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1.
A procedure is presented whereby the control volume equations for one-dimensional, compressible gas dynamics are cast into first-order, state variable form. These equations are interpreted using causal bond graphs. The resulting bond graph is shown to reduce to the classic I-C chain under acoustic constraints and to a more recently developed model of low speed thermal energy transport subject to associated constraints.Through example it is demonstrated that the control volume bond graph is easily coupled to an overall system model and thus can be digitally simulated as part of the overall nonlinear state space representation. The result is that a very accurate gas dynamic model can be coupled with an overall dynamic system model without requiring a prohibitively large number of equations.  相似文献   

2.
How can the development and commercialization of university-based technology be managed more effectively? In approaching this question, the paper utilizes organizational control theory (OCT) to analyze the effects of organizational controls on performance at each stage of a generic university-industry technology transfer (UITT) process. The paper contributes to the literature by providing a conceptual framework that is useful for explaining major issues found in the largely empirical literature on UITT. The analysis also elucidates the most effective controls, which vary across stages. As such, the paper also contributes to the literature by taking a longitudinal perspective on OCT in the UITT process. Managers and researchers of UITT may benefit from utilizing an organizational controls perspective when managing and studying the UITT phenomenon. Managerial and research implications are discussed in order to improve UITT management and drive future conceptually-grounded research in the area.  相似文献   

3.
This study addresses the usage of different features to complement synset-based and bag-of-words representations of texts in the context of using classical ML approaches for spam filtering (Ferrara, 2019). Despite the existence of a large number of complementary features, in order to improve the applicability of this study, we have selected only those that can be computed regardless of the communication channel used to distribute content. Feature evaluation has been performed using content distributed through different channels (social networks and email) and classifiers (Adaboost, Flexible Bayes, Naïve Bayes, Random Forests, and SVMs). The results have revealed the usefulness of detecting some non-textual entities (such as URLs, Uniform Resource Locators) in the addressed distribution channels. Moreover, we also found that compression properties and/or information regarding the probability of correctly guessing the language of target texts could be successfully used to improve the classification in a wide range of situations. Finally, we have also detected features that are influenced by specific fashions and habits of users of certain Internet services (e.g. the existence of words written in capital letters) that are not useful for spam filtering.  相似文献   

4.
The properties of a cell’s microenvironment are one of the main driving forces in cellular fate processes and phenotype expression invivo. The ability to create controlled cell microenvironments invitro becomes increasingly important for studying or controlling phenotype expression in tissue engineering and drug discovery applications. This includes the capability to modify material surface properties within well-defined liquid environments in cell culture systems. One successful approach to mimic extra cellular matrix is with porous electrospun polymer fiber scaffolds, while microfluidic networks have been shown to efficiently generate spatially and temporally defined liquid microenvironments. Here, a method to integrate electrospun fibers with microfluidic networks was developed in order to form complex cell microenvironments with the capability to vary relevant parameters. Spatially defined regions of electrospun fibers of both aligned and random orientation were patterned on glass substrates that were irreversibly bonded to microfluidic networks produced in poly-dimethyl-siloxane. Concentration gradients obtained in the fiber containing channels were characterized experimentally and compared with values obtained by computational fluid dynamic simulations. Velocity and shear stress profiles, as well as vortex formation, were calculated to evaluate the influence of fiber pads on fluidic properties. The suitability of the system to support cell attachment and growth was demonstrated with a fibroblast cell line. The potential of the platform was further verified by a functional investigation of neural stem cell alignment in response to orientation of electrospun fibers versus a microfluidic generated chemoattractant gradient of stromal cell-derived factor 1 alpha. The described method is a competitive strategy to create complex microenvironments invitro that allow detailed studies on the interplay of topography, substrate surface properties, and soluble microenvironment on cellular fate processes.  相似文献   

