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INTRODUCTIONHypertensionisalwaysaccompaniedbyin creasesinarterywallthickness,mainlycausedbyproliferation ,hypertrophy ,migrationandap optosisofvascularsmoothmusclecells(VSMC) ,andelevatedcontentofconnectivetissue .Thesestructuralchangesinbloodvesselsarekn… 相似文献
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Objective: To investigate the structural changes of aorta, and evaluate the effects of atorvastatin on the remodeling of thoracic
aorta in spontaneously hypertensive rats (SHR). Methods: Twelve eight-week-old SHR were randomized into atorvastatin treated
group (ATV group,n=6) and distilled water group (DW group,n=6); Wistar-Kyoto rats (WKY) were used as normal controls. Atorvastatin was administered to ATV group for 10 weeks by gavage
in mixture with distilled water(1 ml); the latter two groups were given the same amount of distilled water by gavage for 10
weeks. Systolic blood pressure of caudal artery was examined before and after treatment, and serum concentrations of total
cholesterol, triglycerides and HDL-C were measured. Wall thickness, media thickness, medial cross-sectional area and lumen
diameter of thoracic aorta were assessed with computed video processing. Results: Systolic blood pressure in ATV group was
markedly lower than that in DW group (P<0.01). Compared with DW group and WKY group, serum concentrations of total cholesterol, triglycerides and HDL-C in ATV group
were significantly lower (P<0.01,P<0.05). Wall thickness, media thickness, and medial cross-sectional area to lumen ratio in DW group were significantly higher
than those in WKY group and ATV group (P<0.01,P<0.05), but no such difference was found between WKY group and ATV group (P>0.05). Conclusion: Vascular structural changes of aorta are due to the alteration of the vessel wall in early stage of SHR.
Atorvastatin can markedly improve vascular remodeling. 相似文献
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