共查询到20条相似文献，搜索用时 453 毫秒
1.
A simple method of irreversibly sealing SU-8 microfluidic channels using PDMS is reported in this paper. The method is based on inducing a chemical reaction between PDMS and SU-8 by first generating amino groups on PDMS surface using N2 plasma treatment, then allowing the amino groups to react with the residual epoxy groups on SU-8 surface at an elevated temperature. The N2 plasma treatment of PDMS can be conducted using an ordinary plasma chamber and high purity N2, while the residual epoxy groups on SU-8 surface can be preserved by post-exposure baking SU-8 at a temperature no higher than 95 °C. The resultant chemical bonding between PDMS and SU-8 using the method create an interface that can withstand a stress that is greater than the bulk strength of PDMS. The bond is permanent and is long-term resistant to water. The method was applied in fabricating SU-8 microfluidi-photonic integrated devices, and the obtained devices were tested to show desirable performance. 相似文献
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This paper is concerned with integrated event-triggered fault estimation (FE) and sliding mode fault-tolerant control (FTC) for a class of discrete-time Lipschtiz nonlinear networked control systems (NCSs) subject to actuator fault and disturbance. First, an event-triggered fault/state observer is designed to estimate the system state and actuator fault simultaneously. And then, a discrete-time sliding surface is constructed in state-estimation space. By the use of a reformulated Lipschitz property and delay system analysis method, the sliding mode dynamics and state/fault error dynamics are converted into a unified linear parameter varying (LPV) networked system model by taking into account the event-triggered scheme, actuator fault, external disturbance and network-induced delay. Based on this model and with the aid of Lyapunov–Krasovskii functional method, a delay-dependent sufficient condition is derived to guarantee the stability of the resulting closed-loop system with prescribed H∞ performance. Furthermore, an observed-based sliding mode FTC law is synthesized to make sure the reachability of the sliding surface. Finally, simulation results are conducted to verify the effectiveness of the proposed method. 相似文献
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Gold nanoparticles (Au NPs) were directly synthesized on the surface of polyvinylsilazane (PVSZ, -[(vinyl)SiH-NH2]-) without use of extra reductive additives. The reductive Si-H functional groups on the surface of cured PVSZ acted as surface bound reducing agents to form gold metal when contacted with an aqueous Au precursor (HAuCl4) solution, leading to formation of Au NPs adhered to silicate glass surface. The Au NPs-silicate platforms were preliminarily tested to detect Rhodamine B (1 μM) by surface enhanced Raman scattering. Furthermore, gold microelectrode obtained by post-chemical plating was used as an integrated amperometric detection element in the polydimethylsilane-glass hybrid microfluidic chip. 相似文献
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大都市功能区块视角下的热岛影响因素空间分异 总被引：1，自引：0，他引：1
针对以往热岛影响因素研究中缺乏因子综合作用及作用程度空间异质性分析的现状,本文以大都市北京为研究区,利用兴趣点（POI）数据划分承载不同人类活动的用地功能区块,结合地理探测器探究在市域整体及不同用地功能区块中植被、水体、不透水面及社会经济要素等多维因素对地表温度的影响（单因子作用与因子交互作用）。结果表明：①各单因子、因子交互作用对于地表温度的影响程度在北京市14类用地功能区块中存在空间分异。单因子探测表明整体上植被对温度的影响力高达72.3%,其作用程度与社会经济因素作用程度的差距在人类活动较为频繁的区块显著缩小;②因子交互作用探测显示两因子交互作用对温度的影响远大于单因子作用效果,整体水平上植被与人口交互作用是控制温度分异的主导因子,解释力达到78.9%,而在包含商业服务或公共管理服务的区块植被与人口交互作用均为影响温度分异的主导因素,包含工业的区块则为不透水与经济水平、植被交互作用为主导,且50 %区块内因子交互作用存在非线性增强现象。③根据风险探测识别出不同功能区块高温风险区特征,商业服务区块、公共管理与商业服务混合（公-商）区块为城市高温风险较高的区域。基于用地功能区块的地理探测器模型对地表温度空间分异的解释优于市域水平的全局模型,可以较好地量化各因素在不同空间位置上对地表温度的影响,为制定分区域有针对性的城市热岛效应缓解策略提供参考。 相似文献
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Sliding mode control for uncertain discrete-time systems with Markovian jumping parameters and mixed delays 总被引：1，自引：0，他引：1
