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11.
The paper describes a new technique to synthesize a finite impulse response of linear time-variant (LTV) digital filter. First, a finite impulse response is decomposed into a sum of products of two orthogonal sequences. The direct implementation of the decomposed impulse response leads to the parallel connection of linear time-invariant (LTI) digital filters, followed by time-varying multipliers. A simple filter structure is obtained by properly modifying the sequences to realize the parallel form structure as a cascade connection of first- or second-order recursive LTI filters. The structure is easy to implement on a computer and saves computation time. Numerical examples illustrating the technique are included. 相似文献
12.
R. Katyal S V Rana S. Ojha V. Singh R. P. Aggarwal 《Indian journal of clinical biochemistry : IJCB》2005,20(1):118-122
The aim of the study was to evaluate the influence of rotavirus (RV) and soyabean trypsin inhibitor (TI) on lipid composition
and uptake of glucose and glycine in rotavirus (RV) infected malnourished (PEM) infant mice. Malnutrition was achieved in
animals by doubling the litter size. Cholesterol (Ch) and phospholipd (PL) contents, uptake levels of glucose and glycine
were determined in jejunum and ileum portion of small intestine. Increase in Ch/PL ratios was observed in PEM+RV group. The
levels became comparable in PEM+RV+TI as compared to PEM. Uptake levels of glucose and glycine increased in PEM animals. With
rotavirus (PEM+RV+TI group), the levels decreased which became comparable to PEM. Changes in uptake and lipid composition
with rotavirus and trypsin inhibitor may be responsible for altering membrane fluidity and organization during rotavirus diarrhea.
The results establish the importance of trypsin inhibitor during oral infection with rotavirus. 相似文献
13.
Naveen Chitkara R. C. Dadoo Sadhna Bansal Kiran Chugh S. K. Aggarwal Harbans Lal 《Indian journal of clinical biochemistry : IJCB》1996,11(2):162-164
Plasma vitamin E levels were estimated in 75 patients each of carcinoma breast and benign breast diseases. Mean plasma vitamin E concentration was found to be significantly reduced in malignancy compared to the controls as well as the non malignant conditions. The decrease in plasma vitamin E in cancer patients was directly related with the TNM stage of cancer. The levels, however, did not vary significantly with respect to histopathology or after 8 days of surgery. 相似文献
14.
Antioxidant vitamins and chemoprevention 总被引：1，自引：0，他引：1
Harbans Lal Rajesh Pandey S. K. Aggarwal 《Indian journal of clinical biochemistry : IJCB》1999,14(1):1-11
Free radicals play an important role in human carcinogenesis and the mechanism of their counteraction by antioxidant vitamins
has been reviewed. It seems more likely that these vitamins work in concert rather than acting singly. Currently available
data are compatible with the notion that these vitamins act as chemopreventives against some important cancers, e.g. carotenoids
for lung cancer, ascorbic acid for salivary gland cancer, tocopherols for head and neck cancers etc. Thus, a greater consumption
of fruits and vegetables should be encouraged as they are the natural sources of these chemopreventive, antioxidants along
with other protective factors packaged by nature. However, much work still remains to be done to establish the role of antioxidant
vitamins in carcinogenesis. 相似文献
15.
Objective: A series of 4-aryl substituted semicarbazones of levulinic acid (4-oxo pentanoic acid) was designed and synthesized to meet the structural requirements essential for anticonvulsant activity. Methods: All the compounds were evaluated for anticonvulsant activity. Anticonvulsant activity was determined after intraperitoneal (i.p.) administration to mice by maximal electroshock (MES) and subcutaneous metrazol (ScMet) induced seizure methods and minimal motor impairment was determined by rotorod test. Results: A majority of the compounds exhibited significant anticonvulsant activity after intraperitoneal administration. In the present study 4-(4'-fluoro phenyl) levulinic acid semicarbazone emerged as the most active molecule, showing broad spectrum of activity with low neurotoxicity. Unsubstituted levulinic acid semicarbazone was found to be inactive in all the screens. Conclusion: The results obtained validate the hypothesis that presence of an aryl group near the semicarbazone moiety is essential for anticonvulsant activity. The results also indicate that the hydrophilic-hydrophobic site can accommodate hydrophilic groups. 相似文献
16.