5.
The binary matrices A which are circulant with one or more of the following properties: (1) A is symmetric, i.e. A = AT, (2) A is orthogonal, i.e. AAT = I (mod 2), (3) A has low multiplicative order, i.e. Am = I, occur often in communication, control and network theory problems. In this paper we construct a number of such matrices. The results are based on the theory of power-residues modulo an odd prime p, and the fact that the algebra of all p × p circulant matrices is isomorphic to the algebra of polynomials modulo (xp?1).  相似文献   

6.
These are indeed exceptional and historic times, a global pandemic and public health emergency sitting side by side with heightened public awareness of the injustices of decades of institutional racism. This article considers the current pandemic and lockdown period through a VUCA lens and offers reflection on how the pandemic revealed the fragility of digitally immature organisations. VUCA, a managerial catchall acronym for Volatility, Uncertainty, Complexity and Ambiguity is a litmus test for recognising unpredictable external environments. We offer business leaders a caveat, it is dangerous to ignore the impact of VUCA on the smooth functioning of an organisation. In terms of digital transformation during lockdown this article offers three key lessons that can so far be discerned from the pandemic period, firstly organisations must improve their digital maturity, secondly, less digitally mature organisations are more fragile and finally organisations with higher levels of digital maturity are generally more flexible.  相似文献   

7.
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8.
BackgroundReconstruction of customized cranial implants with a mesh structure using computer-assisted design and additive manufacturing improves the implant design, surgical planning, defect evaluation, implant-tissue interaction and surgeon's accuracy. The objective of this study is to design, develop and fabricate cranial implant with mechanical properties closer to that of bone and drastically decreases the implant failure and to improve the esthetic outcome in cranial surgery with precision fitting for a better quality of life. A customized cranial mesh implant is designed digitally, based on the Digital Imaging and Communication in Medicine files and fabricated using state of the Art-Electron Beam Melting an Additive Manufacturing technology. The EBM produced titanium implant was evaluated based on their mechanical strength and structural characterization.ResultsThe result shows, the produced mesh implants have a high permeability of bone ingrowth with its reduced weight and modulus of elasticity closer to that the natural bone thus reducing the stress shielding effect. Scanning electron microscope and micro-computed tomography (CT) scanning confirms, that the produced cranial implant has a highly regular pattern of the porous structure with interconnected channels without any internal defect and voids.ConclusionsThe study reveals that the use of mesh implants in cranial reconstruction satisfies the need of lighter implants with an adequate mechanical strength, thus restoring better functionality and esthetic outcomes for the patients.  相似文献   

9.
In this paper two robust controllers for a multivariable vertical short take-off and landing (VSTOL) aircraft system are designed and compared. The aim of these controllers is to achieve robust stability margins and good performance in step response of the system. LQG/LTR method is a systematic design approach based on shaping and recovering open-loop singular values while mixed-sensitivity H∞ method is established by defining appropriate weighting functions to achieve good performance and robustness. Comparison of the two controllers show that LQG method requires rate feedback to increase damping of closed-loop system, while H∞ controller by only proper choose the weighting functions, meets the same performance for step response. Output robustness of both controllers is good but H∞ controller has poor input stability margin. The net controller order of H∞ is higher than the LQG/LTR method and the control effort of them is in the acceptable range.  相似文献   

10.
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11.
Red blood cells (RBCs) are important to dictate hemorheological properties of blood. The shear-thinning effect of blood is mainly attributed to the characteristics of the RBCs. Variations in hemorheological properties alter flow resistance and wall shear stress in blood vessels. Therefore, detailed understanding of the relationship between the hemorheological and hemodynamic properties is of great importance. In this study, blood viscosity and blood flow were simultaneously measured in the same microfluidic device by monitoring the flow-switching phenomenon. To investigate blood flows according to hemorheological variations, the flow rate of blood samples (RBCs suspended in autologous plasma, dextran-treated plasma, and in phosphate buffered saline solution) was precisely controlled with a syringe pump. Velocity profiles of blood flows were measured by using a micro-particle image velocimetry technique. The shape of velocity profiles was quantified by using a curve-fitting equation. It is found that the shape of the velocity profiles is highly correlated with blood viscosity. To demonstrate the relationship under ex vivo conditions, biophysical properties and velocity profiles were measured in an extracorporeal rat bypass loop. Experimental results show that increased blood viscosity seems to induce blunt velocity profile with high velocity component at the wall of the microchannel. Simultaneous measurement of blood viscosity and velocity profile would be useful for understanding the effects of hemorheological features on the hemodynamic characteristics in capillary blood vessels.  相似文献   

