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1.
This article investigated how mathematic anxiety (MA) of Korean middle school students could be reduced by comparing analytically their cognitive neuroscience and questionnaire results. We developed a three-hour Complex Treatment Program (CTP) on quadratic functions for the study. In the summer of 2016, we collected data of the pre and post MA questionnaires by Mathematics Anxiety Scale for Students (MASS), the percent of correct answers (PCA) and reaction time (RT) by E-prime program, and also brain-imaging data of the event related potentials (ERP) by Electroencephalograph (EEG) using computer-based functional F-G model. The result indicated the CTP to be effective with the group with higher math anxiety and the group with higher achievement respectively. The MASS result was verified with the better performance of PCA on type G, which was measured by E-prime program. Some interesting patterns were revealed on brain-imaging data by EEG, indicating more brain activities with the MA groups.  相似文献   

2.
Using time‐frequency analysis techniques to investigate the event‐related low‐frequency (delta: 0.5–4 Hz; theta: 4–8 Hz) activity of auditory event‐related potentials (ERPs) data of highly and average intelligent children, 18 intellectually gifted children, and 18 intellectually average children participated the present study. Present findings show that intellectually gifted children had significantly larger delta activity than their normal peers in mismatch negativity (MMN) component, while in P3a component, which originates from stimulus‐driven frontal attention mechanisms during task processing, intellectually gifted children had both significantly larger delta and theta activities than their normal peers. The present findings further supported that low‐frequency brain activity could be regarded as the basis of intelligence and cognitive functions, and spectral EEG time‐frequency analysis technique should be used to explore some new aspects of brain activity relating to intelligence.  相似文献   

3.
To investigate inter- and intra-hemispheric electroencephalography (EEG) coherence at rest and during photic stimulation of patients with Alzheimer‘s disease (AD). Thirty-five patients (12 males, 23 females; 52-64 y) and 33 sex- and age-matched controls (12 males, 21 females; 56-65 y) were recruited in the present study. EEG signals from C3-C4, P3-P4, TS-T6 and O1-O2 electrode pairs resulted from the inter-hemispheric action, and EEG signals from C3-P3, C4-P4, P3-O1, P4-O2, C3-O1, C4-O2, TS-O1 and T6-O2 electrode pairs resulted from the intra-hemispheric action. The influence of inter- and intra-hemispheric coherence on EEG activity with eyes closed was examined, using fast Fourier transformation from the 16 sampled channels. The frequencies of photic stimulation were fixed at 5, l0 and 15 Hz, respectively. The general decrease of AD patients in inter- and intra-hemispheric EEG coherence was more significant than that of the normal controls at the resting EEG, with most striking decrease observed in the alpha-1 (8.0-9.0 Hz) and alpha-2 (9.5-12.5 Hz) bands. During photic stimulation, inter- and intra-hemispheric EEG coherences of the AD patients having lower values in the alpha (9.5-10.5 Hz) band than those of the control group. It suggests that under stimulated and non-stimulated conditions, AD patients had impaired inter- and intra-hemispheric functional connections, indicating failure of brain activation in alpha-related frequency.  相似文献   

4.
Obtaining an electrocorticograms （ECoG） signal requires an invasive procedure in which brain activity is recorded from the cortical surface. In contrast, obtaining electroencephalograms （EEG） recordings requires the non-invasive procedure of recording the brain activity from the scalp surface, which allows EEG recordings to be performed more easily on healthy humans. In this work, a technique previously used to study spatial-temporal patterns of brain activity on animal ECoG was adapted for use on EEG. The main issues are centered on solving the problems introduced by the increment on the interelectrode distance and the procedure to detect stable frames. The results showed that spatial patterns of beta and gamma activity can also be extracted from the EEG signal by using stable frames as time markers for feature extraction. This adapted technique makes it possible to take advantage of the cognitive and phenomenological awareness of a normal healthy subject.  相似文献   

5.
语言理解的ERP 研究   总被引：7，自引：1，他引：7  
伴随着实时研究方法和技术的发展，上世纪80年代中期之后，事件相关脑电位(ERP)作为一种比反应时更精细和敏感的指标在心理学研究领域中得到大量运用。在语言理解领域，目前已发现了三种不同的ERP成分，分别是反映词汇一语义加工的N400、反映实时句法加工的ELAN／LAN和后期整合的P600，这三种成分在正常人和失语症病人之间有着不同的表现形态。在未来，ERP和其他相关技术的结合将有利于语言理解的更深入研究。  相似文献   

