动员训练前后身体成分、心血管、心肺功能等生理指标的观察,探讨耐力训练前后对大学生健康体适能的影响,本研究将以耐力训练对大学生心肺功能及身体成分等方面的影响作为依据,为进一步科学指导大学生体育锻炼提供参考。 相似文献
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在体育教学中采取多元化的评价机制,一方面可以调动学生学习和训练的积极性,激发学生参加体育学习和训练的兴趣,培养学生参加体育锻炼的习惯和爱好;另一方面还可以提升教师的主导地位,提高教学质量,增强训练效果。采取多元化的教学评价机制,既是一项对训练价值进行判断的目标活动,同时又是对客观训练满足学生主体需要程度的判断。 相似文献
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采用文献资料法,问卷调查法对渭南师院900名在校女大学生进行有关体育锻炼态度和行为的调查,结果显示:a.女生体育人口较低,锻炼次数偏少,女大学生的锻炼现状不容乐观。b.经常参加的锻炼项目女生主要是羽毛球、跑步、跳绳健美操等;锻炼形式以和同学或朋友一起为主。c.没有时间、学习任务重和锻炼设施不足等是影响学生参加锻炼的客观原因。 相似文献