Goverdhan Lal S. P. S. Yadav S. K. Aggarwal Sadhna Bansal Kiran Chugh Harbans Lal 《Indian journal of clinical biochemistry : IJCB》1996,11(1):46-48
Plasma vitamin E and malondialdehyde (MDA) concentrations were estimated in a group of 25 patients (17 males and 8 females) with head and neck cancer and the results were compared with a group of normal healthy controls. Plasma vitamin E levels were found to be significantly reduced while MDA levels were increased in patients than the controls. The fall in vitamin E was nearly same in all the patients studied irrespective of the site, TNM stage, histopathology and character of lesion. The levels did not vary immediately after radiotherapy but were significantly increased 3 months after the radiotherapy. These preliminary data suggest that the cancer patients have suboptimal vitamin E status which may be a contributory factor for increased lipid peroxidation in such cases. 相似文献
17.
Joya Ghosh T. K. Mishra Y. N. Rao S. K. Aggarwal 《Indian journal of clinical biochemistry : IJCB》2006,21(1):181-184
Coronary artery disease is a major cause of morbidity and has various risk factors. Lipid profile i.e. low HDL-cholesterol,
high LDL cholesterol, high total cholesterol, high triglycerides playing important role in its causation. Recently interest
has been shown in the oxidized fraction of LDL as one of the risk factors. In the present study 60 age and sex matched normal
healthy individuals were taken as controls and 60 patients of CAD were taken. Cholesterol was measured by enzymatic method,
HDL cholesterol by phosphotungstate precipitation method. Serum levels of LDL fraction of cholesterol was measured by a new
and simpler method of precipitation. Result was expressed as mol/L of diene conjugates. It was observed that LDL cholesterol,
VLDL cholesterol, total cholesterol, total cholesterol: HDL cholesterol, LDL cholesterol: HDL cholesterol were significantly
raised and HDL cholesterol was significantly low in patients. (p<0.001). Though HDL cholesterol was significantly raised in
females as compared to males in both the groups (p<0.001). Serum level of total cholesterol, oxidized LDL:HDL cholesterol
were also raised significantly (p<0.05). The level of oxidized LDL showed an increasing trend in patients. 相似文献
18.
Harbans Lai Rajesh Pandey S. K. Aggarwal 《Indian journal of clinical biochemistry : IJCB》2000,15(1):158-168
The past two decades have witnessed new facets in vitamin D metabolism. Free vitamin D3 till now considered to be limited to animal sources, has been shown to occur in plants. Further, the extrarenal synthesis of active vitamin D3 or calcitriol has been documented in physiological as well as in certain pathological conditions. At the cellular level, calcitriol acts through a dual mechanism. The genomic pathway involves the vitamin D receptor (VDR) which is of ubiquitous distribution and linked with various diseases. Besides, a nongenomic VDR—independent pathway also exists. The biological effects of calcitriol can no longer be dismissed by merely referring to calcium/bone homeostasis. It enhances the perinatal growth and suppresses the abnormal growth, as well. The effects on the endocrine, immune, cardiovascular, reproductive and nervous systems have also been characterized. It is compelling to believe that calcitriol and/or its analogues will find extensive applications at least in the treatment of osteoporosis, perinatal growth retardation, neoplasia, psoriasis, insulin resistance and transplantation. 相似文献
19.
This study, which was conducted within a college of further education in London, explored students' attitudes towards people with mental ill health, and examined whether these impact on the learning and well‐being of students with mental illness. The study was carried out in response to complaints about negativity about mental illness within the college. A combination of quantitative and qualitative methods were employed, which consisted of semantic differential surveys and semi‐structured interviews. Analysis of the results of the latter revealed the presence of stereotypes and prejudice, which had the potential to impact negatively upon learners with mental disorders. The article makes a number of recommendations for future teaching practice, which includes a need to raise awareness of mental health issues, and challenge stereotypes and negative attitudes relating to mental illness, within the classroom. 相似文献
20.
Assessment is becoming important from many different perspectives. Universities are planning, developing, and testing various assessment models to satisfy stakeholders. Many accrediting agencies are also requiring assessment plans and their implementation from universities for reaccreditation. This article describes how assessment was used to continuously improve a database course in a Web MBA program, and combines Deming's Plan‐Do‐Check‐Act (PDCA) cycle with Bloom's taxonomy to develop rubrics for problem solving learning objectives in an online course. Results from direct and indirect measurements are used to improve the course. Specifically, two semester results are compared for course assessment. Results show some improvement; however, the course requires continuous improvement to meet benchmarks. The model presented here is generic in nature and should be useful for all educators who plan to initiate or continue the assessment and continuous improvement process. Instead of reinventing the wheel, educators can learn from our experiences and use the results as a starting point for their own assessment programs. 相似文献