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1.
Objective: This study was aimed at evaluating and comparing the quality of life in patients who underwent laparo-scopic and open cholecystectomy for chronic cholecystolithiasis. Methods: The study included 25 patients with laparoscopic cholecystectomy (LC group) and 26 with open cholecystectomy (OC group). The quality of life was measured with the Gastrointestinal Quality of Life Index (GLQI) preoperatively, thereafter regularly at 2, 5, 10 and 16 weeks after the operation. Results: The mean preoperative overall GLQI scores were 112.5 and 110.3 in LC and OC group respectively (P>0.05). In the LC group, the mean overall GLQI score reduced slightly to 110.0 two weeks after the operation (P>0.05). The LC group showed significant improvement in overall score and in the aspects of symptomatology, emotional and physiological status from 5 to 16 weeks postoperatively. In the OC group, the GLQI score reduced to 102.0 two weeks after surgery (P<0.05). Significant reductions were shown in the aspects of symptomatology, physiological and social status. The GLQI scores returned to the preoperative level of 115.6 ten weeks after the operation (P>0.05). The patients experienced significant improvements of GLQI sixteen weeks after OC operation (P<0.01-0.05). Within the 10 postoperative weeks, the LC group had significantly higher GLQI scores than the OC group (P<0.05). Conclusions: LC can improve the quality of life postoperatively better and more rapidly than OC. The assessment of quality of life assessment is a valid method for measuring the effects of surgical treatment.  相似文献   

2.
The objective of this study was to investigate the endosonographic appearance of gastric linitis plastica(GLP) and to study the usefulness of endoscopic ultrasonography(EUS) for the T and N staging of GLP.EUS examinations of 55 patients with histologically proven GLP were retrospectively studied.In all patients,EUS showed that lesions involved at least one-third of the circumference of the stomach.Based on the findings of the EUS,the 55 patients were divided into two groups.There were 32(58.2%) patients in the first group.EUS of this group showed that the five sonographic layers had disappeared and had been replaced by a hypoechogenic thickening of the gastric wall.There were 23(41.8%) patients in the second group.EUS of this group showed that the first three sonographic layers were blurred and thickened,and the fourth layer was significantly thickened.The full thickness of the gastric wall was significantly thicker in first than in the second group of patients(P<0.01).The incidence of perigastric lesions was significantly higher in the first than in the second group of patients(P<0.01).Results for the 15 patients following preoperative EUS were compared postoperatively with histopathologic findings for T and N staging.The overall diagnostic accuracy of the T stage was 73.3% and of the N stage was 60.0%.In eight patients,we used EUS to assess a therapeutic response.No response was observed in five patients and a partial response in three.EUS images of GLP are characteristic.EUS is helpful in diagnosing GLP and for assessing the T and N stages.  相似文献   

3.
Malignant gliomas are the most devastating tumors in clinical practice and nave poorest survival, Immunological treatment of such patients may likely increase the survival and quality of life. Dendritic cells （DCs）, most potent antigen presenting cells in combination with oral chemotherapeutic agents may be tried for patients giving consent to such treatment. We have successfully combined the two therapies in an adult male patient who was on downhill course after being operated on once with post operation chemotherapy and radiotherapy for glioma in the left parietal area. He received five dendritic cell therapy vaccines in combination with oral chemotherapy and responded dramatically having near normal quality of life for an additional five months with this regime, increasing the survival after operation to 11 months. This therapy is continuing with radiological betterment of the lesion. The DCs are matured with antigen extracted from wax embedded tissue at 6th day of culture. We feel that the treatment can be given to more number of patients to establish its efficacy for the dreaded cancer glioblastoma multiforme.  相似文献   