6.
To investigate the features of electroencephalography (EEG) power and coherence at rest and during a working memory task of patients with mild cognitive impairment (MCI). Thirty-five patients (17 males, 18 females; 52～71 years old) and 34 sex- and age-matched controls (17 males, 17 females; 51～63 years old) were recruited in the present study. Mini-Mental State Examination (MMSE) of 35 patients with MCI and 34 normal controls revealed that the scores of MCI patients did not differ significantly from those of normal controls (P＞0.05). Then, EEGs at rest and during working memory task with three levels of working memory load were recorded. The EEG power was computed over 10 channels: right and left frontal (F3, F4), central (C3,C4), parietal (P3, P4), temporal (TS, T6) and occipital (O1, O2); inter-hemispheric coherences were computed from five electrode pairs of F3-F4, C3-C4, P3-P4, T5-T6 and O1-O2 for delta (1.0～3.5 Hz), theta (4.0～7.5 Hz), alpha-1 (8.0～10.0 Hz), alpha-2 (10.5～13.0 Hz), beta-1 (13.5～18.0 Hz) and beta-2 (18.5～30.0 Hz) frequency bands. All values of the EEG power of MCI patients were found to be higher than those of normal controls at rest and during working memory tasks. Furthermore, the values of EEG power in the theta, alpha-1, alpha-2 and beta-1 bands of patients with MCI were significantly high (P＜0.05) in comparison with those of normal controls. Correlation analysis indicated a significant negative correlation between the EEG powers and MMSE scores. In addition, during working memory tasks, the EEG coherences in all bands were significantly higher in the MCI group in comparison with those in the control group (P＜0.05). However, there was no significant difference in EEG coherences between two groups at rest. These findings comprise evidence that MCI patients have higher EEG power at rest, and higher EEG power and coherence during working conditions. It suggests that MCI may be associated with compensatory processes at rest and during working memory tasks. Moreover, failure of normal cortical connections may be exist in MCI patients.  相似文献   

7.
目的:探讨磁共振成像(MRI)和经颅多普勒(TCD)评价后循环缺血的价值。方法:对56例诊断为后循环缺血患者的临床资料进行回顾性分析。结果:头颅MRI发现脑干、小脑、枕叶梗死灶共46个;椎基底动脉磁共振血管造影显示达39例(69.6%)双侧椎动脉不对称、粗细不均,10例(17.9%)一侧椎动脉起始段不同程度狭窄,1例锁骨下动脉狭窄。TCD显示血流速度异常者40例(71.4%),频谱异常36例(64.3%)。结论:MRI和TCD能给后循环缺血的诊断提供客观依据;MRI优于TCD。  相似文献   

8.
Objective： To assess functional relationship by calculating inter- and intra-hemispheric electroencephalography （EEG） coherence at rest and during a working memory task of patients with mild cognitive impairment （MCI）. Methods： The sample consisted of 69 subjects： 35 patients （n = 17 males, n = 18 females; 52-71 years old） and 34 normal controls （n = 17 males, n = 17 females; 51 -63 years old）. Mini-mental state examination （MMSE） of two groups revealed that the scores of MCI patients did not differ significantly from those of normal controls （P〉0.05）. In EEG recording, subjects were performed at rest and during working memory task. EEG signals from F3-F4, C3-C4, P3-P4, T5-T6 and O1-O2 electrode pairs are resulted from the inter-hemispheric action, and EEG signals from F3-C3, F4-C4, C3-P3, C4-P4, P3-O1, P4-O2, T5-C3, T6-C4, T5-P3 and T6-P4 electrode pairs are resulted from the intra-hemispheric action for delta （1.0-3.5 Hz）, theta （4.0-7.5 Hz）, alpha-1 （8.0-10.0 Hz）, alpha-2 （10.5-13.0 Hz）, beta-1 （13.5-18.0 Hz） and beta-2 （18.5-30.0 Hz） frequency bands. The influence of inter- and intra-hemispheric coherence on EEG activity with eyes closed was examined using fast Fourier transformation from the 16 sampled channels. Results： During working memory tasks, the inter- and intra-hemispheric EEG coherences in all bands were significantly higher in the MCI group in comparison with those in the control group （P〈0.05）. However, there was no significant difference in inter- and intra-hemispheric EEG coherences between two groups at rest. Conclusion： Experimental results comprise evidence that MCI patients have higher degree of functional connectivity between hemispheres and in hemispheres during working condition, It suggests that MCI may be associated with compensatory processes during working memory tasks between hemispheres and in hemispheres. Moreover, failure of normal cortical connections may exist in MCI patients.  相似文献   