This paper is concerned with the robust sliding mode control (SMC) problem for a class of uncertain discrete-time Markovian jump systems with mixed delays. The mixed delays consist of both the discrete time-varying delays and the infinite distributed delays. The purpose of the addressed problem is to design a sliding mode controller such that, in the simultaneous presence of parameter uncertainties, Markovian jumping parameters and mixed time-delays, the state trajectories are driven onto the pre-defined sliding surface and the resulting sliding mode dynamics is stochastically stable in the mean-square sense. A discrete-time sliding surface is firstly constructed and an SMC law is synthesized to ensure the reaching condition. Moreover, by constructing a new Lyapunov–Krasovskii functional and employing the delay-fractioning approach, a sufficient condition is established to guarantee the stochastic stability of the sliding mode dynamics. Such a condition is characterized in terms of a set of matrix inequalities that can be easily solved by using the semi-definite programming method. A simulation example is given to illustrate the effectiveness and feasibility of the proposed design scheme. 相似文献
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Mirit Hen Maria Ronen Alex Deitch Efrat Barbiro-Michaely Ziv Oren Chaim N. Sukenik Doron Gerber 《Biomicrofluidics》2015,9(5)
Microfluidic-based protein arrays are promising tools for life sciences, with increased sensitivity and specificity. One of the drawbacks of this technology is the need to create fresh surface chemistry for protein immobilization at the beginning of each experiment. In this work, we attempted to include the process of surface functionalization as part of the fabrication of the device, which would substitute the time consuming step of surface functionalization at the beginning of each protein array experiment. To this end, we employed a novel surface modification using self-assembled monolayers (SAMs) to immobilize biomolecules within the channels of a polydimethylsiloxane (PDMS) integrated microfluidic device. As a model, we present a general method for depositing siloxane-anchored SAMs, with 1-undecyl-thioacetate-trichlorosilane (C11TA) on the silica surfaces. The process involved developing PDMS-compatible conditions for both SAM deposition and functional group activation. We successfully demonstrated the ability to produce, within an integrated microfluidic channel, a C11TA monolayer with a covalently conjugated antibody. The antibody could then bind its antigen with a high signal to background ratio. We further demonstrated that the antibody was still active after storage of the device for a week. Integration of the surface chemistry into the device as part of its fabrication process has potential to significantly simplify and shorten many experimental procedures involving microfluidic–based protein arrays. In turn, this will allow for broader dissemination of this important technology. 相似文献
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《Journal of The Franklin Institute》2023,360(2):1478-1493
This paper investigates stability of linear systems with multiple/single time-delays. Firstly, a three-level cascade augmented Lyapunov-Krasovskii (L-K) functional is introduced, in which interconnect information among delayed state vectors is fully taken into account. Based on a newly integral inequality and the cascade L-K functional, a novel stability criterion is derived for linear systems with multiple time-delays. Secondly, it is found that the proposed L-K functional is also suitable for linear systems with single time-delay if the delay-partitioning method is employed. This motivates us to obtain a less conservative stability condition for linear systems with single time-delay. Finally, Numerical examples are given to confirm the advantages of the proposed method. 相似文献
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目的:探讨使用常用皮肤消毒液(酒精、碘伏、安尔碘)时,蘸有消毒液的无菌棉签在皮肤上的涂擦力度、螺旋消毒方式,以及皮肤消毒面的干燥情况对皮肤消毒效果的影响,及使用常用皮肤消毒液2次涂擦消毒后,消毒处皮肤的干燥时间。方法:随机选取符合纳入标准的80名志愿者,随机分为A、B组各40名,A、B组均接受三种常用皮肤消毒液进行皮肤涂擦消毒,但涂擦力度、螺旋消毒方式、消毒面待干与否均有不同。结果:A、B组志愿者使用不同皮肤消毒液后,手背皮肤菌落数均减少,均可达到皮肤消毒效果标准要求。但只有使用碘伏和安尔碘消毒皮肤时涂擦力度不同,A、B组志愿者手背菌落数差异有统计学意义(P<0.05)。结论:三种皮肤消毒液均可达到良好的消毒效果;涂擦力度的轻重对消毒效果有影响,建议在临床实际中消毒皮肤时使用力度重的消毒手法,而螺旋消毒方式和消毒面待干与否对消毒效果无影响。 相似文献