4.
Objective: To investigate the directed transplantation of allograftic bone marrow-derived mesenchymal stem cells (MSCs) in myocardial infarcted (MI) model rabbits. Materials and Methods: Rabbits were divided into 3 groups, heart infarcted model with MSCs transplanted treatment (MSCs group, n=12), heart infarcted model with PBS injection (control group, n=20), sham operation with PBS injection (sham group, n=l 7). MSCs labelled by BrdUrd were injected into the MI area of the MSCs group. The same volume of PBS was injected into the MI area of the control group and sham group. The mortality, LVIDd, LVIDs and LVEF Of the two groups were compared 4 weeks later. Tropomyosin inhibitory component (Tn I) and BrdUrd immunohistochemistry identified the engrafted cells 4 weeks after transplantation. Result: The mortality of the MSCs group was 16.7% (2/12), and remarkably lower than the control group's mortality [35% (7/20) (P＜0.05)].Among the animals that survived for 4 weeks, the LVIDd and LVIDs of the MSCs group after operation were 1.17±0.21 cm and 0.74±0.13 cm, and remarkably lower than those of the model group, which were 1.64±0.14 cm and 1.19±0.12 cm (P＜0.05); the LVEF of the MSCs group after operation was 63±6%, and remarkably higher than that of the model group,which was 53±6% (P＜0.05). Among the 10 cases of animals that survived for 4 weeks in the MSCs group, in 8 cases (80%),the transplanted cells survived in the non MI, MI region and its periphery, and even farther away; part of them differentiated into cardiomyocytes; in 7 cases (70%), the transplanted cells participated in the formation of blood vessel tissue in the MI region. Conclusion: Transplanted allograftic MSCs can survive and differentiate into cardiomyocytes, form the blood vessels in the MI region. MSCs transplantation could improve the heart function after MI.  相似文献   

5.
Although cardiac rupture (CR) is a fatal mechanical complication of acute myocardial infarction (AMI), to date no predictive model for CR has been described. CR has common pathological characteristics with major bleeding. We aimed to investigate the relationship between the risk factors of major bleeding and CR. A total of 10 202 consecutive AMI patients were recruited, and mechanical complications occurred in 72 patients. AMI patients without CR were chosen as control group. Clinical characteristics including bleeding-related factors were compared between the groups. The incidences of free wall rupture (FWR), ventricular septal rupture (VSR), and papillary muscle rupture (PMR) were 0.39%, 0.21%, and 0.09%, respectively, and the hospital mortalities were 92.5%, 45.5%, and 10.0%, respectively. Female proportion and average age were significantly higher in the groups of FWR and VSR than in the control group (P<0.01); higher white blood cell count and lower hemoglobin were found in all CR groups (P<0.01). Compared to the control group, patients with CR were more likely to receive an administration of thrombolysis [26.39% vs. 13.19%, P<0.05], and were less likely to be treated with primary percutaneous coronary intervention (PCI) [41.67% vs. 81.60%, P<0.05]. The major bleeding scores (integer scores) of FWR, VSR, and PMR were (17.70±7.24), (21.91±8.33), and (18.60±7.88), respectively, and were significantly higher than that of the control group (11.72±7.71) (P<0.05). A regression analysis identified age, increased heart rate, anemia, higher white blood cell count, and thrombolysis as independent risk factors of CR, most of which were major bleeding-related factors. The patients with CR have a significantly higher risk of hemorrhage compared to the group without CR. Risk of CR after AMI is related to the risk of hemorrhage.  相似文献   

6.
Objective:To estimate the impact of autologous transfusion on the status of perioperative immune activation inmalignant tumor patients.The Serum Neopterin and Interleukin-2(IL-2)were measured.Methods:Sixty patients undergoingelective radical resection for malignant stomach tumor were enrolled in the prospective study and assigned to the following groups:(Ⅰ)Group A received autologous transfusion;(2)Group H received allogeneic transfusion.The perioperative course(Beforeinduction of anesthesia,after operation and 5 d after operation)of Neopterin and IL-2 was compared.Results:In group A,SerumNeopterin was significantly lower than baseline alter operation and IL-2 had no significant changes.In group H,both SerumNeopterin and IL-2 were significantly lower than baseline alter operation and 5 d after operation.Compared with group A,SerumNeopterin was significantly lower than baseline alter operation and 5 d after operation and IL-2 was significantly lower thanbaseline 5 d alter operation.Conchision:Autologous  相似文献   