9.
In this study, the inhibitory effect ofjujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG (electroencephalogram) and the concentration of hippocampal Glutamate (Glu) were monitored simultaneously in vivo as indicators of rat's excitatory state. Power spectral density (PSD) and gravity frequency of PSD were calculated. JuA (0.05 g/L and 0.1 g/L) inhibited the EEG excitation effect caused by Na-PCN by increasing the power of δ1 and δ2bands (P＜0.01 vs model) and lowering the gravity frequency of PSD (P＜0.01 vs model). JuA also remarkably reduced the Glu elevation induced by Na-PCN (P＜0.05 vs model). Diazepam also depressed Glu concentration and lowered the gravity frequency,but it showed a different EEG pattern in increased β2-activity (P＜0.01 vs model). EEG excitation caused by Na-PCN correlated with Glu elevation during the first hour. Neurophysiological inhibitory effects of JuA and diazepam were more persistent than their Glu inhibitoty effects.  相似文献   

10.
We described a female patient with insulinoma who experienced recurrent episodes of automatism, confusion and convulsion. Furthermore, her electroencephalography (EEG) findings resembled the pattern in complex partial seizures with secondary generalization. The interictal EEG showed spikes and sharp waves, as well as focal slowing over the left temporal lobe, and the ictal EEG revealed generalized spikes and sharp waves associated with diffused slowing. She was initially misdiagnosed as pharmacoresistant epilepsy. After the insulinoma was found and surgically removed, her EEG turned normal and she was seizure-free during the 4-year follow-up. This report highlights the need for careful reassessment of all seizures refractory to medication, even for the patients associated with epileptiform discharges on EEG.  相似文献   

11.
Distance effect has been regarded as the best established marker of basic numerical magnitude processes and is related to individual mathematical abilities. A larger behavioral distance effect is suggested to be concomitant with lower mathematical achievement in children. However, the relationship between distance effect and superior mathematical abilities is unclear. One could get superior mathematical abilities by acquiring the skill of abacus-based mental calculation (AMC), which can be used to solve calculation problems with exceptional speed and high accuracy. In the current study, we explore the relationship between distance effect and superior mathematical abilities by examining whether and how the AMC training modifies numerical magnitude processing. Thus, mathematical competencies were tested in 18 abacus-trained children (who accepted the AMC training) and 18 non-trained children. Electroencephalography (EEG) waveforms were recorded when these children executed numerical comparison tasks in both Arabic digit and dot array forms. We found that: (a) the abacus-trained group had superior mathematical abilities than their peers; (b) distance effects were found both in behavioral results and on EEG waveforms; (c) the distance effect size of the average amplitude on the late negative-going component was different between groups in the digit task, with a larger effect size for abacus-trained children; (d) both the behavioral and EEG distance effects were modulated by the notation. These results revealed that the neural substrates of magnitude processing were modified by AMC training, and suggested that the mechanism of the representation of numerical magnitude for children with superior mathematical abilities was different from their peers. In addition, the results provide evidence for a view of non-abstract numerical representation.  相似文献   

12.
Magnetic stimulationis used to excitetissue in the hu-man nervoussystempainlesslyand noninvasively,andis al-so atool forinvestigatingbrainfunction[1—11].Usually,themagnetic stimulator has one circular coil or afigure-of-eightcoil ,and the coil needs to b…  相似文献   

13.
In recent years, there has been a growing interest in white matter anatomy of the human brain. With advances in brain imaging techniques, the significance of white matter integrity for brain function has been demonstrated in various neurological and psychiatric disorders. As the demand for interpretation of clinical and imaging data on white matter increases, the needs for white matter anatomy education are changing. Because cross‐sectional images and formalin‐fixed brain specimens are often insufficient in visualizing the complexity of three‐dimensional (3D) white matter anatomy, obtaining a comprehensible conception of fiber tract morphology can be difficult. Fiber dissection is a technique that allows isolation of whole fiber pathways, revealing 3D structural and functional relationships of white matter in the human brain. In this study, we describe the use of fiber dissection in combination with plastination to obtain durable and easy to use 3D white matter specimens that do not require special care or conditions. The specimens can be used as a tool in teaching white matter anatomy and structural connectivity. We included four human brains and show a series of white matter specimens of both cerebrum and cerebellum focusing on the cerebellar nuclei and associated white matter tracts, as these are especially difficult to visualize in two‐dimensional specimens and demonstrate preservation of detailed human anatomy. Finally, we describe how the integration of white matter specimens with radiological information of new brain imaging techniques such as diffusion tensor imaging tractography can be used in teaching modern neuroanatomy with emphasis on structural connectivity. Anat Sci Educ. 7: 47–55. © 2013 American Association of Anatomists.  相似文献   

