共查询到19条相似文献，搜索用时 515 毫秒
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蛋白质组学被认为是后基因组研究中的最主要的部分；介绍蛋白质组学主要相关技术；探讨蛋白质组学尤其是差异蛋白质组学的研究意义与特点；简要介绍该技术在植物胚胎发育研究上近期研究概况。 相似文献
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蛋白质组学以蛋白质组为研究对象，从整体蛋白质水平上更加深入、更加贴近生命本质的层次上去探索生命活动的规律以及重要的生理和病理等现象。文章对蛋白质组学的研究策略、范畴、主要研究内容和技术、蛋白质组信息学以及蛋白质组学发展趋势进行了介绍。 相似文献
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周卫东 《临沂师范学院学报》2005,27(3):46-48
蛋白质组学研究是近年来兴起的生命科学的前沿领域,是生命科学进入后基因组时代的标志之一.简要介绍了蛋白质组和蛋白质组学的概念、产生背景,阐述了蛋白质组学的研究内容、方法和研究意义,并展望了其发展前景. 相似文献
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蛋白质芯片技术是一种快速、高效、高通量、微型化和自动化的蛋白质分析技术。目前，它已成为肿瘤蛋白质组学研究的重要工具之一。它能洞察肿瘤细胞、组织和生物体蛋白质含量的细微变化，且能精确分析某一特定蛋白质的理化性质。就近年来蛋白质芯片的发展及其在肿瘤蛋白质组学研究中的应用做了简要的叙述，提出了该技术存在的问题，并对其发展前景进行了展望。 相似文献
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蛋白质组学研究进展及展望 总被引：5，自引：0，他引：5
蛋白质组从蛋白质整体水平上研究其作用模式、功能机理、调节调控以及蛋白质组群内的相互作用，从而为临床诊断、病理研究、药物筛选、新药开发、新陈代谢途径研究等提供理论依据和基础。蛋白质组的研究手段主要有2DE、质谱技术以及研究蛋白质之间相互作用的酵母双杂交、表面等离子技术等。本简单地回顾了近年来蛋白质组学研究的一些成果及该领域近年来的发展动态。 相似文献
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Urine has become one of the most attractive biofluids in clinical proteomics,for its procurement is easy and noninvasive and it contains sufficient proteins and peptides. Urinary proteomics has thus rapidly developed and has been extensively applied to biomarker discovery in clinical diseases,especially kidney diseases. In this review,we discuss two important aspects of urinary proteomics in detail,namely,sample preparation and proteomic tech-nologies. In addition,data mining in urinary proteomics is also b... 相似文献
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Conidial fungi or molds and mildews are widely used in modern biotechnology as producers of antibiotics and other secondary metabolites,industrially important enzymes,chemicals and food.They are also important pathogens of animals including humans and agricultural crops.These various applications and extremely versatile natural phenotypes have led to the constantly growing list of complete genomes which are now available.Functional genomics and proteomics widely exploit the genomic information to study the ... 相似文献
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Alejandra J. Magana Manaz Taleyarkhan Daniela Rivera Alvarado Michael Kane John Springer Kari Clase 《CBE life sciences education》2014,13(4):607-623
Bioinformatics education can be broadly defined as the teaching and learning of the use of computer and information technology, along with mathematical and statistical analysis for gathering, storing, analyzing, interpreting, and integrating data to solve biological problems. The recent surge of genomics, proteomics, and structural biology in the potential advancement of research and development in complex biomedical systems has created a need for an educated workforce in bioinformatics. However, effectively integrating bioinformatics education through formal and informal educational settings has been a challenge due in part to its cross-disciplinary nature. In this article, we seek to provide an overview of the state of bioinformatics education. This article identifies: 1) current approaches of bioinformatics education at the undergraduate and graduate levels; 2) the most common concepts and skills being taught in bioinformatics education; 3) pedagogical approaches and methods of delivery for conveying bioinformatics concepts and skills; and 4) assessment results on the impact of these programs, approaches, and methods in students’ attitudes or learning. Based on these findings, it is our goal to describe the landscape of scholarly work in this area and, as a result, identify opportunities and challenges in bioinformatics education. 相似文献
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Tania C. Ara��jo-Jorge Tania S. Cardona Cl��udia L. S. Mendes Andrea Henriques-Pons Rosane M. S. Meirelles Cl��udia M. L. M. Coutinho Luiz Edmundo V. Aguiar Maria de Nazareth L. Meirelles Solange L. de Castro Helene S. Barbosa Mauricio R. M. P. Luz 《CBE life sciences education》2004,3(2):99-110
The advent of genomics, proteomics, and microarray technology has brought much
excitement to science, both in teaching and in learning. The public is eager to
know about the processes of life. In the present context of the explosive growth
of scientific information, a major challenge of modern cell biology is to
popularize basic concepts of structures and functions of living cells, to
introduce people to the scientific method, to stimulate inquiry, and to analyze
and synthesize concepts and paradigms. In this essay we present our experience
in mixing science and education in Brazil. For two decades we have developed
activities for the science education of teachers and undergraduate students,
using microscopy images generated by our work as cell biologists. We describe
open-air outreach education activities, games, cell modeling, and other
practical and innovative activities presented in public squares and
favelas. Especially in developing countries, science education is
important, since it may lead to an improvement in quality of life while
advancing understanding of traditional scientific ideas. We show that teaching
and research can be mutually beneficial rather than competing pursuits in
advancing these goals. 相似文献
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随着后基因时代的到来,“组学”成为了生命科学领域研究的新热点,其在中医药领域也得到了广泛应用。本文就基因组学、蛋白质组学、代谢组学等“组学”技术在中医证候及中药作用机制研究中的应用进行综述。 相似文献
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本文研究的主要目的是建立大肠杆菌可溶性蛋白质组的双向电泳技术,以等点聚焦为第一向,SDS—PAGE为第二向进行双向电泳,并对样品处理方式、蛋白上样量和染色方法等关键因素和环节进行了比较研究,通过实验条件的筛选和优化获得了较满意的双向电泳图谱。采取的方法具有较高的分辨率和重复性,为进一步研究其蛋白质组学奠定了基础,成功地用于了本科实验教学中。 相似文献
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训诂学和汉语史都是以历代流传下来的文献语言材料作为依据的。随文释义的注释材料、纂集类训诂专书和考证材料是研究汉语史的极其重要的材料。训诂材料在汉语词汇史研究中的价值最大, 在汉语语音史和汉语语法史研究中的价值也不可估量。我们应该将汉语史研究和训诂学研究有机结合起来, 充分发挥训诂材料在汉语史研究中的作用。 相似文献