7.
Objective:To observe the periodontal healing of autogenously transplanted teeth loaded orthodontically after autotransplantation in Beagle dogs.Methods:Forty-eight teeth were autogenously transplanted,24 of which were loaded postoperatively with orthodontic force at different time points and for different durations.Periodontal healing was evaluated by probing pocket depth(PPD),the expression of relevant proteins,and histomorphometric analyses.Results:The dental pockets of loaded and non-loaded teeth were both much deeper after the first postoperative week than before transplantation(P<0.05).Later,the PPD,which was measured after postoperative weeks 1,3,5,9 and 13,gradually became shallow.The expressions of alkaline phosphatase(ALP)and basic fibroblast growth factor(bFGF)were higher in loaded teeth than in non-loaded teeth(P<0.05),and in groups subjected to two weeks duration of loading than in other groups at the same load time point(P<0.05).For the same load duration,the expressions of ALP and bFGF in teeth loaded after postoperative week 4 were higher than those of other treatments(P<0.05).According to histomorphometric analyses,an orthodontic force on transplanted teeth applied after postoperative weeks 4 or 8 for two weeks duration should be favorable for periodontal healing.Conclusions:It is advisable to apply an appropriate magnitude of force on autotransplanted teeth,such as orthodontic force,at appropriate time points and for a suitable duration,to achieve the optimal clinical prognosis following autogenous tooth transplantation.These results may serve as a basis for subsequent studies in humans so as to make clinical improvements.  相似文献   

8.
Objective: To determine the range of body temperature in a group of healthy Chinese term neonates over the first 72 hours of life and to assess the influence of body weight, gestational age and route of delivery. Method: All 200 consecutive cases of neonates delivered at our hospital from March to August 2001 were included in this retrospective study. Temperatures were measured immediately after delivery, after 30 minutes, 1 hour, 2 hours, 8 hours and 15 hours and on the 2nd and 3rd day. Axillary temperatures ranging from 36.5 oC to 37 oC were regarded as normal. No cases of maternal fever or systemic infection of the newborns were discovered. All infants were discharged in good general condition. Results: The mean rectal temperature at birth was 37.19 ℃. The lowest average temperature was reached at 1 hour after delivery (36.54 ℃) with a significant difference between natural delivery (36.48 ℃) and section (36.59 ℃) (P<0.05). Temperature subsequently rose to 36.70 ℃ at 8 hours and 36.78 ℃ at 15 hours (P<0.05). Hypothermia was seen in 51.8% and hypothermia in 42.5% of the patients. On the 3rd day after delivery, 96% of all temperatures were in the normal range. A significant relation was found between hypothermia and both low birth weight (P<0.001) and low gestational age (P<0.05). Conclusion: The reference range presently used did not include all physiological temperatures in the first 72 hours of life. Considering other factors, such as birth weight, route of delivery, gestational age and body temperature on the 2nd and 3rd day of life, may help to correctly assess the significance of temperatures beyond the reference range.  相似文献   

9.
Objective: The beneficial effect of percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) has been well established, but there is the problem of no-reflow phenomenon which is an adverse prognostic factor in primary PCI. In the present study the effect of a distal protection device (PercuSurge GuardWire; GW) on epicardial blood flow and myocardial perfusion was evaluated. Methods and Results: Patients with AMI were randomly divided into 2 groups, the GW and the control groups. The GW group included 52 patients with AMI who underwent primary PCI with GW protection and the control group included 60 patients who underwent primary PCI without GW protection. Epicardial blood flow in the infarct-related artery (IRA) and myocardial perfusion were evaluated according to the thrombolysis in myocardial infarction (TIMI) flow grade and the myocardial blush grade (MBG). We found TIMI score of 3 was obtained significantly more frequently in the GW group (96%) than in the control group (80%). The MBG score of 3 was obtained also significantly greater in the GW group (65%) than in the control group (33%). Conclusion: Primary PCI with GW protection can significantly improve epicardial blood flow and myocardial perfusion.  相似文献   