12.
Multiple sample DNA amplification was done by using a novel rotary-linear motion polymerase chain reaction (PCR) device. A simple compact disc was used to create the stationary sample chambers which are individually temperature controlled. The PCR was performed by shuttling the samples to different temperature zones by using a combined rotary-linear movement of the disc. The device was successfully used to amplify up to 12 samples in less than 30 min with a sample volume of 5 μl. A simple spring loaded heater mechanism was introduced to enable good thermal contact between the samples and the heaters. Each of the heater temperatures are controlled by using a simple proportional–integral–derivative pulse width modulation control system. The results show a good improvement in the amplification rate and duration of the samples. The reagent volume used was reduced to nearly 25% of that used in conventional method.  相似文献   

13.
Carboplatin is a chemotherapeutic agent used against various malignancies such as ovarian carcinoma. The aim of this study is to improve the therapeutic efficacy of carboplatin using pegylated liposomal nanocarriers. Nanoparticles were synthesized using thin film hydration technique and characterized for shape morphology, particle size, zeta potential and drug-release properties. In the next step, A2780S and A2780CP ovarian cancer cell lines were used to determine the efficacy of nanodrug by MTT assay. The particle size and zeta potential of nanodrug were measured 244.3 ± 19.6 nm and ?22.9 ± 1.7 mV, respectively. High encapsulation capacity (78.6 ± 3.7 %) confirmed the efficiency of technique. The cytotoxicity results also showed that nanodrug compared to free drug improve the efficacy of carboplatin against both A2780S (P < 0.01) and A2780CP (P < 0.05) cell lines. In conclusion, the findings of our study suggested pegylated liposomal nanocarriers are proper for carboplatin delivery to ovarian cancer cell lines A2780S and A2780CP.  相似文献   

14.
We report on the feasible fabrication of microfluidic devices for ferroelectric polymers'' synthesis in a rapid and stable fashion. Utilizing micro-mixing and flow-focusing in microchannels, poly(vinylidene fluoride-trifluoroethylene) and copper phthalocyanine are uniformly dispersed in one hydrogel particle, which are then demonstrated to immediate and complete on-chip steady polymerization by moderate ultraviolet treatment. The advantage of our droplet-based microfluidic devices is generating versatile particles from simple spheres to disks or rods, and the lengths of particles can be precisely tuned from 30 to 400 μm through adjusting the flow rates of both disperse and oil phases. In addition, this mixed technique allows for the continuous production of dielectric microparticles with controlled dielectric properties between 10 and 160. Such a microfluidic device offers a flexible platform for multiferroic applications.  相似文献   

15.
This paper proposes a quantitative analysis of social distance between Open Science and Proprietary Technology. A few general properties of social networks within both realms are discussed, as they emerge from the new economics of science and recent applied work on “small worlds”. A new data-set on patent inventors is explored, in order to show that social networks within Proprietary Technology are much more fragmented than Open Science ones, except for science-based technologies. Two propositions are then put forward on the “open” behaviour expected from academic inventors, namely university scientists getting involved in Proprietary Technology networks by signing patents. Both propositions are confirmed by data, which show academic inventors to be more central and better connected than non-academic ones. The database and methodology produced for this paper are suggested to be relevant for the more general debate on the role of geographical and cognitive distance in university-industry technology transfer.  相似文献   