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A new design method based on artificial bee colony algorithm for digital IIR filters 总被引：11，自引：0，他引：11
Nurhan Karaboga Author Vitae 《Journal of The Franklin Institute》2009,346(4):328-348
Digital filters can be broadly classified into two groups: recursive (infinite impulse response (IIR)) and non-recursive (finite impulse response (FIR)). An IIR filter can provide a much better performance than the FIR filter having the same number of coefficients. However, IIR filters might have a multi-modal error surface. Therefore, a reliable design method proposed for IIR filters must be based on a global search procedure. Artificial bee colony (ABC) algorithm has been recently introduced for global optimization. The ABC algorithm simulating the intelligent foraging behaviour of honey bee swarm is a simple, robust, and very flexible algorithm. In this work, a new method based on ABC algorithm for designing digital IIR filters is described and its performance is compared with that of a conventional optimization algorithm (LSQ-nonlin) and particle swarm optimization (PSO) algorithm. 相似文献
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《Journal of The Franklin Institute》2022,359(15):8084-8106
This paper’s primary motivation is to construct a class of novel terminal sliding-mode (TSM) control to stabilize systems rapidly with reduced chattering. To this end, a novel sliding surface, coined as practical TSM (PTSM) manifold, is designed with the help of the logarithmic hyperbolic cosine function. Since the partial flatness, i.e. the Lipschitz continuity and the practical terminal attractiveness, of the proposed PTSM manifold results in its derivative nonsingularity, the super-twisting algorithm (STA) is employed to generate its finite-time reachability with reduced chattering. Once the proposed sliding surface is established, controlled states will quickly fall into a small neighborhood of the equilibrium and then asymptotically slide to zero with a local high gain. In addition, this method is extended to solve the control problem of systems with mismatched uncertainties. Several groups of simulations verify the superiority of proposed controllers. 相似文献
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为了创建合理的结构模块,本文首先提出了功能元间相关性的指标层次模型;然后用功能元相对某一指标的相关度建立了功能模块划分方案的数学模型;接着用模糊树图法把相关度较高的功能元聚合为功能模块;最后介绍了如何从创建的功能模块得到合理结构模块的方法。经实例验证,用该方法能得到预期的结果。 相似文献
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This paper is concerned with the stability and stabilization for systems with two additive time-varying input delays arising from networked control systems. A new Lyapunov functional is constructed and a tighter upper bound of the derivative of the Lyapunov functional is derived by applying a convex polyhedron method. The resulting stability criteria are of fewer matrix variables and less conservative than some existing ones. Based on the stability criteria, a state feedback controller is designed such that the closed-loop system is asymptotically stable. Numerical examples are given to show the less conservatism of the stability criteria and the effectiveness of the designed method. 相似文献
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本文通过对功能材料教学中存在的问题分析,结合功能材料导论课程的特点及教学现状,提出了相应的教学内容与教学方法的改革与探索。教学实践表明,此教学方式能够弥补传统教学的不足,提高学生对功能材料学科的理解和认识,具有较好的教学效果,有利于培养学生的创新和买践能力。 相似文献