10.
Objective: To evaluate clinical, Quality of Life (QoL) and medical cost outcomes in patients with symptomatic reflux esophagitis (RE) receiving different ″triple combination therapy″. Methods: A multicenter medical effectiveness trial conducted in 10 hospitals of 5 regions in Zhejiang Province. 248 patient-volunteers were assigned to 8 weeks of ″ triple combination therapy″ with Lansoprazole plus Cisapride and Sucralfate or Ranitidine plus Cisapride and Sucralfate. Main outcomes assessment included symptoms scale scores, RE severity, QoL at baseline and 8 weeks. Medical cost data were collected with cost analysis questionnaire. Results: (1)More Lansoprazole group patients noted RE symptoms resolution than Ranitidine group(92.3% vs 78.4%, P<0.01). There was no striking difference between two groups in RE healing rate (90.8% vs 82.9%, P>0.05). (2)RE significantly impaired QoL of patients(P<0.001).Compared with Ranitidine group, QoL in Lansoprazole group had significant improvement (rate of ″good″ QoL 64.5% vs 45.6%, P<0.01). (3)There was close correlation between symptomic effectiveness and QoL rating scale in both the Lansoprazole and Ranitidine group(P<0.01, r=0.235 and 0.353 respectively). There were no statistical difference of medical cost between the two groups (P>0.05). Conclusion: RE significantly impaired QoL of patients. ″Triple combination therapies″ can significantly improve RE symptoms and QoL. Lansoprazole combination therapy was more cost-effective than Ranitidine combination group.  相似文献   

11.
目的：探讨腹腔镜胆囊切除术与开放胆囊切除术治疗胆囊结石的临床疗效。方法：选择2010年1月至2013年7月收治的胆囊结石患者共90例作为研究对象,按照治疗方式将其分为腹腔镜胆囊切除术（LC）组和开腹胆囊切除术（OC）组,比较两组患者疗效。结果：LC组手术时间、术中出血量、抗生素使用时间、胃肠功能恢复时间以及住院时间等围手术期指标均明显优于OC组（P〈0．05）;LC组并发症发生率为0．1％,OC组并发症的发生率3％,LC组并发症的发生率明显低于OC组（P〈0．05）。结论：腹腔镜胆囊切除术治疗胆囊结石术中出血少,术后恢复快,住院时间短,是一种安全可靠的治疗方式。  相似文献   

12.
目的:探讨辛伐他汀治疗脂肪肝的的临床疗效。方法:120例脂肪肝患者随机分为两组,辛伐他汀治疗组60例采用辛伐他汀20mg,每天1次口服;血脂康治疗组60例采用血脂康600mg,每天2次口服。8周为1个疗程,共3个疗程,观察辛伐他汀治疗组与血脂康治疗组的临床疗效、治疗前后血脂和B超变化情况,另选择同期体检证明为正常的健康者70人作为对照组。结果:辛伐他汀治疗组总有效率(93.1%)与血脂康组(90.3%)相似(P>0.05);辛伐他汀治疗组和血脂康治疗组治疗后与治疗前相比血总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL-C)均明显改善(P<0.01),辛伐他汀治疗组改善优于血脂康组(P<0.05或P<0.01),辛伐他汀治疗组与血脂康治疗组两组治疗后肝功能与治疗前相比均明显改善(P<0.01),但辛伐他汀治疗组与血脂康治疗组两组治疗后相比无显著差异(P>0.05),未见严重不良反应。结论:辛伐他汀是治疗高血脂和脂肪肝的有效药物之一,且副作用少,安全性大,值得临床应用。  相似文献   