16.
In this study, an adaptive fractional order sliding mode controller with a neural estimator is proposed for a class of systems with nonlinear disturbances. Compared with traditional sliding mode controller, the new proposed fractional order sliding mode controller contains a fractional order term in the sliding surface. The fractional order sliding surface is used in adaptive laws which are derived in the framework of Lyapunov stability theory. The bound of the disturbances is estimated by a radial basis function neural network to relax the requirement of disturbance bound. To investigate the effectiveness of the proposed adaptive neural fractional order sliding mode controller, the methodology is applied to a Z-axis Micro-Electro-Mechanical System (MEMS) gyroscope to control the vibrating dynamics of the proof mass. Simulation results demonstrate that the proposed control system can improve tracking performance as well as parameter identification performance.  相似文献   

17.
This paper evaluates the typically applied rules for awarding R&D subsidies. We identify two sources of inefficiency: the selection based on a ranking of individual projects, rather than complete allocations, and the failure to induce competition among applicants in order to extract and use information about the necessary funding. In order to correct these inefficiencies we propose mechanisms that include some form of an auction in which applicants bid for subsidies. Our proposals are tested in a simulation and in controlled lab experiments. The results suggest that adopting our proposals may considerably improve the allocation.  相似文献   

18.
Chaotic waveforms are natural information carriers since a correspondence can be established between the symbolic dynamics of a chaotic oscillator and the symbols of a message. Message symbols can be efficiently encoded in a chaotic waveform by applying vanishingly small perturbations to an oscillator to guide its symbolic dynamics to follow a desired course. Recently, two chaotic hybrid dynamical systems were shown to have matched filters enabling robust reception of chaotic communication waveforms in the presence of noise. The first of these, the exact shift oscillator, produces waveforms with desirable properties similar to antipodal signaling, but a physical implementation may be difficult to control using small perturbations. The second oscillator, the exact folded-band oscillator, produces less optimal waveforms but is more easily controlled. Here we introduce a method for generating waveforms of the exact shift oscillator by summing waveforms from a bank of easily controlled exact folded-band oscillators. We show that any solution of the exact shift oscillator can be so constructed using only three folded-band oscillators. Thus, this scheme allows us to realize the advantages of both chaotic systems while overcoming their individual disadvantages, thereby enabling practical chaos communications.  相似文献   

19.
The non-Newtonian properties of blood are of great importance since they are closely related with incident cardiovascular diseases. A good understanding of the hemodynamics through the main vessels of the human circulatory system is thus fundamental in the detection and especially in the treatment of these diseases. Very often such studies take place in vitro for convenience and better flow control and these generally require blood analogue solutions that not only adequately mimic the viscoelastic properties of blood but also minimize undesirable optical distortions arising from vessel curvature that could interfere in flow visualizations or particle image velocimetry measurements. In this work, we present the viscoelastic moduli of whole human blood obtained by means of passive microrheology experiments. These results and existing shear and extensional rheological data for whole human blood in the literature enabled us to develop solutions with rheological behavior analogous to real whole blood and with a refractive index suited for PDMS (polydymethylsiloxane) micro- and milli-channels. In addition, these blood analogues can be modified in order to obtain a larger range of refractive indices from 1.38 to 1.43 to match the refractive index of several materials other than PDMS.  相似文献   

20.
This paper presents a proposition of a sliding mode controller for a rigid manipulator expressed in terms of the generalized velocity components (GVC) vector. Introduction of GVC (Trans. ASME J. Appl. Mech. 62 (1995) 216) together with generalized positions leads to two first-order decoupled equations of motion instead of a single second-order equation. It is shown that the new controller, stable in the sense of Lyapunov, has different properties and can, according to Slotine and Li (Int. J. Robotics Res. 6 (1987) 49), give better performance than the classical sliding mode controller. Both control algorithms were tested on a 3 d.o.f., 3-D Yasukawa-like robot.  相似文献   

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