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This paper reviews our work on the application of ultrafast pulsed laser micro∕nanoprocessing for the three-dimensional (3D) biomimetic modification of materials surfaces. It is shown that the artificial surfaces obtained by femtosecond-laser processing of Si in reactive gas atmosphere exhibit roughness at both micro- and nanoscales that mimics the hierarchical morphology of natural surfaces. Along with the spatial control of the topology, defining surface chemistry provides materials exhibiting notable wetting characteristics which are potentially useful for open microfluidic applications. Depending on the functional coating deposited on the laser patterned 3D structures, we can achieve artificial surfaces that are (a) of extremely low surface energy, thus water-repellent and self-cleaned, and (b) responsive, i.e., showing the ability to change their surface energy in response to different external stimuli such as light, electric field, and pH. Moreover, the behavior of different kinds of cells cultured on laser engineered substrates of various wettabilities was investigated. Experiments showed that it is possible to preferentially tune cell adhesion and growth through choosing proper combinations of surface topography and chemistry. It is concluded that the laser textured 3D micro∕nano-Si surfaces with controllability of roughness ratio and surface chemistry can advantageously serve as a novel means to elucidate the 3D cell-scaffold interactions for tissue engineering applications. 相似文献
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Oliva Saldanha Martha E. Brennich Manfred Burghammer Harald Herrmann Sarah K?ster 《Biomicrofluidics》2016,10(2)
The structural organization of metazoan cells and their shape are established through the coordinated interaction of a composite network consisting of three individual filament systems, collectively termed the cytoskeleton. Specifically, microtubules and actin filaments, which assemble from monomeric globular proteins, provide polar structures that serve motor proteins as tracks. In contrast, intermediate filaments (IFs) assemble from highly charged, extended coiled coils in a hierarchical assembly mechanism of lateral and longitudinal interaction steps into non-polar structures. IF proteins are expressed in a distinctly tissue-specific way and thereby serve to generate the precise plasticity of the respective cells and tissues. Accordingly, in the cell, numerous parameters such as pH and salt concentration are adjusted such that the generation of functional networks is ensured. Here, we transfer the problem for the mesenchymal IF protein vimentin to an in vitro setting and combine small angle x-ray scattering with microfluidics and finite element method simulations. Our approach is adapted to resolve the early assembly steps, which take place in the sub-second to second range. In particular, we reveal the influence of ion species and concentrations on the assembly. By tuning the flow rates and thus concentration profiles, we find a minimal critical salt concentration for the initiation of the assembly. Furthermore, our analysis of the surface sensitive Porod regime in the x-ray data reveals that the formation of first assembly intermediates, so-called unit length filaments, is not a one-step reaction but consists of distinct consecutive lateral association steps followed by radial compaction as well as smoothening of the surface of the full-width filament. 相似文献
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Here, we present a simple chemical modification of poly(dimethylsiloxane) (PDMS) by curing a mixture of 2 wt% undecylenic acid (UDA) in PDMS prepolymer on a gold-coated glass slide. This gold slide had been previously pretreated with a self-assembled hydrophilic monolayer of 3-mercaptopropionic acid (MPA). During curing of the UDA∕PDMS prepolymer, the hydrophilic UDA carboxyl moieties diffuses toward the hydrophilic MPA carboxyl moieties on the gold surface. This diffusion of the UDA within the PDMS prepolymer to the surface is a direct result of surface energy minimization. Once completely cured, the PDMS is peeled off the gold substrate, thereby exposing the interfacial carboxyl groups. These groups are then available for subsequent attachment of 5(')-amino terminated DNA oligonucleotides via amide linkages. Our results show that the covalently tethered oligonucleotides can successfully capture fluorescein-labeled complementary oligonucleotides via hybridization, which are visualized using fluorescence microscopy. 相似文献