13.
血清镍铬元素含量检测用于镍铬合金烤瓷冠修复的研究   总被引：12，自引：0，他引：12  
目的：研究镍铬合金烤瓷冠修复后血清中镍铬元素含量的变化，探讨镍铬合金长期存在于口腔中的安全性。方法：选取60名经体检合格且无任何病史的健康人作为正常对照组，采用石墨炉原子吸收光谱法测得其血清中镍铬元素含量；再从我院修复科选取60名上、下颌前牙有任意三颗行镍铬合金烤瓷冠修复后半年和一年的血清中镍铬元素含量作为实验组，并对实验组和对照组的镍铬元素含量进行分析。结果：血清镍含量：实验半年组与对照组比较无显著性差异（P〉0．05）；实验一年组与对照组相比较有显著性差异（P〈0．05）；实验一年组与半年组比较无显著性差异（P〉0．05）。血清铬含量：各组之间比较均无显著性差异（P〉0．05）。结论：镍铬合金烤瓷冠修复后会在口腔环境中释放一定的镍和铬，但量很微小，远低于对人体产生毒副作用的水平。  相似文献   

14.
目的:观察镍铬合金烤瓷冠修复后头发和血液中镍铬元素含量的变化,探讨镍铬合金长期存在于口腔中的安全性。方法:选取60名经体检合格的健康人作为正常对照组;60名上、下颌前牙有任意三颗行镍铬合金烤瓷冠修复的患者作为实验组。实验组修复后半年及一年和对照组均采用火焰原子吸收光谱法测定头发镍铬元素含量,采用石墨炉原子吸收光谱法测得其血清中镍铬元素含量。结果:头发镍含量:实验半年组与对照组比较无显著性差异(P>0.05);实验一年组与对照组相比较有显著性差异(P<0.05);实验一年组与半年组比较无显著性差异(P>0.05)。头发铬含量:各组之间比较均无显著性差异(P>0.05)。血清镍含量:实验半年组与对照组比较无显著性差异(P>0.05);实验一年组与对照组相比较有显著性差异(P<0.05);实验一年组与半年组比较无显著性差异(P>0.05)。血清铬含量:各组之间比较均无显著性差异(P>0.05)。结论:镍铬合金烤瓷冠修复后会在口腔环境中释放一定的镍、铬,且释放的量与时间有关,但量很微小,头发和血液中镍铬元素含量呈正相关。  相似文献   

15.
目的:探讨零缺陷护理模式对脑出血患者术后神经康复效果与生活质量的影响。方法:纳入赣州市人民医院2016年3月至2018年1月收治的、行手术治疗的100例脑出血患者作为研究对象,随机分为观察组(n=50)和对照组(n=50)。对照组采用心理疏导、健康宣教、切口护理、饮食指导等常规护理,观察组在对照组的基础上采用零缺陷护理模式。两组均干预1个月,收集并分析两组患者神经功能评分(NIHSS)、生活自理能力评分(FIM)及生活质量变化情况。结果:观察组干预后NIHSS评分低于对照组,差异具有统计学意义(P<0.05);观察组干预后FIM评分高于对照组,差异具有统计学意义(P<0.05);观察组一般健康状况、生活能力、生理职能、情感职能、躯体疼痛、生理机能、精神健康、社会功能评分均高于对照组,差异具有统计学意义(P<0.05)。结论:零缺陷护理模式能提高脑出血患者患者神经功能修复,提高患者日常生活活动能力,提高患者临床预后效果。  相似文献   

16.
INTRODUCTIONHypertensionisalwaysaccompaniedbyin creasesinarterywallthickness,mainlycausedbyproliferation ,hypertrophy ,migrationandap optosisofvascularsmoothmusclecells(VSMC) ,andelevatedcontentofconnectivetissue .Thesestructuralchangesinbloodvesselsarekn…  相似文献   

