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甲流病原体能进入人体的主要门户就是鼻孔、口和咽喉。尽管种种预防措施已经实施,可是面对甲型流感的全球性疫情,想要完全避免接触甲流病毒几乎是不可能的。北京地坛医院感染性疾病诊治中心主任李兴旺提示,与其想尽办法不接触甲流病毒,不如生 相似文献
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2009年,甲型H1N1流感在北京爆发后,北京市政府一边防控疫情蔓延,一边聚集一流的科技资源和人才,研究利用传统中医药防治甲流的方法.结果只用了短短8个多月的时间,就成功研制了能有效预防和治疗甲流的中药制剂"金花清感颗粒". 相似文献
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问：媒体宣传说甲流的易感人群是青壮年,但接种疫苗为什么把老人当做重点？是不是第二波甲流的易感人群有所变化？
答：甲型H1Nl流感是由新变异产生的病毒导致的,全人群普遍易感。不过,从现有数据来看,老年人的发病率较低,但病死率较高; 相似文献
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<正>病毒凶猛,以甲流为甚!现在,全世界都在防控甲流(H1N1),小璐和小诺也不例外。只是,小璐闹不明白,为什么现在病毒越来越频繁地骚扰我们的生活。除了2009年大面积爆发的甲型N1H1流感外,前几年的非典(SARS)、禽流感等,都给我们的生活制造了大麻烦,很多人在病毒的肆虐中失去了生命。病毒究竟是什么呢?本期特别关注,我们就来看看在"病毒"身上究竟发生着什么…… 相似文献
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Chatterjee S Dhar S Sengupta B Ghosh A De M Roy S Chakrabarti S 《Indian journal of clinical biochemistry : IJCB》2010,25(3):260-272
Polycyclic aromatic hydrocarbons of tobacco require activation by phase I enzymes, such as cytochrome-P4501A1 (CYP1A1) to
become an ultimate carcinogen, which are subjected to detoxification by phase II enzymes, especially glutathione S-transferases (GSTs). A study was designed to find whether genetic predisposition are risk modifiers of oral pathologies.
The study included 102 cases with Oral Cancers (OCs), 68 cases with nonmalignant pathologies, 100 cases as control group.
GSTM1 null genotype was associated with increased risk of OCs but not with benign pathologies. Deleted GSTT1 was associated
with all pathologies. Both m1m2 and m2m2 polymorphisms of CYP1A1 were associated with oral pathologies. 相似文献
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BackgroundQuizalofop-p-ethyl (QPE), a unitary R configuration aromatic oxyphenoxypropionic acid ester (AOPP) herbicide, was widely used and had led to detrimental environmental effects. For finding the QPE-degrading bacteria and promoting the biodegradation of QPE, a series of studies were carried out.ResultsA QPE-degrading bacterial strain YC-XJ1 was isolated from desert soil and identified as Methylobacterium populi, which could degrade QPE with methanol by cometabolism. Ninety-seven percent of QPE (50 mg/L) could be degraded within 72 h under optimum biodegradation condition of 35°C and pH 8.0. The maximum degradation rate of QPE was 1.4 mg/L/h, and the strain YC-XJ1 exhibited some certain salinity tolerance. Two novel metabolites, 2-hydroxy-6-chloroquinoxaline and quinoxaline, were found by high-performance liquid chromatography/mass spectroscopy analysis. The metabolic pathway of QPE was predicted. The catalytic efficiency of strain YC-XJ1 toward different AOPPs herbicides in descending order was as follows: haloxyfop-p-methyl ≈ diclofop-methyl ≈ fluazifop-p-butyl > clodinafop-propargyl > cyhalofop-butyl > quizalofop-p-ethyl > fenoxaprop-p-ethyl > propaquizafop > quizalofop-p-tefuryl. The genome of strain YC-XJ1 was sequenced using a combination of PacBio RS II and Illumina platforms. According to the annotation result, one α/β hydrolase gene was selected and named qpeh1, for which QPE-degrading function has obtained validation. Based on the phylogenetic analysis and multiple sequence alignment with other QPE-degrading esterases reported previously, the QPEH1 was clustered with esterase family V.ConclusionM. populi YC-XJ1 could degrade QPE with a novel pathway, and the qpeh1 gene was identified as one of QPE-degrading esterase gene.How to cite: Li X, Wang J, Wu W, et al. Co-metabolic biodegradation of quizalofop-p-ethyl by Methylobacterium populi YC-XJ1 and identification of QPEH1 esterase. Electron J Biotechnol 2020;46. https://doi.org/10.1016/j.ejbt.2020.05.003. 相似文献
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Sadegh Fattahi Mohammad Karimi Alivije Farhang Babamahmoodi Masomeh Bayani Mahmoud Sadeghi Haddad Zavareh Mohsen Asouri Maryam Lotfi Galia Amirbozorgi Haleh Akhavan-Niaki 《Indian journal of clinical biochemistry : IJCB》2018,33(4):467-472
Hepatitis B virus (HBV) infection is a worldwide health concern which is associated with significant morbidity and mortality. Both viral and host factors have a significant effect on infection, replication and pathogenesis of HBV. The aim of this study was to investigate the effect of CYP2E1 and CYP1A1 genetic variants on susceptibility to HBV. 143 individuals including 54 chronic HBV patients and 89 healthy controls were enrolled in the genotyping procedure. rs2031920 and rs3813867 at CYP2E1 as well as rs4646421 and rs2198843 at CYP1A1 loci were studied in all subjects using PCR–RFLP (restriction fragment length polymorphism) analysis. Both variants at CYP2E1 locus were monomorphic in all studied subjects. Genotype frequency of rs4646421 was significantly different between chronic HBV patients and healthy blood donors (P = 0.04, OR 4.31; 95% CI 1.04–17.7). Furthermore, individuals carrying at least one C allele (CC or CT genotypes) for rs4646421 seemed to have a decrease risk of hepatitis in comparison with TT genotype (P = 0.039). Our results showed a relationship between rs4646421 TT genotype (rare genotype) and the risk for developing chronic HBV infection (four times higher). Further studies are needed to examine the role of CYP1A1 polymorphism in susceptibility to chronic HBV infection. 相似文献
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