14.
目的:探讨大鼠脑弥漫性轴索损伤(DAI)后早期轴索病理学改变及c-Fos蛋白的变化,为DAI的早期法医病理学鉴定寻找新的依据.方法:参照Mamarou的打击负荷伤模型,建立大鼠DAI动物模型.运用神经纤维特殊染色法观察轴索的病理学改变,并运用免疫组化SABC法观察c-Fos的变化.结果:嗜银染色于打击后1 h即可观察到...  相似文献   

15.
Objective: To study the relationships among magnetic resonance imaging (MRI), histological findings, and insulin-like growth factor-I (IGF-I) in steroid-induced osteonecrosis of the femoral head in rabbits. Methods: Thirty rabbits were randomly divided into experimental Group A (n=15) and control Group B (n=15). The 7.5 mg/kg (2 ml) ofdexamethasone (DEX)and physiological saline (2 ml) were injected into the fight gluteus medius muscle twice at one-week intervals in animals of Groups A and B, respectively. At 4, 8 and 16 weeks after obtaining an MRI, the rabbits were sacrificed and the femoral head from one side was removed for histological study of lacunae empty of osteocytes, subchondral vessels, and size of fat cells under microscopy, and the femoral head from the other side was removed for enzyme-linked immunoadsorbent assay (ELISA) for IGF-I.Results: At 4, 8 and 16 weeks after treatment, no necrotic lesions were detected in Group B, while they were detected in Group A.Light microscopy revealed that the fat cells of the marrow cavity were enlarged, subchondral vessels were evidently decreased,and empty bone lacunae were clearly increased. The IGF-I levels in Group A were significantly higher than those in Group B. At 8 weeks after the DEX injection, the MRI of all 20 femora showed an inhomogeneous, low signal intensity area in the femoral head,and at 16 weeks, the findings of all 10 femora showed a specific "line-like sign". The MRI findings of all femora in Group B were normal. Conclusion: MRI is a highly sensitive means of diagnosing early experimental osteonecrosis of the femoral head. However, the abnormal marrow tissues appeared later than 4 weeks when the expression of IGF-I increased. This reparative factor has an early and important role in response to steroid-induced osteonecrosis of the femoral head, and provides a theoretical foundation for understanding the pathology and designing new therapies.  相似文献   

16.
The efficiency of chlorine and chloramines disinfection on biofilm development in a simulated drinking water distribution system was investigated by using heterotrophic bacterial spread plate technique. The experiments were carried out with four annular reactors （ARs） with stainless steel （SS） or copper （Cu） material slides. The results showed that there were fewer bacteria attached to Cu slides without a disinfectant compared with those attached to SS slides. When the water was disinfected with chloramines, the heterotrophic plate counts （HPCs） on the biofilm attached to the Cu slides were significantly lower （by 3.46 log CFU/cm^2） than those attached to the SS slides. Likewise, the biofilm HPC numbers on the Cu slides were slightly lower （by 1.19 log CFU/cm^2） than those on the SS slides disinfected with chlorine. In a quasi-steady state, the HPC levels on Cu slides can be reduced to 3.0 log CFU/cm^2 with chlorine and to about 0.9 log CFU/cm^2 with chloramines. The addition of chloramines resulted in a more efficient reduction of biofilm heterotrophic bacteria than did chlorine. We concluded that the chlorine and chloramines levels usually employed in water distribution system were not sufficient to prevent the growth and development of microbial biofilm. The combination of copper pipe slides and chloramines as the disinfectant was the most efficient combination to bring about diminished bacterial levels.  相似文献   

17.
选取没有音乐训练经验的8名本科生被试借助计算机进行实验,用16导脑电地形图仪记录被试脑电功率的变化,探索三种不同速度音乐感知过程中的脑电波谱功率的差异。结果表明:在音乐欣赏状态下,大脑听觉区以α波段活动为主;在欣赏不同速度的乐曲时,脑电波谱功率发生了明显变化,特别是在α波段慢速音乐诱发的平均功率值和峰频功率均高于中速和快速,且α波段不同乐速的峰频变化明显;由于大脑两侧的不对称性,T5的频段内平均功率、总功率、频谱功率、峰频功率显著小于T6的。由此,不同速度的乐曲会引起脑电功率的不同变化。  相似文献   