17.
目的分析分化型甲状腺癌术后~(131)I治疗患者应用协同模式对其心理状况及生活质量的影响。方法选取2018年10月~2020年10月在我院收治的甲状腺癌术后~(131)I治疗患者100例,采用随机数字表法将其分为两组,各50例。对照组患者采用常规模式干预,研究组采用协同护理模式,比较两组情绪、生活质量等改善情况。结果研究组干预后SAS评分,SDS评分,与对照组各评分比较差异明显(P<0.05)。干预后两组患者的自我效能评分均提升,且研究组干预后自我效能评分改善情况优于对照组(P<0.05)。两组干预后自护能力均较干预前改善,且研究组干预后自护能力总分及各项目评分均高于对照组(P<0.05)。研究组干预后癌因性评分低于对照组,组间差异明显(P<0.05)。且研究组干预后生活质量各维度评分高于对照组,研究组护理满意度为96.00%,与对照组的80.00%比较明显较高,P<0.05,差异有统计学意义。结论分化型甲状腺癌术后~(131)I治疗患者中应用协同护理模式,能够有效改善患者心理状况,减轻患者癌因性疲乏,增强患者自我效能感,从而提升患者自护能力,改善患者生活质量及满意度,在临床具有较高的应用价值。  相似文献   

18.
Objective:Atherosclerotic plaques and neovascularization play an important role in the course of coronary atherosclerosis.This study evaluated the effect of recombinant endostatin on experimental atherosclerotic plaques and neovascularization in rabbits.Methods:Eighteen healthy male rabbits were divided into three groups:control group,atherosclerotic model group,and recombinant endostatin treated group.The atherosclerotic model was established via a high-cholesterol diet after balloon catheter injury.The subject weights,serum total cholesterol,creatine kinase-myocardial band fraction(CKMB),and matrix metalloproteinase-2(MMP-2)were measured.Six weeks after treatment,the aortic roots were taken for pathological assay.The thickness ratio of the intima to media was measured by hematoxylin and eosin(HE)staining,and the number of neovessels was measured by immunohistochemistry via monoclonal antibody CD31 staining.Results:The weight,plasma total cholesterol,and CKMB were not significantly different between the atherosclerotic model group and the recombinant endostatin treated group,but much higher than those of the control group(P<0.05).The thickness ratio of the intima to media in the recombinant endostatin treated group was distinctly less than that in the atherosclerotic model group(P<0.05).The number of neovessels decreased dramatically(P<0.05)and the content of MMP-2 decreased slightly without statistical difference(P>0.05)in the recombinant endostatin treated group,compared to the atherosclerotic model group.Conclusions:Recombinant endostatin is able to inhibit the growth of neovascularization in the atherosclerotic plaque and the development of plaque.  相似文献   

19.
腹腔镜阑尾切除术与传统阑尾切除术疗效对比   总被引：2，自引：0，他引：2  
目的:比较腹腔镜阑尾切除术(laparoscopic appendectomy,LA)与传统剖腹阑尾切除术(open appendectomy,OA)的临床疗效。方法:将156例阑尾炎病例随机分成两组,一组72例行LA,另一组84例行OA,比较两种术式的手术时间、平均住院费用、住院时间,切口长度、术后镇痛剂应用、术后6h开始下床活动、术后24h内肛门排气例数、放置引流管率、切口感染等指标。结果:LA组的术后24h内肛门排气时间、放置引流管率、切口感染、平均住院时间、切口长度、粘连性肠梗阻、镇痛剂应用例数、术后6h开始下床活动例数与OA组比较,差异均有统计学意义(P<0.05);而两组手术时间比较差异无统计学意义(P>0.05);LA组住院费用较OA组明显增高(P<0.05)。结论:LA与OA比较,有手术损伤小、疼痛轻、恢复快、住院时间短、并发症少等优点,可作为大多数阑尾炎的首选手术方式。  相似文献   

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