18.
Study on the neurotoxic effects of low-level lead exposure in rats   总被引：10，自引：0，他引：10  
Objective: To investigate effects of developmental lead exposure on nitric oxide synthase (NOS) activity in different brain regions and on N-methyl-D-aspartate (NMDA) receptor mRNA expression in the hippocampus of rats. On the basis of these observations, we explored possible mechanisms by which lead exposure leads to impaired learning and memorizing abilities in children. Methods: A series of rat animal models exposed to low levels of lead during the developing period was established (drinking water containing 0.025%, 0.05% and 0.075% lead acetate). NOS activities in the hippocampus, the cerebral cortex, the cerebellum and the brain stem were determined with fluorescence measurement and levels of mRNA expression of the NMDA receptor 2A (NR2A) subunit and NMDA receptor 2B (NR2B) subunit in the rat hippocampus were measured with Retro-translation (RT-PCR). Results: There were no differences in the body weight of rat pups between any of the groups at any given time (P>0.05). The blood lead level of Pb-exposed rat pups showed a systematic pattern of change: at 14 d of age, it was lower than that at 7 d of age, then rising to the peak level at 21 d and finally falling to lower levels at 28 d. The hippocampal NOS activities of lead-exposed groups were all lower than that of the control group on the 21st and 28th day (P<0.01). NOS activities in the cerebellum of lead-exposed groups were all lower than that of the control group on the 21st and 28th day (P<0.001) and the NOS activity of the 0.025% group was significantly lower than that of the 0.05% and 0.075% groups on the 28th day (P<0.05). NOS activity in the cerebral cortex of the 0.075% group was significantly lower than that of the control, 0.025% and 0.05% groups on the four day spans (P<0.001). There was no significant difference of NOS activity in the brain stem between any lead-exposed group and the control group on the four day spans. In the 0.05% and the 0.075% groups, the level of NR2A mRNA expression was higher than that in the control group at 7 d and 14 d of age (P<0.05). In the 0.025% group, the level of NR2A was found to be higher than that in the control group at 7 d of age only (P<0.05). No significant differences were found for the levels of NR2B mRNA expression between any of the groups at any given time. Conclusions: NOS activity in the hippocampus, the cerebral cortex and the cerebellum are inhibited by lead exposure. The degree of the inhibitory effect depends on the time span of exposure and the lead concentration. Developmental low-level lead exposure was found to raise the level of NR2A mRNA expression in the hippocampus of rats. Developmental low-level lead exposure does not affect the level of NR2B mRNA expression in the hippocampus.  相似文献   

19.
ABSTRACT— Although many articles have addressed the relationship of neuroscience and education at a theoretical level, none has considered as a practical matter how one integrates neuroscientific data into a behavioral theory that uses hypothetical constructs. We describe 4 techniques by which researchers may do so: (a) direct observation of hypothetical constructs in the brain, (b) validation of hypothetical constructs through brain imaging, (c) using neural architecture to infer a behavioral architecture, and (d) using well-developed knowledge of brain function to select among competing behavioral theories. A detailed examination of these 4 techniques indicates that they are amenable to educational research and, indeed, have been used to inform research and theory. We argue that these techniques are not applicable to all educational research problems, but rather they are appropriate to relatively low-level behaviors (e.g., reading) rather than complex behaviors (e.g., classroom management).  相似文献   

20.
In order to sufficiently exploit the advantages of different signal processing methods, such as wavelet transformation (WT), artificial neural networks (ANN) and expert rules (ER), a synthesized multi-method was introduced to detect and classify the epileptic waves in the EEG data. Using this method, at first, the epileptic waves were detected from pre-processed EEG data at different scales by WT, then the characteristic parameters of the chosen candidates of epileptic waves were extracted and sent into the well-trained ANN to identify and classify the true epileptic waves,and at last, the detected epileptic waves were certificated by ER. The statistic results of detection and classification show that, the synthesized multi-method has a good capacity to extract signal features and to shield the signals from the random noise. This method is especially fit for the analysis of the biomedical signals in biomedical engineering which are usually non-placid and nonlinear.  相似文献   

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